Re: JEAN xolair raise IgE (was Allergies, Asthma, Arthritis....)

[Guest guest]

as best as i understand it, the IgE level appears to increase

because its measuring the amount of " bound IgE " (the part that

xolair already worked on) as well as the new " free floating IgE "

(the part that your body made since your last dose of xolair). your

body continues to make new IgE. xolair does its best to keep up

with it.

you can see this post

/message/6289 for a

better explanation. also, you might want to do a message search

for " free floating IgE " for more information about it.

heather

> > Ok, first the Plaquenil shouldn't really effect your allergies.

It is a T-cell modulater and if

> > anything might improve some of your inflammatory symptoms

associated with your

> > allergies or asthma. The raise in IgE is not so unusual while

being on Xolair. How long have

> > you been on it? While your IgE off Xolair was moderately high

(mine was 345 before), it

> > doesn't necessarily correlate to allergic reactions. Did you

have certain antigens that

> > promoted your asthma episodes? The reason why I ask is because

if you still needed all

> > the other meds along with Xolair to keep your asthma somewhat

controlled, then it wasn't

> > controlled entirely as a result of anti-IgE. So, your flare-up

now might be driven for other

> > reasons than IgE. Anyway, the arthritis might be playing a role

in exacerbations.

> >

> >

> > --- In , " instdesgn1 " <instdesgn1@>

wrote:

> > >

> > > Ok, I'm back at it again with arthritis meds along with my

Xolair and

> > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > >

> > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

year ago

> > > and after having a bad experience with methotrexate (which is

known to

> > > cause lung disease although others on this board have gotten

along ok

> > > w/it) I was afraid to take Plaquenil. The stiffness and pain

finally

> > > drove me to start it 4 nights ago at just 50 mgs once in the

evening.

> > > It's normally prescribed at 200 mgs twice a day. I'm nervous

because I

> > > have a long history of unpleasant drug side effects.

> > >

> > > While consulting w/my pulmo recently I thought she said

something about

> > > the Plaquenil helping (as in making better) one of my allergic

> > > complaints so I assume that the anti-inflammatory properties

of

> > > Plaquenil must reduce the allergic inflammation also?

> > >

> > > Again, has anyone tried Plaquenil who has severe allergies (My

IgE was

> > > 409 before Xolair and on Xolair over 1200)???? I've been

having a

> > > rather bad time for several weeks - can hear myself wheezing

softly

> > > (actually thought it was the cat purring until I held my

breath and

> > > noticed the cat " stopped " purring!!!) and even my hubby can

hear it.

> > > So, the current treatments are not really enough to keep the

allergies

> > > truly under control right now.

> > >

> > > I guess that theoretically the dose is so low on Plaquenil

that it

> > > shouldn't have any effect although I think it is causing

nightmarish

> > > disturbing dreams. I thought I was a bit more irritable too

plus there

> > > was decreasing nausea the first 3 nights. On the other hand,

I'm

> > > hoping I'll be able to work up gradually to the normal dose.

It would

> > > be good to control two different diseases (although several

docs have

> > > told me that arthritis, allergies, and asthma are all related)

at the

> > > same time.

> > >

> > > It's doubtful that any influence on Xolair or vice versa is

known since

> > > Xolair is so new and it works on different systems (I assume)

and in a

> > > completely different way.

> > >

> > > Plaquenil comments, anyone?

> > > Thx

> > >

> >

> >

> >

>

[Guest guest]

yup! 's got that right!

The " average blood test " that checks one's IgE level can not differentiate

between the bound and un bound IgE. So if someone is on Xolair and they get

their IgE levels checked it looks like there levels have trippled -+. There are

quite a few people that my allergists treats who have their " normal " IgE levels

in the 6,000 range. Think there is also some one in here who's level was like

45,000 ( yup....read that right!)

From: heather <heaven1975@...>

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

Date: Thursday, May 22, 2008, 2:43 PM

as best as i understand it, the IgE level appears to increase

because its measuring the amount of " bound IgE " (the part that

xolair already worked on) as well as the new " free floating IgE "

(the part that your body made since your last dose of xolair). your

body continues to make new IgE. xolair does its best to keep up

with it.

you can see this post

http://health. groups.. com/group/ / message/6289 for a

better explanation. also, you might want to do a message search

for " free floating IgE " for more information about it.

heather

> > Ok, first the Plaquenil shouldn't really effect your allergies.

It is a T-cell modulater and if

> > anything might improve some of your inflammatory symptoms

associated with your

> > allergies or asthma. The raise in IgE is not so unusual while

being on Xolair. How long have

> > you been on it? While your IgE off Xolair was moderately high

(mine was 345 before), it

> > doesn't necessarily correlate to allergic reactions. Did you

have certain antigens that

> > promoted your asthma episodes? The reason why I ask is because

if you still needed all

> > the other meds along with Xolair to keep your asthma somewhat

controlled, then it wasn't

> > controlled entirely as a result of anti-IgE. So, your flare-up

now might be driven for other

> > reasons than IgE. Anyway, the arthritis might be playing a role

in exacerbations.

> >

> >

> > --- In , " instdesgn1 " <instdesgn1@ >

wrote:

> > >

> > > Ok, I'm back at it again with arthritis meds along with my

Xolair and

> > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > >

> > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

year ago

> > > and after having a bad experience with methotrexate (which is

known to

> > > cause lung disease although others on this board have gotten

along ok

> > > w/it) I was afraid to take Plaquenil. The stiffness and pain

finally

> > > drove me to start it 4 nights ago at just 50 mgs once in the

evening.

> > > It's normally prescribed at 200 mgs twice a day. I'm nervous

because I

> > > have a long history of unpleasant drug side effects.

> > >

> > > While consulting w/my pulmo recently I thought she said

something about

> > > the Plaquenil helping (as in making better) one of my allergic

> > > complaints so I assume that the anti-inflammatory properties

of

> > > Plaquenil must reduce the allergic inflammation also?

> > >

> > > Again, has anyone tried Plaquenil who has severe allergies (My

IgE was

> > > 409 before Xolair and on Xolair over 1200)???? I've been

having a

> > > rather bad time for several weeks - can hear myself wheezing

softly

> > > (actually thought it was the cat purring until I held my

breath and

> > > noticed the cat " stopped " purring!!!) and even my hubby can

hear it.

> > > So, the current treatments are not really enough to keep the

allergies

> > > truly under control right now.

> > >

> > > I guess that theoretically the dose is so low on Plaquenil

that it

> > > shouldn't have any effect although I think it is causing

nightmarish

> > > disturbing dreams. I thought I was a bit more irritable too

plus there

> > > was decreasing nausea the first 3 nights. On the other hand,

I'm

> > > hoping I'll be able to work up gradually to the normal dose.

It would

> > > be good to control two different diseases (although several

docs have

> > > told me that arthritis, allergies, and asthma are all related)

at the

> > > same time.

> > >

> > > It's doubtful that any influence on Xolair or vice versa is

known since

> > > Xolair is so new and it works on different systems (I assume)

and in a

> > > completely different way.

> > >

> > > Plaquenil comments, anyone?

> > > Thx

> > >

> >

> >

> >

>

[Guest guest]

Thanks for the reply. Does this mean that the IgE levels continue to increase

or do they decrease after you have been on the xolair for a while? In my

daughter;s case she is very allergic to the environment outdoors and in and she

is extremely itchy 24/7. I guess I was hoping that the xolair would lower her

IgE and this in turn would help with the hives, itcing, etc. She also has

allergic asthma but that isn't as bad as in the past(it seems when her AD is bad

her asthma is better). I know I am looking for a miracle here. At one point

her allergist had suggested she try xolair but now he is waiting until she sees

this new dr in June which is only 2 1/2 weeks away so I can ask him these

questions. I just figured you guys have personal experience and probably know

more than drs anyway. I do appreciate any info you have or anyone with allergic

eczema with high IgE levels that xolair has helped. Thank you. jean

---- heather <heaven1975@...> wrote:

>

> as best as i understand it, the IgE level appears to increase

> because its measuring the amount of " bound IgE " (the part that

> xolair already worked on) as well as the new " free floating IgE "

> (the part that your body made since your last dose of xolair). your

> body continues to make new IgE. xolair does its best to keep up

> with it.

>

> you can see this post

> /message/6289 for a

> better explanation. also, you might want to do a message search

> for " free floating IgE " for more information about it.

>

> heather

>

>

> > > >

> > > > Ok, I'm back at it again with arthritis meds along with my

> Xolair and

> > > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > > >

> > > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

> year ago

> > > > and after having a bad experience with methotrexate (which is

> known to

> > > > cause lung disease although others on this board have gotten

> along ok

> > > > w/it) I was afraid to take Plaquenil. The stiffness and pain

> finally

> > > > drove me to start it 4 nights ago at just 50 mgs once in the

> evening.

> > > > It's normally prescribed at 200 mgs twice a day. I'm nervous

> because I

> > > > have a long history of unpleasant drug side effects.

> > > >

> > > > While consulting w/my pulmo recently I thought she said

> something about

> > > > the Plaquenil helping (as in making better) one of my allergic

> > > > complaints so I assume that the anti-inflammatory properties

> of

> > > > Plaquenil must reduce the allergic inflammation also?

> > > >

> > > > Again, has anyone tried Plaquenil who has severe allergies (My

> IgE was

> > > > 409 before Xolair and on Xolair over 1200)???? I've been

> having a

> > > > rather bad time for several weeks - can hear myself wheezing

> softly

> > > > (actually thought it was the cat purring until I held my

> breath and

> > > > noticed the cat " stopped " purring!!!) and even my hubby can

> hear it.

> > > > So, the current treatments are not really enough to keep the

> allergies

> > > > truly under control right now.

> > > >

> > > > I guess that theoretically the dose is so low on Plaquenil

> that it

> > > > shouldn't have any effect although I think it is causing

> nightmarish

> > > > disturbing dreams. I thought I was a bit more irritable too

> plus there

> > > > was decreasing nausea the first 3 nights. On the other hand,

> I'm

> > > > hoping I'll be able to work up gradually to the normal dose.

> It would

> > > > be good to control two different diseases (although several

> docs have

> > > > told me that arthritis, allergies, and asthma are all related)

> at the

> > > > same time.

> > > >

> > > > It's doubtful that any influence on Xolair or vice versa is

> known since

> > > > Xolair is so new and it works on different systems (I assume)

> and in a

> > > > completely different way.

> > > >

> > > > Plaquenil comments, anyone?

> > > > Thx

> > > >

> > >

> > >

> > >

> >

>

>

[Guest guest]

thank you for the reply. I understand now from s post. I can't believe

the person whos IgE is 45,000/ I feel so bad for them. jean

---- K K <grneyyedlady@...> wrote:

> yup! 's got that right!

>

> The " average blood test " that checks one's IgE level can not differentiate

between the bound and un bound IgE. So if someone is on Xolair and they get

their IgE levels checked it looks like there levels have trippled -+. There are

quite a few people that my allergists treats who have their " normal " IgE levels

in the 6,000 range. Think there is also some one in here who's level was like

45,000 ( yup....read that right!)

>

>

>

>

>

> From: heather <heaven1975@...>

> Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

>

> Date: Thursday, May 22, 2008, 2:43 PM

>

>

>

>

>

>

>

> as best as i understand it, the IgE level appears to increase

> because its measuring the amount of " bound IgE " (the part that

> xolair already worked on) as well as the new " free floating IgE "

> (the part that your body made since your last dose of xolair). your

> body continues to make new IgE. xolair does its best to keep up

> with it.

>

> you can see this post

> http://health. groups.. com/group/ / message/6289 for a

> better explanation. also, you might want to do a message search

> for " free floating IgE " for more information about it.

>

> heather

>

>

> > > >

> > > > Ok, I'm back at it again with arthritis meds along with my

> Xolair and

> > > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > > >

> > > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

> year ago

> > > > and after having a bad experience with methotrexate (which is

> known to

> > > > cause lung disease although others on this board have gotten

> along ok

> > > > w/it) I was afraid to take Plaquenil. The stiffness and pain

> finally

> > > > drove me to start it 4 nights ago at just 50 mgs once in the

> evening.

> > > > It's normally prescribed at 200 mgs twice a day. I'm nervous

> because I

> > > > have a long history of unpleasant drug side effects.

> > > >

> > > > While consulting w/my pulmo recently I thought she said

> something about

> > > > the Plaquenil helping (as in making better) one of my allergic

> > > > complaints so I assume that the anti-inflammatory properties

> of

> > > > Plaquenil must reduce the allergic inflammation also?

> > > >

> > > > Again, has anyone tried Plaquenil who has severe allergies (My

> IgE was

> > > > 409 before Xolair and on Xolair over 1200)???? I've been

> having a

> > > > rather bad time for several weeks - can hear myself wheezing

> softly

> > > > (actually thought it was the cat purring until I held my

> breath and

> > > > noticed the cat " stopped " purring!!!) and even my hubby can

> hear it.

> > > > So, the current treatments are not really enough to keep the

> allergies

> > > > truly under control right now.

> > > >

> > > > I guess that theoretically the dose is so low on Plaquenil

> that it

> > > > shouldn't have any effect although I think it is causing

> nightmarish

> > > > disturbing dreams. I thought I was a bit more irritable too

> plus there

> > > > was decreasing nausea the first 3 nights. On the other hand,

> I'm

> > > > hoping I'll be able to work up gradually to the normal dose.

> It would

> > > > be good to control two different diseases (although several

> docs have

> > > > told me that arthritis, allergies, and asthma are all related)

> at the

> > > > same time.

> > > >

> > > > It's doubtful that any influence on Xolair or vice versa is

> known since

> > > > Xolair is so new and it works on different systems (I assume)

> and in a

> > > > completely different way.

> > > >

> > > > Plaquenil comments, anyone?

> > > > Thx

> > > >

> > >

> > >

> > >

> >

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

How about this one, guys. After a year on Xolair, my free IgE tested at 1900

(the test differentiates between bound, free and tissue bound IgE). Before I

started on Xolair, my IgE was 900, and of course that was free IgE because I

hadn't started Xolair yet. Doc is puzzled by this, but says if the Xolair is

working, forget the IgE figures. However, I've got other issues involved -

inflamed and infected sinuses off and on, so I don't know whether the Xolair is

working or not. My wheezing at night is better, but I still seem to have lung

congestion. My new infectious disease doc did a soup Nazi routine and shouted

" No more antibiotics for you " when he learned I'd had more than 30 antibiotic

prescriptions in the last year and a half. He wants to get rid of the

inflammation first, and if I still have infections after that, he'll have them

sucked out. Sounds weird to me, but everything else has failed.

Ohldepharte

----- Original Message -----

From: K K

Sent: Thursday, May 22, 2008 2:51 PM

Subject: Re: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

yup! 's got that right!

The " average blood test " that checks one's IgE level can not differentiate

between the bound and un bound IgE. So if someone is on Xolair and they get

their IgE levels checked it looks like there levels have trippled -+. There are

quite a few people that my allergists treats who have their " normal " IgE levels

in the 6,000 range. Think there is also some one in here who's level was like

45,000 ( yup....read that right!)

From: heather <heaven1975@...>

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

Date: Thursday, May 22, 2008, 2:43 PM

as best as i understand it, the IgE level appears to increase

because its measuring the amount of " bound IgE " (the part that

xolair already worked on) as well as the new " free floating IgE "

(the part that your body made since your last dose of xolair). your

body continues to make new IgE. xolair does its best to keep up

with it.

you can see this post

http://health. groups.. com/group/ / message/6289 for a

better explanation. also, you might want to do a message search

for " free floating IgE " for more information about it.

heather

> > >

> > > Ok, I'm back at it again with arthritis meds along with my

Xolair and

> > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > >

> > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

year ago

> > > and after having a bad experience with methotrexate (which is

known to

> > > cause lung disease although others on this board have gotten

along ok

> > > w/it) I was afraid to take Plaquenil. The stiffness and pain

finally

> > > drove me to start it 4 nights ago at just 50 mgs once in the

evening.

> > > It's normally prescribed at 200 mgs twice a day. I'm nervous

because I

> > > have a long history of unpleasant drug side effects.

> > >

> > > While consulting w/my pulmo recently I thought she said

something about

> > > the Plaquenil helping (as in making better) one of my allergic

> > > complaints so I assume that the anti-inflammatory properties

of

> > > Plaquenil must reduce the allergic inflammation also?

> > >

> > > Again, has anyone tried Plaquenil who has severe allergies (My

IgE was

> > > 409 before Xolair and on Xolair over 1200)???? I've been

having a

> > > rather bad time for several weeks - can hear myself wheezing

softly

> > > (actually thought it was the cat purring until I held my

breath and

> > > noticed the cat " stopped " purring!!!) and even my hubby can

hear it.

> > > So, the current treatments are not really enough to keep the

allergies

> > > truly under control right now.

> > >

> > > I guess that theoretically the dose is so low on Plaquenil

that it

> > > shouldn't have any effect although I think it is causing

nightmarish

> > > disturbing dreams. I thought I was a bit more irritable too

plus there

> > > was decreasing nausea the first 3 nights. On the other hand,

I'm

> > > hoping I'll be able to work up gradually to the normal dose.

It would

> > > be good to control two different diseases (although several

docs have

> > > told me that arthritis, allergies, and asthma are all related)

at the

> > > same time.

> > >

> > > It's doubtful that any influence on Xolair or vice versa is

known since

> > > Xolair is so new and it works on different systems (I assume)

and in a

> > > completely different way.

> > >

> > > Plaquenil comments, anyone?

> > > Thx

> > >

> >

> >

> >

>

[Guest guest]

You are a lot like me. Not all symptoms correlate to immediate hypersensitivity

(ie. driven

by IgE). I have Eosinophilic Esophagitis, Asthma as well as GERD. The GERD gets

into both

my already inflamed esophagus and my lungs, the latter which is driven by

non-IgE

sensitivity. Because of the GERD I am prone to infections in both my lungs and

esophagus.

Xolair can do nothing for that. Xolair controls the allergic component of my

asthma, but

sadly for me does little for my EE. The current medical opinion is that despite

Asthma and

EE being related, EE is more likely driven by T-cells.

> > > >

> > > > Ok, I'm back at it again with arthritis meds along with my

> Xolair and

> > > > associated asthma meds - Advair (500/50), Spiriva, Albuterol.

> > > >

> > > > I was diagnosed w/Serro negative rheumatoid arthritis almost a

> year ago

> > > > and after having a bad experience with methotrexate (which is

> known to

> > > > cause lung disease although others on this board have gotten

> along ok

> > > > w/it) I was afraid to take Plaquenil. The stiffness and pain

> finally

> > > > drove me to start it 4 nights ago at just 50 mgs once in the

> evening.

> > > > It's normally prescribed at 200 mgs twice a day. I'm nervous

> because I

> > > > have a long history of unpleasant drug side effects.

> > > >

> > > > While consulting w/my pulmo recently I thought she said

> something about

> > > > the Plaquenil helping (as in making better) one of my allergic

> > > > complaints so I assume that the anti-inflammatory properties

> of

> > > > Plaquenil must reduce the allergic inflammation also?

> > > >

> > > > Again, has anyone tried Plaquenil who has severe allergies (My

> IgE was

> > > > 409 before Xolair and on Xolair over 1200)???? I've been

> having a

> > > > rather bad time for several weeks - can hear myself wheezing

> softly

> > > > (actually thought it was the cat purring until I held my

> breath and

> > > > noticed the cat " stopped " purring!!!) and even my hubby can

> hear it.

> > > > So, the current treatments are not really enough to keep the

> allergies

> > > > truly under control right now.

> > > >

> > > > I guess that theoretically the dose is so low on Plaquenil

> that it

> > > > shouldn't have any effect although I think it is causing

> nightmarish

> > > > disturbing dreams. I thought I was a bit more irritable too

> plus there

> > > > was decreasing nausea the first 3 nights. On the other hand,

> I'm

> > > > hoping I'll be able to work up gradually to the normal dose.

> It would

> > > > be good to control two different diseases (although several

> docs have

> > > > told me that arthritis, allergies, and asthma are all related)

> at the

> > > > same time.

> > > >

> > > > It's doubtful that any influence on Xolair or vice versa is

> known since

> > > > Xolair is so new and it works on different systems (I assume)

> and in a

> > > > completely different way.

> > > >

> > > > Plaquenil comments, anyone?

> > > > Thx

> > > >

> > >

> > >

> > >

> >

>

>

>

>

>

>

[Guest guest]

CLARIFICATION - we are all making new IgE all the time, so we can

experience allergic reactions from any new IgE that gets a chance to

bind to the mast cell prior to Xolair getting to it.

Xolair does not ADD IgE. It binds to the IgE so it will not bind to

the mast cell and start the allergic chain. The bound IgE stays in

our system and most of the tests our docs have access to cannot

distinguish between bound IgE and unbound IgE, so results of IgE

tests while people are taking Xolair (and for 6 months are so after)

are somewhat inflated.

Terry, your ID guy has a pretty good plan. If you can control your

inflammatory responses you shouldn't get an infection. You and I

are very much in the same boat as far as that is concerned.

I hope all of you have a very healthy holiday weekend!

Addy

Group co-owner

> > > >

> > > > Ok, I'm back at it again with arthritis meds along with my

> Xolair and

> > > > associated asthma meds - Advair (500/50), Spiriva,

Albuterol.

> > > >

> > > > I was diagnosed w/Serro negative rheumatoid arthritis

almost a

> year ago

> > > > and after having a bad experience with methotrexate (which

is

> known to

> > > > cause lung disease although others on this board have

gotten

> along ok

> > > > w/it) I was afraid to take Plaquenil. The stiffness and

pain

> finally

> > > > drove me to start it 4 nights ago at just 50 mgs once in

the

> evening.

> > > > It's normally prescribed at 200 mgs twice a day. I'm

nervous

> because I

> > > > have a long history of unpleasant drug side effects.

> > > >

> > > > While consulting w/my pulmo recently I thought she said

> something about

> > > > the Plaquenil helping (as in making better) one of my

allergic

> > > > complaints so I assume that the anti-inflammatory

properties

> of

> > > > Plaquenil must reduce the allergic inflammation also?

> > > >

> > > > Again, has anyone tried Plaquenil who has severe allergies

(My

> IgE was

> > > > 409 before Xolair and on Xolair over 1200)???? I've been

> having a

> > > > rather bad time for several weeks - can hear myself

wheezing

> softly

> > > > (actually thought it was the cat purring until I held my

> breath and

> > > > noticed the cat " stopped " purring!!!) and even my hubby can

> hear it.

> > > > So, the current treatments are not really enough to keep

the

> allergies

> > > > truly under control right now.

> > > >

> > > > I guess that theoretically the dose is so low on Plaquenil

> that it

> > > > shouldn't have any effect although I think it is causing

> nightmarish

> > > > disturbing dreams. I thought I was a bit more irritable too

> plus there

> > > > was decreasing nausea the first 3 nights. On the other

hand,

> I'm

> > > > hoping I'll be able to work up gradually to the normal

dose.

> It would

> > > > be good to control two different diseases (although several

> docs have

> > > > told me that arthritis, allergies, and asthma are all

related)

> at the

> > > > same time.

> > > >

> > > > It's doubtful that any influence on Xolair or vice versa is

> known since

> > > > Xolair is so new and it works on different systems (I

assume)

> and in a

> > > > completely different way.

> > > >

> > > > Plaquenil comments, anyone?

> > > > Thx

> > > >

> > >

> > >

> > >

> >

>

>

>

>

>

>

[Guest guest]

I am curious. & nbsp; How does the GERD cause your lungs to become infected? & nbsp;

Do you also have a hiatal hernia? & nbsp; Can you not take med for the GERD which

would help control the acidity? & nbsp; It is my understanding (I am not a

pharmacist, nor a medical specialist, but I do read a lot) that Nexium helps

heal the esophagus from the GERD, but I guess it doesn't help your EE? & nbsp; I

do know that GERD, if not treated can lead to esophageal cancer. & nbsp; I have a

friend who has had GERD, did not know it so it was not treated, and he has had

surgery for esophageal cancer, which the doctors told him was from the untreated

GERD. & nbsp; Of course he now takes meds for the GERD. & nbsp; Sounds like you have

some very serious problems. & nbsp;

& nbsp;

My allergist has insisted that I have an endoscopy to make sure there is no

esophageal damage so far. & nbsp; My GP who dislikes tests overall, agreed that I

should have this done. & nbsp; So I have one scheduled.

& nbsp;

The xolair has cut down on my sinus/respiratory infections, mainly because mine

were caused by allergies--sneezing, drainage, etc. & nbsp; Of course any infection

always led to a severe asthma attack and prednisone. & nbsp; Haven't had to go the

antibiotic/prednisone route since I have been on xolair! & nbsp; Yea!

& nbsp;

I have known since my asthma became mildly severe that GERD (acid reflux) and

asthma somehow always go together, but not being a medical specialist, I have

always wondered why, or how. & nbsp;

& nbsp;

It is hot, humid and the mold count is way up here in SA. & nbsp; I don't go

outside anymore than I have to....it is hard to breathe when the weather is hot

and humid! & nbsp; I am so thankful for A/C.

& nbsp;

Remembering our brave, loyal, courageous soldiers this Memorial Day--both living

and those who have given their lives for our freedom.....let us never forget

them.......

& nbsp;

Adah

From: billybaroo1958 & lt;cajjz109@... & gt;

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

Date: Friday, May 23, 2008, 3:02 AM

You are a lot like me. Not all symptoms correlate to immediate hypersensitivity

(ie. driven

by IgE). I have Eosinophilic Esophagitis, Asthma as well as GERD. The GERD gets

into both

my already inflamed esophagus and my lungs, the latter which is driven by

non-IgE

sensitivity. Because of the GERD I am prone to infections in both my lungs and

esophagus.

Xolair can do nothing for that. Xolair controls the allergic component of my

asthma, but

sadly for me does little for my EE. The current medical opinion is that despite

Asthma and

EE being related, EE is more likely driven by T-cells.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; Ok, I'm back at it again with arthritis meds along with my

& gt; Xolair and

& gt; & gt; & gt; & gt; associated asthma meds - Advair (500/50), Spiriva,

Albuterol.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; I was diagnosed w/Serro negative rheumatoid arthritis almost

a

& gt; year ago

& gt; & gt; & gt; & gt; and after having a bad experience with methotrexate (which

is

& gt; known to

& gt; & gt; & gt; & gt; cause lung disease although others on this board have gotten

& gt; along ok

& gt; & gt; & gt; & gt; w/it) I was afraid to take Plaquenil. The stiffness and pain

& gt; finally

& gt; & gt; & gt; & gt; drove me to start it 4 nights ago at just 50 mgs once in the

& gt; evening.

& gt; & gt; & gt; & gt; It's normally prescribed at 200 mgs twice a day. I'm nervous

& gt; because I

& gt; & gt; & gt; & gt; have a long history of unpleasant drug side effects.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; While consulting w/my pulmo recently I thought she said

& gt; something about

& gt; & gt; & gt; & gt; the Plaquenil helping (as in making better) one of my

allergic

& gt; & gt; & gt; & gt; complaints so I assume that the anti-inflammatory properties

& gt; of

& gt; & gt; & gt; & gt; Plaquenil must reduce the allergic inflammation also?

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; Again, has anyone tried Plaquenil who has severe allergies

(My

& gt; IgE was

& gt; & gt; & gt; & gt; 409 before Xolair and on Xolair over 1200)???? I've been

& gt; having a

& gt; & gt; & gt; & gt; rather bad time for several weeks - can hear myself wheezing

& gt; softly

& gt; & gt; & gt; & gt; (actually thought it was the cat purring until I held my

& gt; breath and

& gt; & gt; & gt; & gt; noticed the cat " stopped " purring!!!) and even my hubby can

& gt; hear it.

& gt; & gt; & gt; & gt; So, the current treatments are not really enough to keep the

& gt; allergies

& gt; & gt; & gt; & gt; truly under control right now.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; I guess that theoretically the dose is so low on Plaquenil

& gt; that it

& gt; & gt; & gt; & gt; shouldn't have any effect although I think it is causing

& gt; nightmarish

& gt; & gt; & gt; & gt; disturbing dreams. I thought I was a bit more irritable too

& gt; plus there

& gt; & gt; & gt; & gt; was decreasing nausea the first 3 nights. On the other hand,

& gt; I'm

& gt; & gt; & gt; & gt; hoping I'll be able to work up gradually to the normal dose.

& gt; It would

& gt; & gt; & gt; & gt; be good to control two different diseases (although several

& gt; docs have

& gt; & gt; & gt; & gt; told me that arthritis, allergies, and asthma are all

related)

& gt; at the

& gt; & gt; & gt; & gt; same time.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; It's doubtful that any influence on Xolair or vice versa is

& gt; known since

& gt; & gt; & gt; & gt; Xolair is so new and it works on different systems (I

assume)

& gt; and in a

& gt; & gt; & gt; & gt; completely different way.

& gt; & gt; & gt; & gt;

& gt; & gt; & gt; & gt; Plaquenil comments, anyone?

& gt; & gt; & gt; & gt; Thx

& gt; & gt; & gt; & gt;

& gt; & gt; & gt;

& gt; & gt; & gt;

& gt; & gt; & gt;

& gt; & gt;

& gt;

& gt;

& gt;

& gt;

& gt;

& gt;

[Guest guest]

Hi Addy and the rest of the group. I have learn a lot from this group and Your

help is greatly appreciated. You have a healthy and happy weekend as well.

Jean

---- pyle456 <coachmac@...> wrote:

> CLARIFICATION - we are all making new IgE all the time, so we can

> experience allergic reactions from any new IgE that gets a chance to

> bind to the mast cell prior to Xolair getting to it.

>

> Xolair does not ADD IgE. It binds to the IgE so it will not bind to

> the mast cell and start the allergic chain. The bound IgE stays in

> our system and most of the tests our docs have access to cannot

> distinguish between bound IgE and unbound IgE, so results of IgE

> tests while people are taking Xolair (and for 6 months are so after)

> are somewhat inflated.

>

> Terry, your ID guy has a pretty good plan. If you can control your

> inflammatory responses you shouldn't get an infection. You and I

> are very much in the same boat as far as that is concerned.

>

> I hope all of you have a very healthy holiday weekend!

>

> Addy

> Group co-owner

>

>

>

>

>

> > > > >

> > > > > Ok, I'm back at it again with arthritis meds along with my

> > Xolair and

> > > > > associated asthma meds - Advair (500/50), Spiriva,

> Albuterol.

> > > > >

> > > > > I was diagnosed w/Serro negative rheumatoid arthritis

> almost a

> > year ago

> > > > > and after having a bad experience with methotrexate (which

> is

> > known to

> > > > > cause lung disease although others on this board have

> gotten

> > along ok

> > > > > w/it) I was afraid to take Plaquenil. The stiffness and

> pain

> > finally

> > > > > drove me to start it 4 nights ago at just 50 mgs once in

> the

> > evening.

> > > > > It's normally prescribed at 200 mgs twice a day. I'm

> nervous

> > because I

> > > > > have a long history of unpleasant drug side effects.

> > > > >

> > > > > While consulting w/my pulmo recently I thought she said

> > something about

> > > > > the Plaquenil helping (as in making better) one of my

> allergic

> > > > > complaints so I assume that the anti-inflammatory

> properties

> > of

> > > > > Plaquenil must reduce the allergic inflammation also?

> > > > >

> > > > > Again, has anyone tried Plaquenil who has severe allergies

> (My

> > IgE was

> > > > > 409 before Xolair and on Xolair over 1200)???? I've been

> > having a

> > > > > rather bad time for several weeks - can hear myself

> wheezing

> > softly

> > > > > (actually thought it was the cat purring until I held my

> > breath and

> > > > > noticed the cat " stopped " purring!!!) and even my hubby can

> > hear it.

> > > > > So, the current treatments are not really enough to keep

> the

> > allergies

> > > > > truly under control right now.

> > > > >

> > > > > I guess that theoretically the dose is so low on Plaquenil

> > that it

> > > > > shouldn't have any effect although I think it is causing

> > nightmarish

> > > > > disturbing dreams. I thought I was a bit more irritable too

> > plus there

> > > > > was decreasing nausea the first 3 nights. On the other

> hand,

> > I'm

> > > > > hoping I'll be able to work up gradually to the normal

> dose.

> > It would

> > > > > be good to control two different diseases (although several

> > docs have

> > > > > told me that arthritis, allergies, and asthma are all

> related)

> > at the

> > > > > same time.

> > > > >

> > > > > It's doubtful that any influence on Xolair or vice versa is

> > known since

> > > > > Xolair is so new and it works on different systems (I

> assume)

> > and in a

> > > > > completely different way.

> > > > >

> > > > > Plaquenil comments, anyone?

> > > > > Thx

> > > > >

> > > >

> > > >

> > > >

> > >

> >

> >

> >

> >

> >

> >

[Guest guest]

It has almost nothing to do with acid per se. Refluxate from the

stomach that is aspirated into the lungs and esophagus, of which mine

are idiopathically filled with eosinophils, makes them hypersensitive

to bacteria. Same theory behind why asthmatics are susceptible to

bronchitis from colds and flus. The virus or bacteria can lodge and

infect in the already inflamed areas, and further the eosinophils then

can highten the process. But, I don't have simple GERD. I have

Eosinophilic Esophagitis and it is not easy to control.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; Ok, I'm back at it again with arthritis meds

along with my

> & gt; Xolair and

> & gt; & gt; & gt; & gt; associated asthma meds - Advair (500/50),

Spiriva, Albuterol.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; I was diagnosed w/Serro negative rheumatoid

arthritis almost a

> & gt; year ago

> & gt; & gt; & gt; & gt; and after having a bad experience with

methotrexate (which is

> & gt; known to

> & gt; & gt; & gt; & gt; cause lung disease although others on this board

have gotten

> & gt; along ok

> & gt; & gt; & gt; & gt; w/it) I was afraid to take Plaquenil. The

stiffness and pain

> & gt; finally

> & gt; & gt; & gt; & gt; drove me to start it 4 nights ago at just 50 mgs

once in the

> & gt; evening.

> & gt; & gt; & gt; & gt; It's normally prescribed at 200 mgs twice a day.

I'm nervous

> & gt; because I

> & gt; & gt; & gt; & gt; have a long history of unpleasant drug side

effects.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; While consulting w/my pulmo recently I thought

she said

> & gt; something about

> & gt; & gt; & gt; & gt; the Plaquenil helping (as in making better) one

of my allergic

> & gt; & gt; & gt; & gt; complaints so I assume that the

anti-inflammatory properties

> & gt; of

> & gt; & gt; & gt; & gt; Plaquenil must reduce the allergic inflammation

also?

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; Again, has anyone tried Plaquenil who has severe

allergies (My

> & gt; IgE was

> & gt; & gt; & gt; & gt; 409 before Xolair and on Xolair over 1200)????

I've been

> & gt; having a

> & gt; & gt; & gt; & gt; rather bad time for several weeks - can hear

myself wheezing

> & gt; softly

> & gt; & gt; & gt; & gt; (actually thought it was the cat purring until I

held my

> & gt; breath and

> & gt; & gt; & gt; & gt; noticed the cat " stopped " purring!!!) and even

my hubby can

> & gt; hear it.

> & gt; & gt; & gt; & gt; So, the current treatments are not really enough

to keep the

> & gt; allergies

> & gt; & gt; & gt; & gt; truly under control right now.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; I guess that theoretically the dose is so low on

Plaquenil

> & gt; that it

> & gt; & gt; & gt; & gt; shouldn't have any effect although I think it is

causing

> & gt; nightmarish

> & gt; & gt; & gt; & gt; disturbing dreams. I thought I was a bit more

irritable too

> & gt; plus there

> & gt; & gt; & gt; & gt; was decreasing nausea the first 3 nights. On the

other hand,

> & gt; I'm

> & gt; & gt; & gt; & gt; hoping I'll be able to work up gradually to the

normal dose.

> & gt; It would

> & gt; & gt; & gt; & gt; be good to control two different diseases

(although several

> & gt; docs have

> & gt; & gt; & gt; & gt; told me that arthritis, allergies, and asthma

are all related)

> & gt; at the

> & gt; & gt; & gt; & gt; same time.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; It's doubtful that any influence on Xolair or

vice versa is

> & gt; known since

> & gt; & gt; & gt; & gt; Xolair is so new and it works on different

systems (I assume)

> & gt; and in a

> & gt; & gt; & gt; & gt; completely different way.

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt; & gt; Plaquenil comments, anyone?

> & gt; & gt; & gt; & gt; Thx

> & gt; & gt; & gt; & gt;

> & gt; & gt; & gt;

> & gt; & gt; & gt;

> & gt; & gt; & gt;

> & gt; & gt;

> & gt;

> & gt;

> & gt;

> & gt;

> & gt;

> & gt;

[Guest guest]

Hi Addy - that was my point - this special test was supposed to provide free

unbound IgE, Xolair bound IgE and tissue bound IgE readings separately, and yet

the free IgE only reading was more than double what it was before I started

Xolair. Go figure.

Terry

----- Original Message -----

From: pyle456

Sent: Friday, May 23, 2008 7:39 AM

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

CLARIFICATION - we are all making new IgE all the time, so we can

experience allergic reactions from any new IgE that gets a chance to

bind to the mast cell prior to Xolair getting to it.

Xolair does not ADD IgE. It binds to the IgE so it will not bind to

the mast cell and start the allergic chain. The bound IgE stays in

our system and most of the tests our docs have access to cannot

distinguish between bound IgE and unbound IgE, so results of IgE

tests while people are taking Xolair (and for 6 months are so after)

are somewhat inflated.

Terry, your ID guy has a pretty good plan. If you can control your

inflammatory responses you shouldn't get an infection. You and I

are very much in the same boat as far as that is concerned.

I hope all of you have a very healthy holiday weekend!

Addy

Group co-owner

> > > >

> > > > Ok, I'm back at it again with arthritis meds along with my

> Xolair and

> > > > associated asthma meds - Advair (500/50), Spiriva,

Albuterol.

> > > >

> > > > I was diagnosed w/Serro negative rheumatoid arthritis

almost a

> year ago

> > > > and after having a bad experience with methotrexate (which

is

> known to

> > > > cause lung disease although others on this board have

gotten

> along ok

> > > > w/it) I was afraid to take Plaquenil. The stiffness and

pain

> finally

> > > > drove me to start it 4 nights ago at just 50 mgs once in

the

> evening.

> > > > It's normally prescribed at 200 mgs twice a day. I'm

nervous

> because I

> > > > have a long history of unpleasant drug side effects.

> > > >

> > > > While consulting w/my pulmo recently I thought she said

> something about

> > > > the Plaquenil helping (as in making better) one of my

allergic

> > > > complaints so I assume that the anti-inflammatory

properties

> of

> > > > Plaquenil must reduce the allergic inflammation also?

> > > >

> > > > Again, has anyone tried Plaquenil who has severe allergies

(My

> IgE was

> > > > 409 before Xolair and on Xolair over 1200)???? I've been

> having a

> > > > rather bad time for several weeks - can hear myself

wheezing

> softly

> > > > (actually thought it was the cat purring until I held my

> breath and

> > > > noticed the cat " stopped " purring!!!) and even my hubby can

> hear it.

> > > > So, the current treatments are not really enough to keep

the

> allergies

> > > > truly under control right now.

> > > >

> > > > I guess that theoretically the dose is so low on Plaquenil

> that it

> > > > shouldn't have any effect although I think it is causing

> nightmarish

> > > > disturbing dreams. I thought I was a bit more irritable too

> plus there

> > > > was decreasing nausea the first 3 nights. On the other

hand,

> I'm

> > > > hoping I'll be able to work up gradually to the normal

dose.

> It would

> > > > be good to control two different diseases (although several

> docs have

> > > > told me that arthritis, allergies, and asthma are all

related)

> at the

> > > > same time.

> > > >

> > > > It's doubtful that any influence on Xolair or vice versa is

> known since

> > > > Xolair is so new and it works on different systems (I

assume)

> and in a

> > > > completely different way.

> > > >

> > > > Plaquenil comments, anyone?

> > > > Thx

> > > >

> > >

> > >

> > >

> >

>

>

>

>

>

>

[Guest guest]

Terry - did you get that test through your local doc or on one of

your trips to Duke?

FYI - my boss carries around a mug at work that says " I (heart)

myself, " so I brought my Duke alumni mug to use at work. Same

difference!

How many more days til basketball season starts?

Addy

Group co-owner

> > > > >

> > > > > Ok, I'm back at it again with arthritis meds along with

my

> > Xolair and

> > > > > associated asthma meds - Advair (500/50), Spiriva,

> Albuterol.

> > > > >

> > > > > I was diagnosed w/Serro negative rheumatoid arthritis

> almost a

> > year ago

> > > > > and after having a bad experience with methotrexate

(which

> is

> > known to

> > > > > cause lung disease although others on this board have

> gotten

> > along ok

> > > > > w/it) I was afraid to take Plaquenil. The stiffness and

> pain

> > finally

> > > > > drove me to start it 4 nights ago at just 50 mgs once in

> the

> > evening.

> > > > > It's normally prescribed at 200 mgs twice a day. I'm

> nervous

> > because I

> > > > > have a long history of unpleasant drug side effects.

> > > > >

> > > > > While consulting w/my pulmo recently I thought she said

> > something about

> > > > > the Plaquenil helping (as in making better) one of my

> allergic

> > > > > complaints so I assume that the anti-inflammatory

> properties

> > of

> > > > > Plaquenil must reduce the allergic inflammation also?

> > > > >

> > > > > Again, has anyone tried Plaquenil who has severe

allergies

> (My

> > IgE was

> > > > > 409 before Xolair and on Xolair over 1200)???? I've been

> > having a

> > > > > rather bad time for several weeks - can hear myself

> wheezing

> > softly

> > > > > (actually thought it was the cat purring until I held my

> > breath and

> > > > > noticed the cat " stopped " purring!!!) and even my hubby

can

> > hear it.

> > > > > So, the current treatments are not really enough to keep

> the

> > allergies

> > > > > truly under control right now.

> > > > >

> > > > > I guess that theoretically the dose is so low on

Plaquenil

> > that it

> > > > > shouldn't have any effect although I think it is causing

> > nightmarish

> > > > > disturbing dreams. I thought I was a bit more irritable

too

> > plus there

> > > > > was decreasing nausea the first 3 nights. On the other

> hand,

> > I'm

> > > > > hoping I'll be able to work up gradually to the normal

> dose.

> > It would

> > > > > be good to control two different diseases (although

several

> > docs have

> > > > > told me that arthritis, allergies, and asthma are all

> related)

> > at the

> > > > > same time.

> > > > >

> > > > > It's doubtful that any influence on Xolair or vice versa

is

> > known since

> > > > > Xolair is so new and it works on different systems (I

> assume)

> > and in a

> > > > > completely different way.

> > > > >

> > > > > Plaquenil comments, anyone?

> > > > > Thx

> > > > >

> > > >

> > > >

> > > >

> > >

> >

> >

> >

> >

> >

> >

[Guest guest]

Thanks for the explanation. & nbsp; I just wondered. & nbsp; Your explanation makes

sense. & nbsp; I know that I try to do all the things to keep the reflux from

happening at night--no late, hot spicy meals, raised head of the bed, two

pillows, nexium, and when I remember I take generic zantac at night. & nbsp;

From: billybaroo1958 & lt;cajjz109@... & gt;

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

Date: Friday, May 23, 2008, 9:18 PM

It has almost nothing to do with acid per se. Refluxate from the

stomach that is aspirated into the lungs and esophagus, of which mine

are idiopathically filled with eosinophils, makes them hypersensitive

to bacteria. Same theory behind why asthmatics are susceptible to

bronchitis from colds and flus. The virus or bacteria can lodge and

infect in the already inflamed areas, and further the eosinophils then

can highten the process. But, I don't have simple GERD. I have

Eosinophilic Esophagitis and it is not easy to control.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Ok, I'm back at it again with arthritis

meds

along with my

& gt; & amp;gt; Xolair and

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; associated asthma meds - Advair

(500/50),

Spiriva, Albuterol.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; I was diagnosed w/Serro negative

rheumatoid

arthritis almost a

& gt; & amp;gt; year ago

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; and after having a bad experience with

methotrexate (which is

& gt; & amp;gt; known to

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; cause lung disease although others on

this board

have gotten

& gt; & amp;gt; along ok

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; w/it) I was afraid to take Plaquenil.

The

stiffness and pain

& gt; & amp;gt; finally

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; drove me to start it 4 nights ago at

just 50 mgs

once in the

& gt; & amp;gt; evening.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; It's normally prescribed at 200 mgs

twice a day.

I'm nervous

& gt; & amp;gt; because I

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; have a long history of unpleasant drug

side

effects.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; While consulting w/my pulmo recently I

thought

she said

& gt; & amp;gt; something about

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; the Plaquenil helping (as in making

better) one

of my allergic

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; complaints so I assume that the

anti-inflammatory properties

& gt; & amp;gt; of

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Plaquenil must reduce the allergic

inflammation

also?

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Again, has anyone tried Plaquenil who

has severe

allergies (My

& gt; & amp;gt; IgE was

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; 409 before Xolair and on Xolair over

1200)????

I've been

& gt; & amp;gt; having a

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; rather bad time for several weeks - can

hear

myself wheezing

& gt; & amp;gt; softly

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; (actually thought it was the cat

purring until I

held my

& gt; & amp;gt; breath and

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; noticed the cat " stopped " purring!!!)

and even

my hubby can

& gt; & amp;gt; hear it.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; So, the current treatments are not

really enough

to keep the

& gt; & amp;gt; allergies

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; truly under control right now.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; I guess that theoretically the dose is

so low on

Plaquenil

& gt; & amp;gt; that it

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; shouldn't have any effect although I

think it is

causing

& gt; & amp;gt; nightmarish

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; disturbing dreams. I thought I was a

bit more

irritable too

& gt; & amp;gt; plus there

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; was decreasing nausea the first 3

nights. On the

other hand,

& gt; & amp;gt; I'm

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; hoping I'll be able to work up

gradually to the

normal dose.

& gt; & amp;gt; It would

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; be good to control two different

diseases

(although several

& gt; & amp;gt; docs have

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; told me that arthritis, allergies, and

asthma

are all related)

& gt; & amp;gt; at the

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; same time.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; It's doubtful that any influence on

Xolair or

vice versa is

& gt; & amp;gt; known since

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Xolair is so new and it works on

different

systems (I assume)

& gt; & amp;gt; and in a

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; completely different way.

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Plaquenil comments, anyone?

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt; Thx

& gt; & amp;gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt; & amp;gt;

& gt; & amp;gt; & amp;gt;

& gt; & amp;gt;

& gt; & amp;gt;

& gt; & amp;gt;

& gt; & amp;gt;

& gt; & amp;gt;

& gt; & amp;gt;

[Guest guest]

Addy - my local pulmo doc set up the test. Before he had me take the test (of

my blood), he claimed he was the only doc in town who had this test that would

show the various forms of IgE separately. He was perplexed by the results.

Obviously this whole Xolair thing is an inexact science with occasional

surprising results. ly, I'm beginning to think, along with my infectious

disease doc and my ENT doc, that if I can get my sinus inflammation problems

cleared up, other probs like the asthma may clear up. The infectious disease

doc says I should never use decongestants, which I'd been using regularly,

because they're contributing to the sinus drainage problem. Who knew? However,

I'm supposed to continue the Nasacort, and perhaps be put on some other really

strong steroid spray. It'll be interesting to see how this revolutionary (for

me) works out.

Terry

----- Original Message -----

From: pyle456

Sent: Saturday, May 24, 2008 6:18 AM

Subject: [ ] Re: JEAN xolair raise IgE (was Allergies, Asthma,

Arthritis....)

Terry - did you get that test through your local doc or on one of

your trips to Duke?

FYI - my boss carries around a mug at work that says " I (heart)

myself, " so I brought my Duke alumni mug to use at work. Same

difference!

How many more days til basketball season starts?

Addy

Group co-owner

> > > > >

> > > > > Ok, I'm back at it again with arthritis meds along with

my

> > Xolair and

> > > > > associated asthma meds - Advair (500/50), Spiriva,

> Albuterol.

> > > > >

> > > > > I was diagnosed w/Serro negative rheumatoid arthritis

> almost a

> > year ago

> > > > > and after having a bad experience with methotrexate

(which

> is

> > known to

> > > > > cause lung disease although others on this board have

> gotten

> > along ok

> > > > > w/it) I was afraid to take Plaquenil. The stiffness and

> pain

> > finally

> > > > > drove me to start it 4 nights ago at just 50 mgs once in

> the

> > evening.

> > > > > It's normally prescribed at 200 mgs twice a day. I'm

> nervous

> > because I

> > > > > have a long history of unpleasant drug side effects.

> > > > >

> > > > > While consulting w/my pulmo recently I thought she said

> > something about

> > > > > the Plaquenil helping (as in making better) one of my

> allergic

> > > > > complaints so I assume that the anti-inflammatory

> properties

> > of

> > > > > Plaquenil must reduce the allergic inflammation also?

> > > > >

> > > > > Again, has anyone tried Plaquenil who has severe

allergies

> (My

> > IgE was

> > > > > 409 before Xolair and on Xolair over 1200)???? I've been

> > having a

> > > > > rather bad time for several weeks - can hear myself

> wheezing

> > softly

> > > > > (actually thought it was the cat purring until I held my

> > breath and

> > > > > noticed the cat " stopped " purring!!!) and even my hubby

can

> > hear it.

> > > > > So, the current treatments are not really enough to keep

> the

> > allergies

> > > > > truly under control right now.

> > > > >

> > > > > I guess that theoretically the dose is so low on

Plaquenil

> > that it

> > > > > shouldn't have any effect although I think it is causing

> > nightmarish

> > > > > disturbing dreams. I thought I was a bit more irritable

too

> > plus there

> > > > > was decreasing nausea the first 3 nights. On the other

> hand,

> > I'm

> > > > > hoping I'll be able to work up gradually to the normal

> dose.

> > It would

> > > > > be good to control two different diseases (although

several

> > docs have

> > > > > told me that arthritis, allergies, and asthma are all

> related)

> > at the

> > > > > same time.

> > > > >

> > > > > It's doubtful that any influence on Xolair or vice versa

is

> > known since

> > > > > Xolair is so new and it works on different systems (I

> assume)

> > and in a

> > > > > completely different way.

> > > > >

> > > > > Plaquenil comments, anyone?

> > > > > Thx

> > > > >

> > > >

> > > >

> > > >

> > >

> >

> >

> >

> >

> >

> >