Liquid LDN - does it keep efficacy?

[Guest guest]

Hi everyone,

I'm just starting LDN. I liquify 25mg Naltrexone cut from a 50mg

ReVia tablet by dissolving it in distilled water. I then take 4.5ml

and further wash it down with water. I refrigerate the rest.

Question: Will the refrigerated portion of my liquified Naltrexone

maintain its effectiveness?

I've read anecdotal accounts that it does maintain its effectiveness,

but is there any scientific evidence that this is true?

My pharmacist said to just discard whatever is not used immediately.

I wonder whether he really knows for sure whether this is really

necessary.

Essentially, I am looking for some scientific proof on whether

Naltrexone loses its effectiveness when liquified in distilled water,

and then refrigerated. Your insights are appeciated! I apologize if

this topic was previously asked and answered already.

TIA

Leo from Southern California, USA

[Guest guest]

here is what Larry F the pharmacist had to say:

STABILITY OF NALTREXONE From: " Larry J. Frieders " <larry@t...>

Date: Wed Mar 3, 2004 5:44 pmSubject:

NOT 1 day... NOT 1 week...BUT a MONTH or MORE! Naltrexone is quite

stable in water. I am quoting from Trissel's book, " Stability of

Compounded Formulations " , Second Edition, page 266 " Stability-

indicating HPLC analysis found less than 10% loss within 90 days at

either 4 degrees C or 25 degrees C; most samples exhibited no

loss. .... The recommended shelf lives of 30 and 60 days stored at

25 degrees C and 4 degrees C, respectively. " This is a reference

book that every compounder OUGHT to have on hand. 4 degrees C is

refrigeration and 25 degrees C is room temperature. We make a lot

of naltrexone solutions for people who need to adjust their doses.

The most popular strength is 1mg per ml. We supply a syringe with

which the patient can measure the correct dose. It is bitter so it

needs to be mixed with something (unless you have strong taste

buds). Nobody has ever complained that it " stopped working " .

Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora,

IL 60506 630-859-0333 FAX 630-859-0114 Sample newsletter

http://www.theCompounder.com/NL-Sample.html

-- In low dose naltrexone , leosab@c... wrote:

> Hi everyone,

>

>

> Question: Will the refrigerated portion of my liquified Naltrexone

> maintain its effectiveness?

>

> >

> Essentially, I am looking for some scientific proof on whether

> Naltrexone loses its effectiveness when liquified in distilled

water,

> and then refrigerated. Your insights are appeciated! I apologize

if

> this topic was previously asked and answered already.

>

> TIA

>

> Leo from Southern California, USA

[Guest guest]

Excellent reply. Thank you very much!

Leo

> > Hi everyone,

> >

> >

> > Question: Will the refrigerated portion of my liquified

Naltrexone

> > maintain its effectiveness?

> >

> > >

> > Essentially, I am looking for some scientific proof on whether

> > Naltrexone loses its effectiveness when liquified in distilled

> water,

> > and then refrigerated. Your insights are appeciated! I apologize

> if

> > this topic was previously asked and answered already.

> >

> > TIA

> >

> > Leo from Southern California, USA