NSAID reaction allergic?

February 7, 2008

Does anyone know if a reaction to NSAIDs (aspirin, ibuprofen, etc) is a true

IgE reaction and that Xolair would help reduce it, or it is a non-IgE

reaction?

I am trying to figure out if I can take Ibuprofen again after years of it

triggering asthma. I have just taken Celebrex for 3 days without an asthma

flare. We are unsure if it is because I wouldn't react anyways or if Xolair

has reduced the possible reaction. I would love to be able to take ibuprofen

instead of having to pay for prescription Celebrex.

I need to have some surgery on my foot but can't in the next few months. So

I am trying to at least be a bit more comfortable until the surgery and

would prefer to not spend a ton doing so.

Thanks,

B. - who needs surgery of some sort it seems every 2 years or 10,000

awake hours whichever comes first

February 8, 2008

Nobody has ever been able to show that ASA (aspirin-sensitive asthma)

is a true allergy involving IgE. Instead, there is growing evidence

that ASA is due to a complex reaction involving the nervous system

and hormonal systems. Maybe if more folks like you become able to

tolerate aspirin and other NSAIDs during Xolair treatment, it will

lead to an eventual proof that it is a true allergy after all!

>

> Does anyone know if a reaction to NSAIDs (aspirin, ibuprofen, etc)

is a true

> IgE reaction and that Xolair would help reduce it, or it is a non-

IgE

> reaction?

>

> I am trying to figure out if I can take Ibuprofen again after years

of it

> triggering asthma. I have just taken Celebrex for 3 days without an

asthma

> flare. We are unsure if it is because I wouldn't react anyways or

if Xolair

> has reduced the possible reaction. I would love to be able to take

ibuprofen

> instead of having to pay for prescription Celebrex.

>

> I need to have some surgery on my foot but can't in the next few

months. So

> I am trying to at least be a bit more comfortable until the surgery

and

> would prefer to not spend a ton doing so.

>

> Thanks,

>

> B. - who needs surgery of some sort it seems every 2 years or

10,000

> awake hours whichever comes first

>

February 8, 2008

,

NSAID reactions are not IgE-mediated. However, reducing your

susceptibility to IgE reactions MAY also reduce the likelihood that

you'll react to a non-IgE trigger, as your mast cells become more

stable because they are not being triggered all the time. However,

you'd have to be very careful testing it out, as there is no way to