Guest guest Posted July 19, 2004 Report Share Posted July 19, 2004 Below are some random observations, which need further development. Copaxone is a random peptide mixture of 4 amino acids, glutamic acid-alanine-tyrosine-lysine. The recent NZ study used the peptide, glycine-proline-glutamic acid. In the study, this peptide blocks kainate receptors through which the amino-acid glutamic acid acts. The two peptides share one amino-acid, glutamic acid. Tyrosine in copaxone is required to build neurotransmitters. Glycine in the NZ peptide, is an important neurotransmitter. ---------------------------------------------------------- Once inside the brain, it is very likely that these peptides are broken down into constituent amino-acids by enzymes. This would increase the levels of the neurotransmitter amino-acids, gly and tyr. ------------------------------------------------------------------ The enkephalins share the same first five amino-acids (Tyr-Gly-Gly- Phe-Leu) with the endorphins. These are the peptide hormones that are blocked by LDN. ------------------------------------------------------------- So what does it all mean ?. I guess the right combination of amino- acid chains may block MS. Copaxone is a random mix, so perhaps over long periods of therapy, one does accumulate the right sequence of peptides by chance. The NZ study may have hit upon a better sequence (gly-pro-glu) or the right receptor (kainate) that needs to be blocked. This is all speculation of course, but that has not stopped me before. Aegis Quote Link to comment Share on other sites More sharing options...
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