Re: Other Med Override Xolair? Questions! Inflammation?

[Guest guest]

One more thought about high levels of inflammation .... For years I

was told it was probably due to my allergies. So, the question:

How many of you with heavy duty allergies and asthma have high levels

of inflammation? Say, high C-Reactive Protein, Sedimentation Rate,

Comlement C3 Serum, Complement C4 Serum, PTT-LA Lupus ????? Other?

Is this in fact typical of very allergic people? Does Xolair change

our response on any of these tests of inflammation?

I would think that if I, the allergic kid, have high inflammation

then others must have it too.

Thanks, all!

--- In , SD Designer <instdesgn1@...>

wrote:

>

> I finally took my first dose of methotrexate on Wed. night for

seronegative rheumatoid arthritis and had a very unpleasant

response. It was like a combination of a very bad allergy attack and

the beginnings of an infection. My nose bled, my head was stopped

up, my nose, tongue, throat were " on fire " , I was dizzy (still am

somewhat), my nose ran clear mucous while I was asleep (all over when

I woke up) and I felt like I was completely dried up. My brain was

absolutely dulled out - couldn't remember how to get to certain

places around town. This sounded a little like some of my reactions

to antihistamines but there was no antihistamine involved in several

weeks.

>

> Is it possible for another drug to override the benefit of

Xolair? This reaction was something I would have had last fall (a

year ago) if I had spent the day doing heavy gardening - dirt,

pollen, mold, vegetation - all major nasty triggers, but, in fact, I

had not been exposed to any of the more severe triggers.

Furthermore, I've been on Xolair since March and noticed this fall

that I'm definitely better off than I was a year ago at this time.

Not free from allergy (still take Advair and Spiriva every day) but

definitely more comfortable with fewer symptoms.

>

> The only difference was the methotrexate which is known to cause

infection in some people. Even my upper lip was partially swollen

and a little sore spot got much more sore. But, I didn't think that

my experience was at all the typical experience w/methotrexate - in

fact, it seemed very allergic. So, I'm wondering if methotrexate

simply removed the benefit of Xolair or if I really did have an

allergic reaction to the other med because I haven't been on Xolair

long enough for complete protection (if that indeed ever happens)?

>

> The rheumy gave me this drug because of my very high test results

re inflammation plus definite arthritic history. She didn't know if

the high inflammation was from asthma (life long allergies) or

arthritis. That's another $64 question - how does one

differentiate? I'm hard to treat because of all my allergies and it

looks like I'm going to have to come up with my own treatment.

>

> Questions, questions, questions!

>

>

> ---------------------------------

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>

>

[Guest guest]

The body's inflammatory response is very complicated.

Xolair blocks IgE alone which has nothing to do with

some of the other mediators you are mentioning. Fran

could likely shed more light on this.

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