Re: From Pat, our xolair nurse

[Guest guest]

The joint pain that I have experienced lately has been just plain old arthritis

and I control it with over the counter Tylenol, mostly store brand. I will have

to take a break from the Xolair until I can change insurance at the beginning of

next year. I am now having the withdrawal from Xolair. By withdrawal I mean

that my allergies are out of control. Before Xolair, I was taking hydroxizine

for itching and now that I am not taking Xolair the itching is returning. I

have some Hydroxizine left over so I will be back on it. I am looking forward

to getting the next 9 months behind me so I can go back to BCBS and away from

Cigna Plus. I am having problems having all my meds refilled. The Cigna Plus

has a high deductible so I will not be able to pay for the Xolair. We have an

HRA account but it only covers $1000 and that will have to be used for blood

pressure meds and antidepressants.

----- Original Message -----

From: Db <uca79iii@...>

xolair users < >

Sent: Sun, 27 Feb 2011 21:43:04 -0000 (UTC)

Subject: [ ] From Pat, our xolair nurse

I asked her about the question of joint pain and this was her response:

" Hello all, I have seen postings about joint pain and Xolair. As head nurse for

Xolair in a Specialty Pharmacy and tracking each & every person on it, I never

heard joint pain from any one I spoke to. Repetative motion causes joint pain,

Arthritis of any kind does also. Being on prednisone and now off could be the

culprit. Most of us are heavier than the norm due to the prednisone and extra

weight causes joints to work harder. So, see your physician, have them draw

labs for arthritis, take x-rays of affected areas & formulate treatment plans.

I highly doubt there is any correlation beween Xolair & joint pain. Warm

compresses never hurt & will help the pain. Some people prefer cold compresses.

Hope this helps

Pat "

[Guest guest]

Once again thanks for the info Doug. It helps put my concern at ease for

starting my son on it.

Thanks

Sheila

Sent from my BlackBerry® smartphone

-----Original Message-----

From: " Db " <uca79iii@...>

Sender:

Date: Sun, 27 Feb 2011 21:43:04

< >

Reply-

Subject: [ ] From Pat, our xolair nurse

I asked her about the question of joint pain and this was her response:

" Hello all, I have seen postings about joint pain and Xolair. As head nurse for

Xolair in a Specialty Pharmacy and tracking each & every person on it, I never

heard joint pain from any one I spoke to. Repetative motion causes joint pain,

Arthritis of any kind does also. Being on prednisone and now off could be the

culprit. Most of us are heavier than the norm due to the prednisone and extra

weight causes joints to work harder. So, see your physician, have them draw

labs for arthritis, take x-rays of affected areas & formulate treatment plans.

I highly doubt there is any correlation beween Xolair & joint pain. Warm

compresses never hurt & will help the pain. Some people prefer cold compresses.

Hope this helps

Pat "

[Guest guest]

Hi Everyone,

On the website's safety information it does state that joint pain was a

significant (I say significant without 'statistical' in front of it) finding,

compared to placebo with an 8% greater incidence. I find this to be impressive.

I called Genentech regarding this figure, looking for the source data to give

context (i.e. was it seen in their registry trials, other trials, or through

post-marketing surveillance). They are going to contact me soon with more

specific info.

The website does make mention to discuss these findings with your physician.

There is the question of a auto-antibody reaction (anti-IgG-anti-IgE-IgG) which

might lead immunolgic products, depositing in certain areas, leading to a

rheumatologic issue with joints, simulating arthritis. However, so far, there

have not been any instances of this.

my $0.02

Glenn

________________________________

From: Db <uca79iii@...>

Sent: Sun, February 27, 2011 4:43:04 PM

Subject: [ ] From Pat, our xolair nurse

I asked her about the question of joint pain and this was her response:

" Hello all, I have seen postings about joint pain and Xolair. As head nurse for

Xolair in a Specialty Pharmacy and tracking each & every person on it, I never

heard joint pain from any one I spoke to. Repetative motion causes joint pain,

Arthritis of any kind does also. Being on prednisone and now off could be the

culprit. Most of us are heavier than the norm due to the prednisone and extra

weight causes joints to work harder. So, see your physician, have them draw

labs for arthritis, take x-rays of affected areas & formulate treatment plans.

I highly doubt there is any correlation beween Xolair & joint pain. Warm

compresses never hurt & will help the pain. Some people prefer cold compresses.

Hope this helps

Pat "

[Guest guest]

Thanks Glen.

Glen is the pharmacist of our group and I asked him to give his professional

advice on the issue of joint pain

Doug

[Guest guest]

I did a bit of research and found an interestingly higher incidence of arthalgia

for injections vs. Tablets and capsules. Could the mode of delivery account for

some of the joint pain? Thus far I have not been able to see a connection

between anti-IgE and joint deposits.

Am I off track?

Sheila

Sent from my BlackBerry® smartphone

-----Original Message-----

From: GW <fpa9@...>

Sender:

Date: Wed, 2 Mar 2011 12:04:32

< >

Reply-

Subject: Re: [ ] From Pat, our xolair nurse

Hi Everyone,

On the website's safety information it does state that joint pain was a

significant (I say significant without 'statistical' in front of it) finding,

compared to placebo with an 8% greater incidence. I find this to be impressive.

I called Genentech regarding this figure, looking for the source data to give

context (i.e. was it seen in their registry trials, other trials, or through

post-marketing surveillance). They are going to contact me soon with more

specific info.

The website does make mention to discuss these findings with your physician.

There is the question of a auto-antibody reaction (anti-IgG-anti-IgE-IgG) which

might lead immunolgic products, depositing in certain areas, leading to a

rheumatologic issue with joints, simulating arthritis. However, so far, there

have not been any instances of this.

my $0.02

Glenn

________________________________

From: Db <uca79iii@...>

Sent: Sun, February 27, 2011 4:43:04 PM

Subject: [ ] From Pat, our xolair nurse

I asked her about the question of joint pain and this was her response:

" Hello all, I have seen postings about joint pain and Xolair. As head nurse for

Xolair in a Specialty Pharmacy and tracking each & every person on it, I never

heard joint pain from any one I spoke to. Repetative motion causes joint pain,

Arthritis of any kind does also. Being on prednisone and now off could be the

culprit. Most of us are heavier than the norm due to the prednisone and extra

weight causes joints to work harder. So, see your physician, have them draw

labs for arthritis, take x-rays of affected areas & formulate treatment plans.

I highly doubt there is any correlation beween Xolair & joint pain. Warm

compresses never hurt & will help the pain. Some people prefer cold compresses.

Hope this helps

Pat "