Beta endorphins, LDN and Nausea

[Guest guest]

Hi,

The article below got me to wondering. Since taking LDN, I have

been nauseous - partcularly in the morning. I have used both avicel

and calcium carbonate as filler and it doesn't seem to mater except

that the avicel is worse. The only time I can remember feeling this

way was during the early months of my pregnancies many years ago. I

have been post menopausal for quite some time. I have tried taking

LDN during the day with food and that does not cause nausea,

Has this happened to others? Is it possible that the nausea might

be related to some homonal pregnancy type changes? Any suggestions

on what to do about it? Any comments Thanks.

Daryssa

> Hi All,

>

> I found an interesting research article about pregnancy and MS. It

says

> that during pregancy the Th2 cells are upregulated and Th1 cells

> downregulated.

>

> The same thing happens when beta endorphine level is elevated by

> LDN.

>

> -----------------------------------------

>

> J Neurol Sci. 2004 Jul 15;222(1-2):21-7. Related Articles,

Links

>

>

> Th1/Th2 cytokine patterns and clinical profiles during and after

> pregnancy in women with multiple sclerosis.

>

> Al-Shammri S, Rawoot P, Azizieh F, AbuQoora A, Hanna M, Saminathan

> TR, Raghupathy R.

>

> Department of Medicine, Faculty of Medicine, Kuwait University,

P.O. Box

> 24923, Safat 13110, Kuwait.

>

> Pregnancy in multiple sclerosis (MS) patients is associated with a

lower

> risk of progression and lower rate of exacerbation. These

beneficial

> effects are reversed postpartum. Considering that the pathogenesis

of

> MS appears to involve cell-mediated immune reactivity, and that

> pregnancy is accompanied by a depressed cell-mediated immunity, it

> has been proposed that the lower relapse rate and risk of

progression

> of MS during pregnancy may be due to a pregnancy-associated down-

> regulation of cell-mediated immunity. In addition, pregnancy

results in a

> shift towards a T helper (Th) 2 cytokine profile, which is

presumably

> protective for MS. This study was aimed at investigating the

> relationship between clinical status of MS and cytokine levels in

eight

> patients with MS who were followed through pregnancy and after

> delivery. Peripheral blood lymphocytes from these women were

> stimulated with a mitogen at different time points during and

after

> gestation and the levels of Th1 cytokines (IFNgamma, TNFalpha) and

> Th2 cytokines (IL-4, IL-10) were estimated by ELISA. It was

established

> that six of the eight MS patients studied showed a distinct shift

from a

> Th2 cytokine bias during pregnancy towards a Th1 cytokine bias

after

> delivery. These results suggest a possible association between

> decreased incidence of exacerbation of MS in pregnancy and a

> pregnancy-induced shift towards Th2 cytokine bias.