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From: MSIF Mailer <mailer@...>Date: June 29, 2004 7:20:31 AM EDTjayneadler@...Subject: World of MS Update ServiceWorld of MS Update Service, 29 Jun 2004====================World of MS Update ServiceMSIF News====================MS in Focus Issue 4 Online - Emotions and Cognition--------------------Multiple sclerosis affects more than just physical abilities. It can change the way people feel about themselves and alter their cognitive functions. For many, the emotional and cognitive effects of the disease represent its greatest challenges.http://www.msif.org/en/publications/ms_in_focus/index.htmlResearch News====================Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.--------------------Interferon beta exhibits inhibitory effects on the activity of matrix metalloproteinases (MMPs), while statins exert anti-inflammatory and pro-inflammatory effects. This dual mechanism of action should be considered, given the recent interest in developing these drugs for treatment of MS.http://www.msif.org/goemail.rm?id=421An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study.--------------------The authors found that individuals who will develop MS exhibit an altered immune response against the Epstein-Barr virus (EBV), expecially in the 5-year period preceding MS onset.http://www.msif.org/goemail.rm?id=422Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes.--------------------The authors demonstrated that vitamin D receptor genes are linked with MS risk and outcome in 419 cases and 422 controls.http://www.msif.org/goemail.rm?id=423Multiple sclerosis and occult gluten sensitivity.--------------------Two atypical patients with a MS-like illness and evidence of occult celiac disease (CD) were diagnosed by the authors. This prompted screening of a further 49 unselected MS cases for serologic evidence of CD. Findings suggested that anti-gliadin antibody (especially IgG isotype) can be a nonspecific finding in MS.http://www.msif.org/goemail.rm?id=424A Study of Promoter and Intronic Markers of ApoI/Fas Gene and the Interaction with Fas Ligand in Relapsing Multiple Sclerosis.--------------------The authors found a weak association between multiple sclerosis and Fas-MaeI genotypes in 215 healthy individuals and 312 relapsing MS patients of Spanish extraction.http://www.msif.org/goemail.rm?id=425Methods for expected value of information analysis in complex health economic models: developments on the health economics of interferon-beta and glatiramer acetate for multiple sclerosis.--------------------More sophisticated metamodelling approaches might obtain greater accuracy in expected value of perfect information estimation. Programming requirements, software availability and statistical accuracy should be considered when choosing between metamodelling techniques.http://www.msif.org/goemail.rm?id=426Comparative Analysis of the CD19(+) and CD138(+) Cell Antibody Repertoires in the Cerebrospinal Fluid of Patients with Multiple Sclerosis.--------------------A comparative analysis of the CD19(+) and CD138(+) cell antibody repertoires was performed in the cerebrospinal fluid of two patients with MS and one patient with clinically isolated syndrome. In all three patients the CD138(+) IgG repertoire was more restricted.http://www.msif.org/goemail.rm?id=427A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response.--------------------The epitope MOG92-106, which is a target for antibodies and is located in the myelin oligodendrocyte glycoprotein (MOG), has the specific capacity to induce a widespread autoimmune response in mice.http://www.msif.org/goemail.rm?id=428Acute promyelocytic leukemia in a patient with multiple sclerosis following treatment with mitoxantrone.--------------------The authors describe a patient with MS who developed leukaemia after treatment with mitoxantrone.http://www.msif.org/goemail.rm?id=429----------------------------------------Thank you for using the World of MS update service that is provided by the Multiple Sclerosis International Federation (MSIF).MSIF presents, in this user friendly format, the latest MS research findings published within medical and scientific journals.However MSIF is not able to validate or be held responsible for this research, nor can MSIF comment on its accuracy or relevance.The 'Research News' section on the World of MS website is generously funded by the UK MS Society and is compiled with the support of theInstitute of Neurology, University College, London, UK.*Please do not reply to this email*If you have any queries about the site or the Update Service please contact us at info@...To unsubscribe or edit your profile/details/subscription please go to:http://www.msif.org/applications/people_profiles/