Re: IgE scores after starting Xolair

May 4, 2007

I am going to a meeting/lecture, in a few weeks, with

a Xolair " Dr. Speaker " . I am going to make apoint

to ask him to put this in to understandable English

for all us non medical people. I'll let every one

know what he says!!

--- pyle456 <coachmac@...> wrote:

> My understanding is that Genentech is the only place

> that they can do

> an IgE test that separates the Xolair-bound from the

> still free-

> floating IgE, and that that test is currently not

> available in the

> marketplace. So our docs are using tests that are

> measuring both the

> Xolair-bound and the free-floating IgE, although

> apparently once the

> IgE binds to the mast cell, it doesn't register on

> the currently

> available tests. Most highly allergic folks are

> continuing to

> manufacture new IgE, which always has to be bound to

> new Xolair.

> That's why it can take six months to a year for some

> folks to see

> improvement before the rate at which Xolair is

> binding to new IgE

> exceeds (at least a little bit) the rate at which

> our bodies are

> manufacturing new IgE. It's also my understanding

> (but I may be

> wrong) that there is a theory that after some number

> of years on

> Xolair patients may be able to stop taking it and

> still see benefits

> long term. I suppose, however, that that would be

> folks who stop

> manufacturing new IgE (lucky devils). I don't hold

> out hope for that

> myself, since I see a symptom increase after just a

> week or so being

> late on my Xolair if my scrip is delayed getting

> renewed. I do think

> that Xolair is teaching scientists a lot about

> IgE-mediated disease

> and even those who didn't tolerate Xolair well have

> a lot to look

> forward to regarding other options for treatment.

>

> One more thing - I have seen nine different

> allergists in my life

> that I can remember. I have had IgE scores

> (pre-Xolair) range from

> high 500s to 800. It's not a permanent number.

>

> Addy

> Group co-owner and resident Soap Box Queen

> reminding you that if you haven't been to jibjab.com

> and watched the

> video " the Drugs I Need " that you haven't lived.

>

> PS - Terry - how many days until basketball season

> starts?????

>

__________________________________________________

May 11, 2007

Addy - There was a previous post to the effect that xolair contributes to

sinusitis and sinus infections. I continually have sinusitis and I'm prone

to sinus infections, having had MRSA and several other infections up there.

What's your or the experts take on this. I've been skipping my xolair

injections for the past two sessions because of some other infections that

got me down, and I'm prone to picking up practically any infection that

comes down the pike. If the xolair might contribute to that problem, I'm

wondering if I should resume. I've been on antibiotics, off and on since

last fall and I don't want to risk making things worse. Whatcha think?

P.S. Addy - if ya asks the guys in the NBA, they'll tell you it ain't over

yet. I'm really looking forward to Nov, though, because I think both Duke

teams are going to be fun and fascinating. By the way, it recently came out

that word got out during the NCAA tournament that Coach G might be going to

Texas, which probably affected the girls' concentration and play. Texas

apparently didn't have the class to wait until the tourney was over to

approach her.

Terry

----- Original Message -----

From: pyle456

Sent: Friday, May 04, 2007 7:06 AM

Subject: [ ] IgE scores after starting Xolair

My understanding is that Genentech is the only place that they can do

an IgE test that separates the Xolair-bound from the still free-

floating IgE, and that that test is currently not available in the

marketplace. So our docs are using tests that are measuring both the

Xolair-bound and the free-floating IgE, although apparently once the

IgE binds to the mast cell, it doesn't register on the currently

available tests. Most highly allergic folks are continuing to

manufacture new IgE, which always has to be bound to new Xolair.

That's why it can take six months to a year for some folks to see

improvement before the rate at which Xolair is binding to new IgE

exceeds (at least a little bit) the rate at which our bodies are

manufacturing new IgE. It's also my understanding (but I may be

wrong) that there is a theory that after some number of years on

Xolair patients may be able to stop taking it and still see benefits

long term. I suppose, however, that that would be folks who stop

manufacturing new IgE (lucky devils). I don't hold out hope for that

myself, since I see a symptom increase after just a week or so being

late on my Xolair if my scrip is delayed getting renewed. I do think

that Xolair is teaching scientists a lot about IgE-mediated disease

and even those who didn't tolerate Xolair well have a lot to look

forward to regarding other options for treatment.

One more thing - I have seen nine different allergists in my life

that I can remember. I have had IgE scores (pre-Xolair) range from

high 500s to 800. It's not a permanent number.

Addy

Group co-owner and resident Soap Box Queen

reminding you that if you haven't been to jibjab.com and watched the

video " the Drugs I Need " that you haven't lived.

PS - Terry - how many days until basketball season starts?????

May 11, 2007

I don't know. For me personally, my every 4-6 week sinus infections

are a thing of the past. Now I get about two a year. Xolair has

really improved my allergic sinus issues. However, I have never had

any sinus issues that were not related to allergy (well, other than

weather), so I can't say that if I had some other issue whether or

not Xolair might exacerbate that or at least not help it.

Addy

PS - Absolutely that affected our play. Still mad about that.

--- In , " Terry " <onabeach@...>

wrote:

>

> Addy - There was a previous post to the effect that xolair

contributes to

> sinusitis and sinus infections. I continually have sinusitis and

I'm prone

> to sinus infections, having had MRSA and several other infections

up there.

> What's your or the experts take on this. I've been skipping my

xolair

> injections for the past two sessions because of some other

infections that

> got me down, and I'm prone to picking up practically any infection

that

> comes down the pike. If the xolair might contribute to that

problem, I'm

> wondering if I should resume. I've been on antibiotics, off and on

since

> last fall and I don't want to risk making things worse. Whatcha

think?

>

> P.S. Addy - if ya asks the guys in the NBA, they'll tell you it

ain't over

> yet. I'm really looking forward to Nov, though, because I think

both Duke

> teams are going to be fun and fascinating. By the way, it recently

came out

> that word got out during the NCAA tournament that Coach G might be

going to

> Texas, which probably affected the girls' concentration and play.

Texas

> apparently didn't have the class to wait until the tourney was over

to

> approach her.

>

> Terry

>

> ----- Original Message -----

> From: pyle456

>

> Sent: Friday, May 04, 2007 7:06 AM

> Subject: [ ] IgE scores after starting Xolair

>

> My understanding is that Genentech is the only place that they

can do

> an IgE test that separates the Xolair-bound from the still free-

> floating IgE, and that that test is currently not available in the

> marketplace. So our docs are using tests that are measuring both

the

> Xolair-bound and the free-floating IgE, although apparently once

the

> IgE binds to the mast cell, it doesn't register on the currently

> available tests. Most highly allergic folks are continuing to

> manufacture new IgE, which always has to be bound to new Xolair.

> That's why it can take six months to a year for some folks to see

> improvement before the rate at which Xolair is binding to new IgE

> exceeds (at least a little bit) the rate at which our bodies are

> manufacturing new IgE. It's also my understanding (but I may be

> wrong) that there is a theory that after some number of years on

> Xolair patients may be able to stop taking it and still see

benefits

> long term. I suppose, however, that that would be folks who stop

> manufacturing new IgE (lucky devils). I don't hold out hope for

that

> myself, since I see a symptom increase after just a week or so

being

> late on my Xolair if my scrip is delayed getting renewed. I do

think

> that Xolair is teaching scientists a lot about IgE-mediated

disease

> and even those who didn't tolerate Xolair well have a lot to look

> forward to regarding other options for treatment.

>

> One more thing - I have seen nine different allergists in my life

> that I can remember. I have had IgE scores (pre-Xolair) range from

> high 500s to 800. It's not a permanent number.

>

> Addy

> Group co-owner and resident Soap Box Queen

> reminding you that if you haven't been to jibjab.com and watched

the

> video " the Drugs I Need " that you haven't lived.

>

> PS - Terry - how many days until basketball season starts?????

>

May 12, 2007

what else is there but weather and allergy? rain creates mold and winds

associated with rains create problems by stirring things up.

pyle456 <coachmac@...> wrote: I don't know. For me

personally, my every 4-6 week sinus infections