Re: Decreasing Effectiveness of Xolair?

[Guest guest]

Mike, not likely. I have been on for a year and one-half. My experience is that

the improvement isn't linear. Xolair binds IgE so at different moments in the

year you might produce more IgE in a given moment than Xolair can bind out.

Also, if you have had asthma for awhile, you have dealt with an inflammatory

state in that time which can get so entrenched that it will not subside over

night. While I noticed improvement in my atopy right away, I really didn't see

the inflammation (for me in my esophagus, gut, skin and lungs) become

significantly reduced for about one year. Also, meds like Singulair that barely

worked for in the past, are for more effective now. The likely reason is that

their are less eosinophils degranulating, so the Singulair can control symptoms

better now than before.

>

> Hi all,

>

> I've been on Xolair since January of this year. My first 6 weeks or so were

phenomenal. I took a case of bronchitis in mid February. Since then my peak

flows have been in the very low yellow zone with a few drops into the red. Can

Xolair start off strong and then diminish? Another oddity in my environment is

that I live about 60 miles from the volcano going off in Alaska. We have a fair

amount of 'volcanic haze' which is a mix of volcanic gasses and ash. I'm on

steroids and increased nebs. My breathing was declining before the eruptions

started, though. Thanks for the input.

>

> Mike

>

[Guest guest]

Thank you for the input.  I'd not htought about the seasonal component.  We are

just now entering 'breakup' and have a lot of dust form the sand they've used on

the roads.  Fir trees will be making bright yellow dust clouds soon.  Life moves

on.  Again, my thanks for the feed back.

 Mike McBride

Don't cry because it's over, laugh because it happened. Dr. Seuss

________________________________

From: billybaroo1958 <cajjz109@...>

Sent: Thursday, April 2, 2009 2:01:02 PM

Subject: [ ] Re: Decreasing Effectiveness of Xolair?

Mike, not likely. I have been on for a year and one-half. My experience is that

the improvement isn't linear. Xolair binds IgE so at different moments in the

year you might produce more IgE in a given moment than Xolair can bind out.

Also, if you have had asthma for awhile, you have dealt with an inflammatory

state in that time which can get so entrenched that it will not subside over

night. While I noticed improvement in my atopy right away, I really didn't see

the inflammation (for me in my esophagus, gut, skin and lungs) become

significantly reduced for about one year. Also, meds like Singulair that barely

worked for in the past, are for more effective now. The likely reason is that

their are less eosinophils degranulating, so the Singulair can control symptoms

better now than before.

>

> Hi all,

>

> I've been on Xolair since January of this year. My first 6 weeks or so were

phenomenal. I took a case of bronchitis in mid February. Since then my peak

flows have been in the very low yellow zone with a few drops into the red. Can

Xolair start off strong and then diminish? Another oddity in my environment is

that I live about 60 miles from the volcano going off in Alaska. We have a fair

amount of 'volcanic haze' which is a mix of volcanic gasses and ash. I'm on

steroids and increased nebs. My breathing was declining before the eruptions

started, though. Thanks for the input.

>

> Mike

>

[Guest guest]

UH, DUH, the volcano pollution can defintely contribute to asthma. Stay

inside, wear a mask when outdoors, and I hope you have at least one good

charcoal/hepa room filter to use in your bedroom. Best of luck to you in those

bad circumstances.

Leigh

________________________________

From: Mike <mike.dmcbride@...>

Sent: Thursday, April 2, 2009 1:46:52 PM

Subject: [ ] Decreasing Effectiveness of Xolair?

Hi all,

I've been on Xolair since January of this year. My first 6 weeks or so were

phenomenal. I took a case of bronchitis in mid February. Since then my peak

flows have been in the very low yellow zone with a few drops into the red. Can

Xolair start off strong and then diminish? Another oddity in my environment is

that I live about 60 miles from the volcano going off in Alaska. We have a fair

amount of 'volcanic haze' which is a mix of volcanic gasses and ash. I'm on

steroids and increased nebs. My breathing was declining before the eruptions

started, though. Thanks for the input.

Mike

[Guest guest]

Face maks just like the doctor ordered, windows taped/sealed, steroids being

taken, lots of movies ready to watch.  My bad....no filter yet.  Good reminder

though.

 Mike McBride

Don't cry because it's over, laugh because it happened. Dr. Seuss

________________________________

From: Leigh McCall-Alton <mccallalton@...>

Sent: Thursday, April 2, 2009 6:04:06 PM

Subject: Re: [ ] Decreasing Effectiveness of Xolair?

UH, DUH, the volcano pollution can defintely contribute to asthma. Stay inside,

wear a mask when outdoors, and I hope you have at least one good charcoal/hepa

room filter to use in your bedroom. Best of luck to you in those bad

circumstances.

Leigh

____________ _________ _________ __

From: Mike <mike.dmcbride>

Sent: Thursday, April 2, 2009 1:46:52 PM

Subject: [ ] Decreasing Effectiveness of Xolair?

Hi all,

I've been on Xolair since January of this year. My first 6 weeks or so were

phenomenal. I took a case of bronchitis in mid February. Since then my peak

flows have been in the very low yellow zone with a few drops into the red. Can

Xolair start off strong and then diminish? Another oddity in my environment is

that I live about 60 miles from the volcano going off in Alaska. We have a fair

amount of 'volcanic haze' which is a mix of volcanic gasses and ash. I'm on

steroids and increased nebs. My breathing was declining before the eruptions

started, though. Thanks for the input.

Mike

[Guest guest]

I haven't read everyone else's responses yet, but most of your trouble is

probably the smoke and ash, which Xolair will not protect you from. That's

particulate matter that is not IgE mediated.

That said, I do very well on Xolair except with the spring pollen, which is just

so overwhelming here that it finds a way to any IgE I have that has not been

bound to Xolair, so I'm having a lot of trouble with my asthma each spring. It

beats the near daily, year-round trouble I had prior to Xolair, but it is still

a bummer.

Good luck, keep your mask on!

Addy

Groupo co-owner

>

> Hi all,

>

> I've been on Xolair since January of this year. My first 6 weeks or so were

phenomenal. I took a case of bronchitis in mid February. Since then my peak

flows have been in the very low yellow zone with a few drops into the red. Can

Xolair start off strong and then diminish? Another oddity in my environment is

that I live about 60 miles from the volcano going off in Alaska. We have a fair

amount of 'volcanic haze' which is a mix of volcanic gasses and ash. I'm on

steroids and increased nebs. My breathing was declining before the eruptions

started, though. Thanks for the input.

>

> Mike

>