IgE scores after starting Xolair

[Guest guest]

My understanding is that Genentech is the only place that they can do

an IgE test that separates the Xolair-bound from the still free-

floating IgE, and that that test is currently not available in the

marketplace. So our docs are using tests that are measuring both the

Xolair-bound and the free-floating IgE, although apparently once the

IgE binds to the mast cell, it doesn't register on the currently

available tests. Most highly allergic folks are continuing to

manufacture new IgE, which always has to be bound to new Xolair.

That's why it can take six months to a year for some folks to see

improvement before the rate at which Xolair is binding to new IgE

exceeds (at least a little bit) the rate at which our bodies are

manufacturing new IgE. It's also my understanding (but I may be

wrong) that there is a theory that after some number of years on

Xolair patients may be able to stop taking it and still see benefits

long term. I suppose, however, that that would be folks who stop

manufacturing new IgE (lucky devils). I don't hold out hope for that

myself, since I see a symptom increase after just a week or so being

late on my Xolair if my scrip is delayed getting renewed. I do think

that Xolair is teaching scientists a lot about IgE-mediated disease

and even those who didn't tolerate Xolair well have a lot to look

forward to regarding other options for treatment.

One more thing - I have seen nine different allergists in my life

that I can remember. I have had IgE scores (pre-Xolair) range from

high 500s to 800. It's not a permanent number.

Addy

Group co-owner and resident Soap Box Queen

reminding you that if you haven't been to jibjab.com and watched the

video " the Drugs I Need " that you haven't lived.

PS - Terry - how many days until basketball season starts?????