Re: not breathing well; diseased lungs - ? airway remodeling

[Guest guest]

Thanks for the info.  I was relating what the docs had said when I asked what

had happened to my lungs.  I have read the expression " lung remodeling " before

and even though I can't read any of the tests that have been done, including CT

scans of my lungs, I suspect that is what has happened to my lungs and the doc

may have said damaged, not diseased which is a big difference.  Whatever is

wrong with the lungs the xolair has helped me breathe easier overall.

 

From: pyle456 <jamcculloch2@...>

Subject: [ ] not breathing well; diseased lungs - ? airway remodeling

Date: Sunday, October 12, 2008, 7:13 PM

The following info comes from a 2004 article in the ls of

Clinical & Laboratory Science 34:138-142 (2004)

Pharmacological Treatment of Airway Remodeling: Inhaled

Corticosteroids or Antileukotrienes?

Graziano Riccioni, Carmine Di Ilio and Nicolantonio D'Orazio

Unit of Human Nutrition, Department of Biomedical Sciences,

D'Annunzio University, Chieti, Italy

Chronic stable asthma is characterized by inflammation of the airway

wall, with abnormal accumulation of basophils, eosinophils,

lymphocytes, mast cells, macrophages, dendritic cells, and

myofibroblasts. Airway inflammation is not limited to severe asthma,

but is also found in mild and moderate asthma. .... The term " airway

remodeling " in bronchial asthma refers to structural changes that

occur in conjunction with, or because of, chronic airway

inflammation. Airway remodeling results in alterations in the airway

epithelium, lamina propria, and submucosa, leading to thickening of

the airway wall. Consequences of airway remodeling in asthma include

incompletely reversible airway narrowing, bronchial hyper-

responsiveness, airway edema, and mucus hypersecretion; these effects

may predispose subjects with asthma to exacerbations and even death

due to airway obstruction. To avoid this progression, it is important

to follow an adequate treatment aimed at interacting and modifying

the inflammatory process....

[Guest guest]

great article! do you have a link for it by chance? i have a friend

that i want to show this to. she insists that her daughter doesn't

need inhaled steroids and preventative meds since she's not always

symptomatic, i strongly disagree due to the damage that can be done.

--- In , " pyle456 " <jamcculloch2@...>

wrote:

>

>

> The following info comes from a 2004 article in the ls of

> Clinical & Laboratory Science 34:138-142 (2004)

>

> Pharmacological Treatment of Airway Remodeling: Inhaled

> Corticosteroids or Antileukotrienes?

> Graziano Riccioni, Carmine Di Ilio and Nicolantonio D'Orazio

> Unit of Human Nutrition, Department of Biomedical Sciences,

> D'Annunzio University, Chieti, Italy

>

> Chronic stable asthma is characterized by inflammation of the

airway

> wall, with abnormal accumulation of basophils, eosinophils,

> lymphocytes, mast cells, macrophages, dendritic cells, and

> myofibroblasts. Airway inflammation is not limited to severe

asthma,

> but is also found in mild and moderate asthma. .... The

term " airway

> remodeling " in bronchial asthma refers to structural changes that

> occur in conjunction with, or because of, chronic airway

> inflammation. Airway remodeling results in alterations in the

airway

> epithelium, lamina propria, and submucosa, leading to thickening of

> the airway wall. Consequences of airway remodeling in asthma

include

> incompletely reversible airway narrowing, bronchial hyper-

> responsiveness, airway edema, and mucus hypersecretion; these

effects

> may predispose subjects with asthma to exacerbations and even death

> due to airway obstruction. To avoid this progression, it is

important

> to follow an adequate treatment aimed at interacting and modifying

> the inflammatory process....

>