Re: xolair shots for 5 years not working

October 8, 2007

My allergies/asthma is not as severe as yours but I am beginning to wonder if I

am becoming addicted/dependent/building up a tolerance to Xolair. I started on

150/mos with minimal benefit. I was increased to 150/75 alternating every 2

weeks and at one point felt cured. Recently, my symptoms have been getting

steadily worse and it feels like the shot lasts for only a few days. Now, when

I get into bed I experience tremendous itching, tightness, and mucus production

(I'm highly allergic to dust mites). I just have a sneaky feeling that Xolair

is losing its effectiveness. I could go up to 150/150 every two weeks but what

if the same thing happens a few months/years down the road? What if that

doesn't help?

I'm not scheduled to see my Doc til March but I'm going to ask the nurses the

next time I go into the office. I imagine they won't know but it doesn't hurt

to ask.

I haven't been able to find anything about this on the internet. The drug

probably hasn't been on the market long enough for this type of condition to be

noted.

momlago <momlago@...> wrote:

Hi,

I have severe asthma and I have been steroid dependent for the last

13 years. I have been able to get down to 10mg every other day and

for the last five years I have been taking xolair once a mounth. I

not only did not see a difference with the xolair but it seems that I

now need to take it twice a month. Five years ago I went on

permanant disabillity in the hope that I would be able to avoid

hospitalization that was every two months. Around the same time I

began take xolair shots. The only thing I noticed at the time was

that I was better able to control my symptoms at home, but five years

later I am again needing hospitalization averaging every two to three

months, not to mention that I am unable to get back to my maintanence

level of prednisone. I am wondering if there is anyone else out

there suffering like this. I have so many side effects probablly

from the prednisone, but I am miserable none the less. It almost

feels like my body has become addicted to xolair. Prior to taking

the shot I was highly allergic to almost everything but I don't

remember the sneezing, itchy all aver my body, rashes, and itchy nose

like I feel now. My allergy symptoms seems much more pronounced

almost as if my allergies have gotten worse instead of better.

In addition to allergies I am asperin sensitive and I suffer from

sinus desease and reflux. I have been told I have triad asthma which

makes it harder to control

If there is anybody out there suffering like me I would really love

to hear from you

Margarita

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October 8, 2007

Hi,

I am an asthmatic who has been on Xolair once a month and then my doctor began

thinking I needed a little or lot more Xolair. I do very well on Xolair, but

lately have been having some more problems and she does not want me on

predisone. So she decided to make the Xolair two shots every 2 weeks, instead

of once a month. I have been doing well with this but am on my other meds

besides. I think there may be something in my convent that sets me off sneezing

and coughing. I am not sure what it is maybe all of the carpet and

reconstruction dust that does not or did not get cleaned when they finished the

construction. When I am not in my home I am better but there is not change in

my future. I hope this gives you some hope.

Breathing better,

Sr. Volz, C.R.