Re: spms III human trials this fall

[Guest guest]

Tom,

would you know if minocycline is the same product that you talk

about here? The reason I ask is because my neuro Dr Jack Antel in

MS research in Montreal, quebec spoke to me about a drug that seems

very promising co9ming out of Alberta. Also I know a person from

France who's doctor gives him this drug. He said it comes from

Alberta and is experimental. So I'm wondering if there is a

connection among all this info. thank you.

>

> And right here in Edmonton, too. Dr. Warren is my neuro, and I

have ppms. I sure hope it helps that too.......

>

> MBP8298, Product ... MBP). MBP8298 has been developed for the

treatment of

> multiple sclerosis (MS), and is based on over 26 years of

research. ...

> www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages

> I didn't now if any of you knew of this or not.

>

> Tom from EDMONTON

>

[Guest guest]

Minocyline is an antibiotic that has been helpful for some people. Here is a website with some info:

http://www.thisisms.com/article112.html

----- Original Message -----

From: Johanne F

low dose naltrexone

Sent: Tuesday, July 13, 2004 6:34 AM

Subject: [low dose naltrexone] Re: spms III human trials this fall

Tom,would you know if minocycline is the same product that you talk about here? The reason I ask is because my neuro Dr Jack Antel in MS research in Montreal, quebec spoke to me about a drug that seems very promising co9ming out of Alberta. Also I know a person from France who's doctor gives him this drug. He said it comes from Alberta and is experimental. So I'm wondering if there is a connection among all this info. thank you.> > And right here in Edmonton, too. Dr. Warren is my neuro, and I have ppms. I sure hope it helps that too.......> > MBP8298, Product ... MBP). MBP8298 has been developed for the treatment of> multiple sclerosis (MS), and is based on over 26 years of research. ... > www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages > I didn't now if any of you knew of this or not.> > Tom from EDMONTON>

[Guest guest]

So if minocycline the antibiotic helps with M.S. Then could this be a different disease other than M.S,like Lymes disease? Or could someone have both,and the Dr.s only see the M.S. try to treat the M.S. have not so good results and fail to see the underlying Lymes disease?

Just a thought.

Reg

-------Original Message-------

From: low dose naltrexone

Date: 07/13/04 07:54:03

low dose naltrexone

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

Minocyline is an antibiotic that has been helpful for some people. Here is a website with some info:

http://www.thisisms.com/article112.html

----- Original Message -----

From: Johanne F

low dose naltrexone

Sent: Tuesday, July 13, 2004 6:34 AM

Subject: [low dose naltrexone] Re: spms III human trials this fall

Tom,would you know if minocycline is the same product that you talk about here? The reason I ask is because my neuro Dr Jack Antel in MS research in Montreal, quebec spoke to me about a drug that seems very promising co9ming out of Alberta. Also I know a person from France who's doctor gives him this drug. He said it comes from Alberta and is experimental. So I'm wondering if there is a connection among all this info. thank you.> > And right here in Edmonton, too. Dr. Warren is my neuro, and I have ppms. I sure hope it helps that too.......> > MBP8298, Product ... MBP). MBP8298 has been developed for the treatment of> multiple sclerosis (MS), and is based on over 26 years of research. ... > www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages > I didn't now if any of you knew of this or not.> > Tom from EDMONTON>

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[Guest guest]

In reading it thru I kinda read that MBP (for short) works only on limiting the attacks.

What do you gather from this?

Reg.

-------Original Message-------

From: low dose naltrexone

Date: 07/12/04 18:36:37

low dose naltrexone

Subject: [low dose naltrexone] spms III human trials this fall

And right here in Edmonton, too. Dr. Warren is my neuro, and I have ppms. I sure hope it helps that too.......

MBP8298, Product ... MBP). MBP8298 has been developed for the treatment ofmultiple sclerosis (MS), and is based on over 26 years of research. ... www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages

I didn't now if any of you knew of this or not.

Tom from EDMONTON

Bioms Medical - Homepage... What does MBP8298 stand for? "MBP" - Myelin Basic Protein "8298" - The natural sequenceof amino acids in the molecule top of page. Who developed MBP8298? ... www.biomsmedical.com/patientfaq.asp - 11k - Cached - Similar pages[ More results from www.biomsmedical.com ]

What is MBP8298?More MS news articles for March 2001. What is MBP8298? http://www.rycortech.com/frame.html.Rycor Technology website 20 March 2001. What is MBP8298? ... www.mult-sclerosis.org/news/Mar2001/MBP8298.html - 4k - Cached - Similar pages

This following letter is a bit out of date, but they are beginning to start tests this Fall, ie., of 2004. Of interest to ppms'rs.

Edmonton Researchers Test Treatment for Multiple Sclerosis

http://www.mssociety.ca/en/research/DMT010504.htm Medical Update Memo May 4, 2001 Summary Researchers Drs. Warren and Ingrid Catz, University of Alberta, have developed what may be a potential treatment for people who have progressive forms of multiple sclerosis, according to information issued by the company which will fund the clinical trial of the therapy. The researchers have developed a synthetic segment of myelin basic protein called MBP8298. Myelin basic protein is one of the major proteins that make up myelin, the protective insulating covering of the central nervous system. A large, controlled Phase III study should begin in 2002. The Multiple Sclerosis Society of Canada welcomes the launch of a Phase III study that should provide definitive information about the effectiveness of MBP8298. Details Dr. Warren, director of the MS Clinic in Edmonton, and Dr. Ingrid Catz, senior scientist at the University of Alberta, have developed a synthetic segment of myelin basic protein called MBP8298. According to information released by EPS Capital Corp. of Edmonton, the substance puts people with progressive MS in remission, as measured by a drop in antibody levels in spinal fluid. Drs. Warren and Catz report their research has found there are increased antibodies to myelin basic protein (MPB) in people with progressive forms of MS. They measure this increase by examining fluid drawn from the base of the spine in a standard procedure called a lumbar puncture or spinal tap. Before the wide-spread use of magnetic resonance imaging (MRI) scanning, examination of the spinal fluid to determine if there were increased levels of antibodies was used to confirm the clinical diagnosis of MS. The researchers have been involved in the development of MBP8298 for more than 20 years. The investigators have given the product to approximately 100 people over the past 10 years in both Phase I and Phase II clinical studies. They report that of 41 people with progressive MS, 61% went into remission as measured by antibody levels in spinal fluid. Phase II study results are not yet available. The investigators report there are no clinically relevant side effects in those who have been given MBP8298 to date. The product is given by intravenous infusions (into the vein) at intervals of several months. A large, multi-centre, double-blind placebo-controlled Phase III study is scheduled to begin in 2002 at a number of MS clinics across Canada. More information will be provided when it becomes available. The Multiple Sclerosis Society welcomes the information about MBP8298 and looks forward to the launch of a Phase III study that should provide more definite information about the potential therapy, commented Dr. J. McIlroy, national medical advisor. Stages of clinical studies Multiple sclerosis is an extremely unpredictable disease with sudden attacks and spontaneous recovery, especially during the early years of the disease. Because of this, it is very difficult to determine whether a person's recovery was because of a treatment they were on or whether it would have happened naturally. To overcome this dilemma, possible treatments for MS and other diseases are tested under carefully controlled conditions. Here are the standard methods: Controlled trial: A study that compares the outcome of a group of randomly assigned participants who receive the experimental treatment to a group of equally randomly assigned participants who receive a standard treatment or an inactive placebo. Controlled trials are usually double-blind, which means neither the participant nor the examining physician knows if the person is on active treatment or placebo - both are "blinded". Phase I trial: A short, uncontrolled trial of an experimental therapy which is given to a few people (who may or may not have the disease). The primary outcome is to test for the safety of the therapy. Phase II trial: A controlled trial in a small number of people who have the disease that tests for safety and starts to gather data on whether the therapy actually works. Phase III trial: A controlled trial that tests a therapy in a large number of people with the disease, often at many research sites for a number of months. It collects data on safety, the effectiveness of the therapy and side effects. These data are necessary for any submission to Health Canada for evaluation of a therapy for possible approval.

Disclaimer The Multiple Sclerosis Society of Canada is an independent, voluntary health agency and does not approve, endorse or recommend any specific product or therapy but provides information to assist individuals in making their own decisions.

File Format: PDF/Adobe Acrobat - View as HTML... today announced that the University of Alberta has received seventeen additionalpatents for the Company’s synthetic peptide therapeutic, MBP8298, for the ... www.investbioms.com/Pdfs/currentpress_march23_2004.pdf - Similar pages[ More results from www.investbioms.com ]

Canada NewsWire... We continue to make good progress preparing our Clinical Trial Application forapproval to commence a pivotal trial for MBP8298, our lead drug for the ... www.newswire.ca/en/releases/ archive/May2004/14/c3631.html - 22k - 11 Jul 2004 - Cached - Similar pages BioMS Medical Corporation. BioMS Medical is focused on two promising products MBP8298 for the treatment ofmultiple sclerosis and HYC750 for the treatment of cancer therapy related side ... www.biofinance.ca/includes/ community/profilePop.cfm?contactsID=237 - 6k - Cached - Similar pages Clinical Trial Results - Week of June 9, 2003... BioMS Medical reported positive results from a phase II trial investigatingMBP8298, a synthetic peptide for the treatment of multiple sclerosis. ... www.centerwatch.com/patient/nmtresults/nmt030609.html - 26k - Cached - Similar pages www.biospace.com/ccis/search.cfm?tradename=MBP8298Similar pages[ More results from www.biospace.com ] JUNE 2004 - MSFYi... FIRST NFL PLAYER SIGNED WITH KNOWN MS. * MBP8298: POTENTIAL HOPE FOR SPMS. *ONLINE CHAT WITH COUNTRY STAR CLAY WALKER! ... MBP8298: POTENTIAL HOPE FOR SPMS. ... alz-youngstown.tripod.com/msfyijun.htm - 73k - Cached - Similar pages

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[Guest guest]

Just asking how can an antibiotic help with M.S.? Isn't that like taking penicillin for a cold?

Reg.

-------Original Message-------

From: low dose naltrexone

Date: 07/13/04 11:53:39

low dose naltrexone

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

Or are we back to the theory that MS isn't a disease but a collection of diseases that cause similar symptoms?

----- Original Message -----

From: Reg Kreil

low dose naltrexone

Sent: Tuesday, July 13, 2004 7:25 AM

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

So if minocycline the antibiotic helps with M.S. Then could this be a different disease other than M.S,like Lymes disease? Or could someone have both,and the Dr.s only see the M.S. try to treat the M.S. have not so good results and fail to see the underlying Lymes disease?

Just a thought.

Reg

-------Original Message-------

From: low dose naltrexone

Date: 07/13/04 07:54:03

low dose naltrexone

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

Minocyline is an antibiotic that has been helpful for some people. Here is a website with some info:

http://www.thisisms.com/article112.html

----- Original Message -----

From: Johanne F

low dose naltrexone

Sent: Tuesday, July 13, 2004 6:34 AM

Subject: [low dose naltrexone] Re: spms III human trials this fall

Tom,would you know if minocycline is the same product that you talk about here? The reason I ask is because my neuro Dr Jack Antel in MS research in Montreal, quebec spoke to me about a drug that seems very promising co9ming out of Alberta. Also I know a person from France who's doctor gives him this drug. He said it comes from Alberta and is experimental. So I'm wondering if there is a connection among all this info. thank you.> > And right here in Edmonton, too. Dr. Warren is my neuro, and I have ppms. I sure hope it helps that too.......> > MBP8298, Product ... MBP). MBP8298 has been developed for the treatment of> multiple sclerosis (MS), and is based on over 26 years of research. ... > www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages > I didn't now if any of you knew of this or not.> > Tom from EDMONTON>

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[Guest guest]

Yes to the latter. Neuro Lyme can mimic MS and when it does, minocycline works.

Miriam

----- Original Message -----

From: Reg Kreil

low dose naltrexone

Sent: Tuesday, July 13, 2004 7:25 AM

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

So if minocycline the antibiotic helps with M.S. Then could this be a different disease other than M.S,like Lymes disease? Or could someone have both,and the Dr.s only see the M.S. try to treat the M.S. have not so good results and fail to see the underlying Lymes disease?

Just a thought.

Reg

-------Original Message-------

From: low dose naltrexone

Date: 07/13/04 07:54:03

low dose naltrexone

Subject: Re: [low dose naltrexone] Re: spms III human trials this fall

Minocyline is an antibiotic that has been helpful for some people. Here is a website with some info:

http://www.thisisms.com/article112.html

----- Original Message -----

From: Johanne F

low dose naltrexone

Sent: Tuesday, July 13, 2004 6:34 AM

Subject: [low dose naltrexone] Re: spms III human trials this fall

Tom,would you know if minocycline is the same product that you talk about here? The reason I ask is because my neuro Dr Jack Antel in MS research in Montreal, quebec spoke to me about a drug that seems very promising co9ming out of Alberta. Also I know a person from France who's doctor gives him this drug. He said it comes from Alberta and is experimental. So I'm wondering if there is a connection among all this info. thank you.> > And right here in Edmonton, too. Dr. Warren is my neuro, and I have ppms. I sure hope it helps that too.......> > MBP8298, Product ... MBP). MBP8298 has been developed for the treatment of> multiple sclerosis (MS), and is based on over 26 years of research. ... > www.biomsmedical.com/MBP8298info.asp - 8k - Cached - Similar pages > I didn't now if any of you knew of this or not.> > Tom from EDMONTON>

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