Guest guest Posted June 15, 2004 Report Share Posted June 15, 2004 I have noticed and so has my trainer a major increase in strength in the past 2 weeks. The only thing I have changed is that I drink Lipton decaf Green tea at room temp. during the day instead of water and coffee. Did a Google on Green Tea and maybe this is not a coincidence. Does anyone else drink green tea and noticed anything? Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells. Source: Redox Rep 2002;7(3):171-177Author(s): Nie G, Cao Y, Zhao B.Institute: Laboratory of Visual Information Processing, Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, Beijing, China.Published: 8/01/02 Abstract:Green tea polyphenols exert a wide range of biochemical and pharmacological effects, and have been shown to possess antimutagenic and anticarcinogenic properties. Oxidative stress is involved in the pathogenesis of Parkinson's disease. However, although green tea polyphenols may be expected to inhibit the progression of Parkinson's disease on the basis of their known antioxidant activity, this has not previously been established. In the present study, we evaluated the neuroprotective effects of green tea polyphenols in the Parkinson's disease pathological cell model. The results show that the natural antioxidants have significant inhibitory effects against apoptosis induced by oxidative stress. 6-Hydroxydopamine (6-OHDA)-induced apoptosis in catecholaminergic PC12 cells was chosen as the in vitro model of Parkinson's disease in our study. Apoptotic characteristics of PC12 cells were assessed by MTT assay, flow cytometry, fluorescence microscopy and DNA fragmentation. Green tea polyphenols and their major component, EGCG at a concentration of 200 & mgr;M, exert significant protective effects against 6-OHDA-induced PC12 cell apoptosis. EGCG is more effective than the mixture of green tea polyphenols. The antioxidant function of green tea polyphenols may account for this neuroprotective effect. The present study supports the notion that green tea polyphenols have the potential to be effective as neuropreventive agents for the treatment of neurodegenerative diseases. Abstract Archived at: http://www.als-tdf.org/alstdf/research/hubben/viewarticle.asp?id_article=611 [This message has been edited by whubben (edited 12-09-2002).] Quote Link to comment Share on other sites More sharing options...
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