Re: question on naltrexone

[Guest guest]

> a quick question.

> u said u bought the 50 mg dose - how do u make a 3mg

> dosage out of it.

> thanx.

> A T

How I prepare my ReVia pills.

1-I cut the ReVia pill in half on the diving line

2-I finely crush the pill in a small metal cup with a teaspoon

3-I put the crushed 25mg of ReVia in a dark bottle that has

ml measurments on the side

4-I add 25ml of demineralised water, but you can used distilled

water or even juice if you don't like the taste.

5-I keep the mixture in the fridge

6-Every time I take a dose I give the bottle a good shake because

ReVia does not disolve in liquid

7-I use a syringe or a baby eye dropper for giving syrop. Both have

mesurments in mls.

With this method I keep the ReVia fresh and I can try different

dosages as needed.

[Guest guest]

there is a wealth of info on the ldn study/usages on the chelatingkids2 group

( group). i know most of you are devout nids followers, however, there

is a lot of info on that list. i recd about 200 posts daily! lot of stuff to

go thru but, you are in connection with a tremendous amt of info from a

variety of people/ideas. worth while to read sometimes. make your own

decisions.

from what i have read on the chelatingkids2 list of those who have/are trying

this, nothing but good responses/posts. again, each child is different and

what helps for one may not for another. vicki

[Guest guest]

Doris,

I've heard about this too and wondered the same thing. Did you ever

ask Dr. G?

--- In , steve and doris smith <sjsmith3@c...>

wrote:

> Has anyone had the fortune to ask Dr Goldberg about

> this one?

> Kathy-Cyn-Cheryl - any input?

> Does anyone know Dr Klimas' opinion?

> Are we looking at the new 'flavor' of the month?

> or just another hoax?

>

>

> doris

> - maryland

>

> ....................................................................

> Low-Dose Naltrexone as Immunomodulator

> JAQUELYN McCANDLESS, M.D.

>

> Certified by American Board of Psychiatry & Neurology

> 21800 lee St., #48, Woodland Hills, CA 91367

> Telephone (818) 716-0565 Fax (818) 337-7338

> www.starvingbrains.com JMcCandless@p...

>

>

>

>

>

> LOW-DOSE NALTREXONE: INFORMAL CLINICAL STUDY REPORT, 7-1-05

>

>

>

> What is naltrexone? Naltrexone is an FDA-approved drug called

Revia used as

> an opiate antagonist, and has been used to treat opiate drug

addiction. At

> full dose, usually 50-150mg a day, it blocks the response to opiate

drugs

> such as heroin or morphine. I as well as many other DAN! doctors

have tried

> Naltrexone as an opioid blocker hoping to offset the opioid effects

of the

> large peptides in wheat and milk that are thought to affect our

kids

> adversely. However, I never found it to be useful for that

purpose, and I

> haven't heard of many others who have. Some studies were actually

done on

> autistic children by researchers to try to study this, but results

were not

> encouraging. I occasionally hear of it being used for SIB, but I

do not

> know its effectiveness in that regard.

>

>

>

> However, it has been shown that opioids can operate as cytokines,

operating

> through opioid receptors on immune cells and producing

immunomodulatory

> effects. The quality of an individual's immune system can be

evaluated

> through the balance of cytokines (e.g. interleukins and

interferons) it is

> producing. Cytokines are the principal communication signalers of

the

> immune system. A popular classification method is referred to as

the

> Th1/Th2 balance; Th1 cells promote cell-mediated immunity while Th2

cells

> induce humoral immunity. While cellular immunity (Th1) directs

Natural

> Killer T-cells and macrophages to attack abnormal cells and

microorganisms

> at sites of infection inside the cells, humoral immunity (Th2)

results in

> the production of antibodies used to neutralize foreign invaders

and

> substances outside of the cells. The inability to respond

adequately with a

> Th1 response can result in chronic infection and cancer; an

overactive Th2

> response can contribute to allergies, various syndromes and play a

role in

> autoimmune disease, which probably all of our ASD children have to

some

> extent.

>

>

>

> A Manhattan, New York physician, Dr. Bernard Bihari, studying the

immune

> responses in a group of AIDs patients, discovered that a very low

dose of

> naltrexone in less than one-tenth the usual dosage boosts the

immune system

> and helps fight any disease that is characterized by inadequate

immune

> function. As an effective up-regulator of the immune system, he

termed this

> new therapy Low-Dose Naltrexone (LDN) and has described remarkable

responses

> in those with AIDs, cancer, and autoimmune diseases such as

Multiple

> Sclerosis (MS). LDN tends to normalize the immune system by

elevating the

> body's endorphin levels but also accomplishes its results with

virtually no

> side effects or toxicity. I first got the idea of trying this on

ASD

> children from hearing of its benefits in halting the usual

progression in MS

> disease, reading of many first-hand reports of no recurrence for up

to 5 and

> 6 years in some of these people using a nightly tiny dose of

Naltrexone. In

> reviewing the literature, the lowest dose Naltrexone that had been

used in

> autistic children was 12.5mg, and the researchers were looking for

its use

> as an opioid antagonist, not an immune system stimulant. Since the

> endorphins are an integral part of the immune system, when a tiny

dose of

> naltrexone (3mg for children, 4.5mg for adults) is given between 9-

12pm at

> night (11pm is ideal) there is an attempt for the body to overcome

the

> opioid block and the endorphins rise, to stay elevated throughout

the next

> 18 hours.

>

>

>

> I have just completed an 8-week informal clinical study on 15 of my

ASD

> patients using low-dose naltrexone, or LDN. Several adults

participated

> also, one with Crohn's Disease, one with Chronic Fatigue Syndrome,

and Jack

> and myself as controls, not having any immune disorder that we know

about.

> The dose Dr. Bihari found most efficacious was between 3-4.5mg, so

the

> children were given 3mg and the adults or children over 100 lbs

4.5mg. This

> medication is terribly bitter (causing subjects from previous

studies to

> drop out), and needs to be given once daily only between 9-12pm

(ideally

> 11pm, which is usually about the time parents go to bed). I worked

with Dr.

> Tyrus at Coastal Compounding; he at first created capsules in

these

> two strengths, but then we decided on a transdermal cream which

parents

> could put onto their kids just before parents go to bed - hopefully

the kids

> are long asleep. That way we could adjust the dose easily (some of

the

> tinier kids did better with only 1-1/2mg), the bitter taste was no

problem,

> and it could be put on their bodies while they slept. It has

worked

> wonderfully and was brilliantly executed by Tyrus, with whom I have

worked

> closely on many compounds for ASD kids over the years. A month's

supply is

> $30, a two-month supply is $55.

>

>

>

> I asked parents to report weekly on: Sleep, Appetite, Stools,

Relating,

> General Activity, Cognition, and Language. 8 of the 15 children

have had

> positive responses, and five of these 8 have been nothing short of

> phenomenal according to their parents. The primary positive

responses have

> been in the area of mood, cognition, language, and relating. 5 of

the

> children had equivocal results, some good responses interspersed

with

> complications with gut infections and treatments, so it was

difficult to

> know just what was doing what. One child dropped out because of no

response

> after 4 weeks (my Chelsey, of course, a notorious non-responder),

one child

> dropped out because of vacations and trips, and another stopped

because of

> personal family issues.

>

> No allergic reactions were noted to the cream. The primary side

effect was

> that in the first few days of taking this medicine, the child might

have

> some insomnia and wake up earlier. Even then, most woke up in

better mood.

> Quite a few of the kids had early hyperactive/hyperawake effects,

and this

> was temporary (3-5 days) except for two of the tiny kids, who

finally got

> much better when their dose was decreased. One of these ended up

doing very

> well with only a tiny bit (almost immeasurable) each night, yet it

had a

> definite effect. I would say the most consistent positive report

has been

> happiness and good mood in the kids. I now recommend everyone

start with ¼

> cc, or 1.5mg for a few nights before going on to the ½ cc, which is

3mg.

> The adults will stay on 4.5mg, though 3 may be plenty for some of

them.

>

> The two adults in the study, one with Crohn's and the other with

Chronic

> Fatigue Syndrome, have had very positive responses, and the Crohn's

> participant says she has not had any problems with her gut since

taking

> this. Dr. Bihari has announced a study with 15 Crohn's with all 15

having a

> very positive and sustained excellent reaction to the therapy.

Other than

> feeling a little more erotic (this has been reported in some of the

MS

> patients), Jack and I have not noticed any side effects from the

use at

> 4.5mg nightly. We feel pretty good on it; the mood elevation is

pretty

> universal with everyone who takes it, and increased socialization

had even

> been noted in some earlier studies which used much bigger doses.

No one

> else has done a study of ASD kids with these tiny doses, and no one

to my

> knowledge has used the transdermal application at night for the

endorphin

> rush (pulse) that takes place about 2-4 am. All participants who

completed

> the study have indicated they wish to continue.

>

> This very small and very preliminary study has been positive enough

to

> warrant a more formal study, and I am trying to get Dr. Vojdani at

> Immunosciences interested in participating with some immune testing

to

> verify the supposed T2 to T1 shift that I believe is happening for

at least

> some of the children. However, the doses are tiny, the application

is easy,

> it is non-toxic at these doses, and it is relatively inexpensive,

so I

> suspect we will get lots of informal clinical data from those who

will be

> starting to use it now long before we get a formal study

conducted. This is

> by no means a magic bullet, but I am adding it to my armamentarium

to try to

> get the children as immune-efficient as possible. I would

appreciate

> parents reporting on the lists I monitor; for questions, please do

not post

> or phone me personally, but I will try to address questions on the

CSB

> e-list if other parents or your doctors cannot. There is a website

> www.low dose naltrexone.com that will provide more information to

those

> desiring such.

> To those of you who participated in the study; please feel free to

share on

> the lists any of your feelings, impressions, and results, good,

bad, or

> indifferent - the more we know the better for everyone. I THANK

ALL OF YOU

> SO MUCH for being trusting enough to go along with me in trying

something

> new, and I thank Dr. Tyrus for helping devise a successful

form to use

> in our children. BTW, he has as usual offered to share his formula

with any

> other compounding pharmacy who wishes to call him, 912-354-5188.

Those of

> you in my study may want to transfer your prescription to your

local

> compounder to save shipping charges.

>

> Jaquelyn McCandless, M.D.

>

> 7-2-05