inosine

[Guest guest]

Hi, ,

>INOSINE CAPSULES

>Inosine belongs to a chemical family known as purine nucleotides. It

>penetrates cell walls of both cardiac and skeletal muscle and once inside

>promotes the manufacture of ATP which is the chemical in the body that

>allows muscles to contract.

Inosine is the next step down the pathway of adenosine degradation.

Adenosine and inosine can interconvert inside the cell. In most people it,

or the next step hypoxanthine, can be absorbed into cells and recycled into

adenosine, or the other purine guanosine.

It seems that inosine should be a way of getting more purines without the

potential drug effects of adenosine - adenosine IV is used to restore normal

heart rhythmsby slowing nerve conduction at certain critical points on the

heart.

I don't know whether taking inosine would be any better than taking

additional DNA.

One important point is that anyone who has gout, or IMO even has gout in the

family, should avoid this as it will raise the anount of uric acid in the

bloodstream.

Jerry

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[Guest guest]

Hello Gretchen,

I remember that I saw a phase one study of Inosine with ALS. The reason for

that, all the marketing of Inosine on the internet mentions that it helps

people with ALS with improvement of 10-15 per cent. I was able to dig up an

outline of the study but the result was that 50% saw improvement of 10% -

15%. I look for some thing like this because it is readily available. I do

not mind an improvement of 10% - 15% as long as it is safe. What I mean by

safe is, the long term effects are know not cause any problems or make my

condition worse.

Unfortunately the FDA does not regulate Dietary Supplement as it does

prescription drugs. The FDA recently has moved to ban any harmful

nutritional supplement but that is not enough to know the purity of the

supplement that you are taking, or whether the vitamins that you are taking

are exactly what it says on the label?

Thanks for the info that was helpful:-)

Nidal

-----Original Message-----

From: Gretchen Glick [mailto:liliwigg@...]

Sent: Thursday, January 01, 2004 10:22 AM

ers at groups

Subject: Inosine

Nidal,

Far as I can tell, no academic/medicalstudies out on Inosine for CMT or

PN. Looks like even for HIV-1 it is still in the rat-earthworm-pig

experimental stages. China seems to be a popular place for making

Inosine.

This may be of interest - after the references, there is a section on

" Frequently Asked Questions " .

INOSINE

Metabolically, inosine is an intermediate in a number of purine

nucleotide pathways that affect the ability of the muscle to work

efficiently. Some fitness experts claim that inosine can have a positive

effect on overall physical strength and energy during

exercise.

Energy is what the muscles of athletes involved in aerobic,

high-intensity exercise require. This short-duration energy requirement

is produced by the breakdown of glycogen, which produces ATP (adenosine

triphosphate), the currency of bodily energy. This is also called the

aerobic pathway of energy production. After two to three minutes of

intense exercise, aerobic pathway becomes the major source of energy

production as the body begins to use oxygen to burn nutrients for

energy. In aerobic metabolism, the body uses glucose, fatty acids and

amino acids to produce energy that the muscles rely upon.

Ultimate Nutrition's Premium Inosine supports the body in production of

short bursts of energy during intense, aerobic exercise. Importantly,

inosine increases the body's ability to handle rigorous exercise without

inducing fatigue. What is Inosine? Inosine, also known as hypoxanthine

riboside, belongs to a class of naturally occurring compounds called

purine nucleotides, which are the building blocks of DNA and RNA.

Adenosine in ATP is also a purine nucleotide.

Inosine penetrates the cell walls of both the heart and skeletal muscle

and, once

inside the cell, promote the production of ATP, which helps the muscle

to contract. In addition, inosine also facilitates the transport of

oxygen from the circulating blood to various tissues in the body

including the muscle. Combination of these two important properties

makes it a valuable dietary supplement for athletes whose goal is to

exercise for longer periods of time without experiencing muscle fatigue.

Inosine is also known to activate various enzyme systems in the body,

and it plays a crucial role in protein synthesis. Availability of

abundant amounts of the protein in the muscle is necessary in order for

the muscle to repair and grow, remodeling the tissue that the athletes

need for performance. Furthermore, in aerobic energy production, protein

is first broken down into amino acids before it can be used as a fuel to

produce energy. Therefore, nutritional supplementation with inosine for

enhanced performance during high-intensity aerobic exercise can hardly

be overemphasized.

Ultimate Nutrition's Premium Insoine Capsules guarantees the highest

potency and maximal effectiveness in fulfilling your energy needs. Being

of the highest quality, Premium Inosine not only provides a ready source

of energy production but also supports faster muscle recovery and,

simultaneously, helps the body to tone and remodel the muscle for

enhanced performance.

SELECTED REFERENCES

1.Starling et al., " Effect of Inosine Supplementation on Aerobic and

Anaerobic Cycling Performance, " Med. Sci. Sports Exer.: 28, 1193, 1996

2.Rosenbloom et al., " Contemporary Ergogenic Aids Used by Strength/Power

Athletes, " J. Am. Diet Assoc.: 92, 1264, 1992

3.DiPrampero, P., " Energetics of Muscular Exercise, " Biochem.

Pharmacol.: 89, 143, 1981

4.s et al., " Sprint Training Effects on Muscle Myoglobin, Enzymes,

Fiber Types and Blood Lactate, " Med. Sci. Sports Exer.: 19, 369, 1987

5.sen, A. & Quistorff, B., " Inosine/Pyruvate/Phosphate Medium but

not

Adenosine/Pyruvate/Phosphate Medium Introduces Millimolar Amounts of

5-Phosphoribosyl 1-Pyrophosphate in Human Erythrocytes: A 31P-NMR

Study, " Biochem. J.: 266, 441, 1990

6.Kovacevic et al., " Interaction of Metabolism of Aspartate and Inosine

and Energy State of Human Cells, " Biochem. J.: 247, 47, 1987

7.Brouns, F., Nutritional Needs of the Athlete, Chichester, U. K.:

Wiley

FREQUENTLY ASKED QUESTIONS

1.In What Natural Sources in Inosine Found? edible organ meats.

2.Does Inosine Have Any Health Benefits Beyond Athletic Sports? The

major role of inosine in the cell is to produce energy and to help

transport oxygen to various tissues. Even though inosine is presently

used solely to provide bursts of energy in aerobic, active research is

being carried out to discover any other potential applications of this

invaluable nutritional supplement.

3.If Inosine and Adenosine Are Similar, Why Not Use Adenosine? While

insoine and adenosine are chemically similar and belong to the same

family of compounds, research has shown that nutritional supplementation

with inosine, and not adenosine, high-intensity athletes derive the

maximum benefit (see reference 5 above).

4.Could There Be Inosine Deficiency? Insoine is not an essential

nutrient. That is, it is not absolutely required for growth and

development. Consequently, inosine deficiency per se does not present

itself. Its long-term deficiency, however, could clinically be

discerned by several different criteria, such as lack of stamina and

inability

to maintain any activity that requires physical exertion, etc.

5.What is the Recommended daily Dosage of Inosine? Athletes tend to take

rather large dosages of inosine, which can vary between 2000 milligrams

to 5000 milligrams. To derive maximal benefits, dosages should be

tailored to individual needs and tolerance levels. The help of a

physical trainer and/or healthcare professional may also be necessary to

determine optimal inosine dosage.

6.What Are the Side Effects? No side effects associated with the

ingestion of inosine have been reported to-date.

This product is no longer available.

http://www.cmtworld.org

http://www.neurologychannel.com/charcot/

[Guest guest]

I took inosine until 1year now 5gr per day at first my acid uric level was 133mol very low now

it`s at 233mol not very high but it`s better .I`am stable since 10 months. MSN Search, le moteur de recherche qui pense comme vous ! Cliquez-ici