Guest guest Posted May 22, 2004 Report Share Posted May 22, 2004 I agree Yash ... I found this in March while looking at Samters for a friend .. I posted it on the samters site ... You are certainly on to something .. All the Best " Read this ... http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Apoptosis.htm l From that is is clear that defects in the apoptotic machinery are associated with autoimmune diseases .... Here is a good example .... " The hallmark of AIDS (acquired immunodeficiency syndrome) is the decline in the number of the patient's CD4+ T cells (normally about 1000 per microliter (µl) of blood). CD4+ T cells are responsible, directly or indirectly (as helper cells), for all immune responses. When their number declines below about 200 per µl, the patient is no longer able to mount effective immune responses and begins to suffer a series of dangerous infections. What causes the disappearance of CD4+ T cells? HIV (human immunodeficiency virus) invades CD4+ T cells, and one might assume that it this infection by HIV that causes the great dying-off of these cells. However, that appears not to the main culprit. Fewer than 1 in 100,000 CD4+ T cells in the blood of AIDS patients are actually infected with the virus. So what kills so many uninfected CD4+ cells? The answer is clear: apoptosis. " LDN prevents HIV developing into full blown AIDS according to Dr Bihari's studies to date .. I agree an outrageous claim that is in dire need of a clinical trial .... but based on the fact that the drug is cheap and can do no harm I would try it. If Dr Bihari is right then LDN must rectify the apoptotic machinery ... further indicating it would be an effective option for nasal polyp prevention. " > I think one mechanism by which LDN acts is by decreasing apoptosis > (or programmed cell death)of neuronal cells. Here's how. > > First: LDN prevents apoptosis by preventing increase of fas ligand. > Fas ligand is a crucial component in apoptosis. > > J Immunol. 2002 Apr 15;168(8):4025-33. > Role of p38 mitogen-activated protein kinase phosphorylation and Fas- > Fas ligand interaction in morphine-induced macrophage apoptosis. > > Second: Inhibition of fas ligand promotes oligodendrocyte and > neuronal regeneration. > > D. Demjen et al., " Neutralization of CD95 ligand promotes > regeneration and functional recovery after spinal cord injury, " Nat > Med, 10:389-95, April 2004. > > Third: Apoptosis is the main abnormality in MS. > > Ann Neurol. 2004 Apr;55(4):458-68. > Relapsing and remitting multiple sclerosis: pathology of the newly > forming lesion. > > On top of this, LDN increases endorphins, which promote a sense of > well being. > > When I have time, I will try to get this hypothesis published, but > you heard it here first!. > > Yash Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2004 Report Share Posted May 22, 2004 YASH- THE FOCUS OF MY CLINIC IDEA IS GOING TO BE GETTING TRIALS FOR NALTREXONE. I'M GOING TO PRESENT IT TO UMASS AND SAINTS MEMORIAL HOSPITAL. WHAT DO YOU THINK? BESTAUNT Quote Link to comment Share on other sites More sharing options...
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