Found this on 4-AP - Anyone using it ?

[Guest guest]

Hi guys, I found this on website: www.newmobility.com

Has anyone here used this 4-AP? Apart from Spinal Cord Injuries, I

wonder if it can be used for MS and other nervous system damaging

diseases?

Friday (I seem to recall maybe reading something about it on here,

but not entirely sure

Dear Uncle Spine: What is the latest on 4-AP, the next-big-thing drug

we've been hearing about forever? Norvell

4-aminopyridine, a.k.a. 4-AP, is a nerve signal booster. It works by

jacking up conduction in nerve fibers that are whole but don't work

well because of faulty myelin insulation. About one in three SCI

people will improve with 4-AP, but it's not possible to predict who

will benefit or what effect the drug will have on those who do. Some

get movement, some get erections, some get pain relief. Sometimes the

results are quite dramatic.

Acorda Therapeutics, a New York company, has completed a Phase II

clinical trial testing a time-release dosage of 4-AP on people with

spinal cord injuries. Results are not available yet but the word on

the gimp grapevine is that the doses were too light and therefore the

drama was light. Still, the company hopes to get on with a much

larger Phase III trial this year.

A recent report from the Long Beach VA fuels enthusiasm for 4-AP.

Physician Jack Segal studied 21 patients, all at least two years post-

injury. On average, they regained at least 1 to 1.5 neurological

levels of function after three months of getting the drug. " There

were significant changes in patients' ability to carry out activities

of daily living, " he says. The drug also improved pulmonary function

by 30 percent to 40 percent, a big deal for quads and vent-users.

Well, you say, I want my 4-AP. Of course you do. Ask your doctor to

prescribe it (it's legal, but totally " off-label " since the drug's

not approved for any use other than bird repellent). There are many

pharmacies in the U.S. that will formulate 4-AP for you. It's usually

less than $50 a month and you will have to play with the dose. But

don't play too much. You OD on this stuff and your whole system can

power up into a seizure

[Guest guest]

The two times I tried 4-AP, I ended up with SEVERE vertigo. Nobody

could determine why (dosage, ingredients) but it was so bad I won't

try it again.

spms

[Guest guest]

Thankyou .

Now I know it's been tried on MS Patients as well. Personally, I'm

not willing to rock the LDN boat. I'm happy as is.

Your post helped alot, Take care.

Friday

> The two times I tried 4-AP, I ended up with SEVERE vertigo. Nobody

> could determine why (dosage, ingredients) but it was so bad I won't

> try it again.

>

>

> spms