Guest guest Posted April 9, 2009 Report Share Posted April 9, 2009 Yes, your TOTAL IgE increases over the course of a year, before it decreases. This is because Xolair is an IgG molecule that binds (in several different configurations) to IgE that in essence will not allow IgE to do what it normally does. Because of this binding, the clearance of the IgG-IgE complex is slowed down, and your TOTAL IgE will increase. However, Your FREE IgE will decrease, leading to part of the benefit of Xolair. Most assays that test for IgE only test for TOTAL IgE, not FREE IgE. There is nothing dangerous about this, safety of Xolair in general is, safe, what is happening is normal and expected. > > does your IgE increase when you first start receiving xolair? If you Ige is already off the charts wouldn't this be dangerous? It is something I read on a few web sites and it concerns me. thanks. jean > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2009 Report Share Posted April 9, 2009 > > does your IgE increase when you first start receiving xolair? If you Ige is already off the charts wouldn't this be dangerous? It is something I read on a few web sites and it concerns me. thanks. jean > The Total IgE value will go up, but when on Xolair, the test is pretty useless anyway as what is being counted isn't " effective " IgE. Xolair forms complexes with IgE that renders it unable to do it's bad stuff, these complexes take longer to clear, therefore increasing the IgE number. I've heard of patients with serum IgE values of 200 going up past 1000 when on treatment, but with no adverse effects. I started Xolair for my Cholinergic Urticaria today - fingers crossed it does me some good! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2009 Report Share Posted April 9, 2009 Thank you . My daughter's IgE is already 5,981 and she is very atopic(mostly her skin) so I was concerned her symptoms would increase. I do feel better now. I'll keep yo in my thoughts and my fingers crossed . Let me know how you are doing. Jean > > The Total IgE value will go up, but when on Xolair, the test is pretty useless anyway as what is being counted isn't " effective " IgE. Xolair forms complexes with IgE that renders it unable to do it's bad stuff, these complexes take longer to clear, therefore increasing the IgE number. I've heard of patients with serum IgE values of 200 going up past 1000 when on treatment, but with no adverse effects. > > I started Xolair for my Cholinergic Urticaria today - fingers crossed it does me some good! > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2009 Report Share Posted April 9, 2009 Thank you. I just responded to s post and you both make me feel better about the xolair. we just got back from the drs. and she has another sinus infection and brochitis and her asthma has flared. I guess this confirms it is time to start xolair. jean > > Yes, your TOTAL IgE increases over the course of a year, before it decreases. This is because Xolair is an IgG molecule that binds (in several different configurations) to IgE that in essence will not allow IgE to do what it normally does. > > Because of this binding, the clearance of the IgG-IgE complex is slowed down, and your TOTAL IgE will increase. However, Your FREE IgE will decrease, leading to part of the benefit of Xolair. Most assays that test for IgE only test for TOTAL IgE, not FREE IgE. > > There is nothing dangerous about this, safety of Xolair in general is, safe, what is happening is normal and expected. > > > > > > does your IgE increase when you first start receiving xolair? If you Ige is already off the charts wouldn't this be dangerous? It is something I read on a few web sites and it concerns me. thanks. jean > > > Quote Link to comment Share on other sites More sharing options...
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