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- I posted this originally back in February. You really need to

get a prescription from a doctor that understands .

We were told to use a second dose only if the first dose didn't knock

out the fever.

Our daughter reacted highly to the Prednisone - became totally wild. So

we had to use a very small dosage.

Typically the fevers also come closer (ours came every 10-12 days) when

we used the 2 mg/kg dosage.

Ultimately, we determined that 4-7 day fevers every 20-30 days was too

much to deal with and the Prednisone really affected her personality -

so we opted for a T & A. While not for everyone, it has worked for us so

far. We've now gone over 6 months without a fever.

Hopefully the below information will help:

Message 20426:

I see a ton of posts that discuss doses of Prednisone in teaspoons. My

concern when I read these is that it all depends on weight of your child

(just like Motrin and Tylenol)... So I thought this might help some of

you figure out the math and what dosage your doctors are

recommending.... Please bear in mind that this is for a 15mg/5ml Orapred

solution.

Typical dosage recommendation is 1-2 mg/kg ---- note that a kg is about

2.2 pounds

Also note that our Orapred dosage is 15mg/5mls (or 15 mgs per Teaspoon)

To figure out pounds to kgs to figure out the dosage here's a

calculation you can do:

LB weight * .45 / 15 = Teaspoon for 1mg/kg Dosage

OR

LB weight * .45 / 3 = ML for 1mg/kg Dosage

If your doctor is recommending 2mg/kg then you would double the result

above.

For example a 32 pound child is about 14.4 kgs. And at 15 mg/5 mls (our

form of Orapred) - you would get 32x.45=14.44/15=.96 (or Roughly 1

teaspoon).

We found that a .6mg/kg dose was about right for our daughter. She'd

run a low 100 the day after, but didn't seem to impact her as much

emotionally and the fevers spread out to about 25-35 days.

Our daughter was 34 pounds and 3 mls worked for her (so that equates to

about a .6mg dosage per kg)

For those that get really confused with all the mls, kgs, mgs -

especially when we use pounds in the US ---- I hope that the above helps

you.

BUT if for any reason you do it and the dosage seems WAY off... please

check with a pharmacist or your doctor first.

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For our 5 year-old daughter, we give one dose (we're using the Orapred

tablets, 15 mg dose) when we're sure that it's a fever episode and it

starts spiking up. We give a second dose 24 hours later. We have

found that the initial dose knocks the fever out and she's pretty much

back to normal after a few hours, but if we don't give the second dose,

the fever returns a day or so later and is then not very responsive to

the prednasone. It works really well for her, except we're now trying

to figure out if it's making her fevers come more frequently. It's not

clear cut, since she's had longer spells right after a prednisone dose,

and shorter spells without one (we haven't given it every single

time). But overall, her fevers have increased to every three weeks on

average for the past six months, so we don't know if it's connected to

the prednasone or not. We're scheduling a T & A for this summer, because

it's just too frequent now.

Best wishes,

Margie

mom of 5 year-old Rowan with and 2 year-old Liam

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Guest guest

For our 5 year-old daughter, we give one dose (we're using the Orapred

tablets, 15 mg dose) when we're sure that it's a fever episode and it

starts spiking up. We give a second dose 24 hours later. We have

found that the initial dose knocks the fever out and she's pretty much

back to normal after a few hours, but if we don't give the second dose,

the fever returns a day or so later and is then not very responsive to

the prednasone. It works really well for her, except we're now trying

to figure out if it's making her fevers come more frequently. It's not

clear cut, since she's had longer spells right after a prednisone dose,

and shorter spells without one (we haven't given it every single

time). But overall, her fevers have increased to every three weeks on

average for the past six months, so we don't know if it's connected to

the prednasone or not. We're scheduling a T & A for this summer, because

it's just too frequent now.

Best wishes,

Margie

mom of 5 year-old Rowan with and 2 year-old Liam

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Guest guest

For our 5 year-old daughter, we give one dose (we're using the Orapred

tablets, 15 mg dose) when we're sure that it's a fever episode and it

starts spiking up. We give a second dose 24 hours later. We have

found that the initial dose knocks the fever out and she's pretty much

back to normal after a few hours, but if we don't give the second dose,

the fever returns a day or so later and is then not very responsive to

the prednasone. It works really well for her, except we're now trying

to figure out if it's making her fevers come more frequently. It's not

clear cut, since she's had longer spells right after a prednisone dose,

and shorter spells without one (we haven't given it every single

time). But overall, her fevers have increased to every three weeks on

average for the past six months, so we don't know if it's connected to

the prednasone or not. We're scheduling a T & A for this summer, because

it's just too frequent now.

Best wishes,

Margie

mom of 5 year-old Rowan with and 2 year-old Liam

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Hello,

I just joined this group today, so glad to have found it. My 4 1/2 was

diagnosed a year ago with . We started prednisone last year and

now we are using orapred, same dosage as you. I have noticed that the

episodes have increased. Yes, the orapred takes away the symptoms

within a few hours, however the fever will be back within 4-5 days (our

typical cycle is every 2 weeks). Our doctor recommeneded giving the

second dose 24 hours later, he said steriod treatment can increase the

episodes, I never had this on prednisone although they say orapred is

the same thing. We tried it this way once and found we gained 2 more

days in between. I am so confused because I don't think steriods are

a " great " thing to be on. We did have two weeks in between episodes

the last time and we only did the orapred once. We had an episode

yesterday, gave him the orapred so anxious to see how long we get until

the next time. Are you having the tonsils removed? Curious to see

your opinion on that I keep reading conflicting info. Take Care!

Jackie, Landon's mom

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Hello,

I just joined this group today, so glad to have found it. My 4 1/2 was

diagnosed a year ago with . We started prednisone last year and

now we are using orapred, same dosage as you. I have noticed that the

episodes have increased. Yes, the orapred takes away the symptoms

within a few hours, however the fever will be back within 4-5 days (our

typical cycle is every 2 weeks). Our doctor recommeneded giving the

second dose 24 hours later, he said steriod treatment can increase the

episodes, I never had this on prednisone although they say orapred is

the same thing. We tried it this way once and found we gained 2 more

days in between. I am so confused because I don't think steriods are

a " great " thing to be on. We did have two weeks in between episodes

the last time and we only did the orapred once. We had an episode

yesterday, gave him the orapred so anxious to see how long we get until

the next time. Are you having the tonsils removed? Curious to see

your opinion on that I keep reading conflicting info. Take Care!

Jackie, Landon's mom

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Guest guest

Hello,

I just joined this group today, so glad to have found it. My 4 1/2 was

diagnosed a year ago with . We started prednisone last year and

now we are using orapred, same dosage as you. I have noticed that the

episodes have increased. Yes, the orapred takes away the symptoms

within a few hours, however the fever will be back within 4-5 days (our

typical cycle is every 2 weeks). Our doctor recommeneded giving the

second dose 24 hours later, he said steriod treatment can increase the

episodes, I never had this on prednisone although they say orapred is

the same thing. We tried it this way once and found we gained 2 more

days in between. I am so confused because I don't think steriods are

a " great " thing to be on. We did have two weeks in between episodes

the last time and we only did the orapred once. We had an episode

yesterday, gave him the orapred so anxious to see how long we get until

the next time. Are you having the tonsils removed? Curious to see

your opinion on that I keep reading conflicting info. Take Care!

Jackie, Landon's mom

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Hi -

Welcome, I know you will find this site useful as well as therapeutic. I have

found that if I give the orapred too soon the fever comes back in a few days so

I wait until the fever is about 102 then give it to my daughter. I know info.

was posted on this awhile back on this site. Hope this helps.

Lynn

]

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Thank you Lynn!  I noticed during the last episode I did give the orapred a day

after it started and we did get a longer period of time in between episodes. 

Take Care.

Jackie

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Thank you Lynn!  I noticed during the last episode I did give the orapred a day

after it started and we did get a longer period of time in between episodes. 

Take Care.

Jackie

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  • 2 months later...

Hi Frances

Is that fluid, protein or fats you are loosing?

Methotrexate is an antimetabolite...may impede protein (muscle) repair

unless the catabolic effect is a desired outcome.

I wonder if you've activated the adipocytes into releasing some of the

fats, then burning them off?

best wishes

Bob

> Hi All

> I expect this seems an odd question but here goes anyway. I have been

> hypothyroid for many years and take 5 grains of Armour Thyroid.

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Thanks for that Bob. You may well be right. It will be interesting to

see if the weight loss continues. At least my Arthritis seems a little

better!

Regards Frances

> > Hi All

> > I expect this seems an odd question but here goes anyway. I have been

> > hypothyroid for many years and take 5 grains of Armour Thyroid.

>

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>

> Recently I have been diagnosed with Psoriaic Arthritis and been put on

> Methaltrexate (175 mg) and Prednisolone.(20mg).I have now been taking

> >

> What I wondered is does prednisolone work on the adrenals. Could this

> have made my Armour work better and therefore caused the weight loss

Hi

I will bow to Bob's greater knowledge, but certainly prednisilone is

used for adrenal support (in smaller doses) and so it may have helped

the armour be used better. It is the same stype of steroid as

hydrocortisone but is much longer acting.

Either way, I'm glad it's helping you.

Leah x

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Hi Frances

Yes, Prednisolone is used in adrenal insufficiency, and the fact that you have been taking it and suddenly started to lose weight is because you obviously had low adrenal reserve and your body was unable to absorb all the thyroid hormone you were taking, so quite simply, it wasn't doing the job it should. Once people get their adrenals boosted, they often find they do not need as much thyroid as they were taking before. Obviously, your metabolism has started to speed up, so you will lose the weight. You really should have been told to stop your thyroid hormone when you started taking Prenisolone and then start your Armour again at a reduced rate and build it up again after a couple of weeks. Also, 20 mg Prednisolone seems a large dose. You can take either Hydrocortisone - Prednisolone - Methyprednisolone or Dexamethasone to boost your adrenals. You hit on the right medication obviously.

Luv - Sheila

What I wondered is does prednisolone work on the adrenals. Could thishave made my Armour work better and therefore caused the weight lossor could I have retained a lot of fluid and something is acting like adiuretic.The pain is getting better so I know the methaltrexate iskicking in at last and causing some of the swelling to go down but itseems such a fortuitous side effect. Regards FrancesNo virus found in this incoming message.

Checked by AVG - http://www.avg.com Version: 8.0.138 / Virus Database: 270.6.10/1638 - Release Date: 27/08/2008 19:06

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Hi Frances,

[[...For psoriasis, the starting oral dose is a single 7.5 mg dose weekly or 2.5 mg every 12 hours for three doses, once weekly....]] http://www.medicinenet.com/methotrexate/article.htm

Was there a mix-up over this number on you post?

best wishes

Bob

>> Hi All> > I expect this seems an odd question but here goes anyway. I have been

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Hi Bob

The dose of metheltrexate is what the rhumatoligist prescribed and I

have not had much problem with side affects so i can only suppose it

is OK. My GP was quite happy with it too.I started with 6x2.5mg once a

week for three weeks now I am on 7x2.5 per week for three weeks and

then I go up to 8x2.5 mg and stay on that until I see her again.Don't

forget this is for psoriaic arthritis.

Many thanks

Frances

> >

> > Hi All

> >

> > I expect this seems an odd question but here goes anyway. I have been

>

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....and doesn't that decimal point make a massive difference ??

Luv - Sheila

Methaltrexate (175 mg) and Prednisolone.(20mg).I have now been taking

the decimal point is missing....lol

Bob

.. No virus found in this incoming message.

Checked by AVG - http://www.avg.com Version: 8.0.138 / Virus Database: 270.6.10/1638 - Release Date: 27/08/2008 19:06

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  • 6 months later...
Guest guest

We had the same problem and had to stop using it because of behavior issues on

the medicine.  I have heard that for some people if you continue to use it they

will space back out. 

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Guest guest

My sons fever will go away for a day and then return the next and when he takes

it he cycles every two weeks instead of every 28 days.If he doesnt use it his

fevers will go as high as 106 We really have no choice but to take it .He will

go next month to have a T & A we are hoping this will work.

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Guest guest

I was told by our doctor if the fever does not go away with the first dose that

we can give a second 12 hours later. Have any of you heard this? Klara is newly

diagnosed and has been having fevers for a year but only had predisone once. I

have a feeling another fever is coming soon though

and Bouman

29:11

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Guest guest

That is the EXACT same scenario we had with the first dose. Teagan gets only

swollen glands and her head hurts. Hers came back about 18 hrs after dose. The

next cycle it worked like a charm!

Stacey

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Our doctor advised the same thing. We only had it not work the first time and

we opted not to give her a second dose. I don't like how wired it makes her so

I doubt that we would ever go for the second dose

Stacey

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  • 6 months later...

Prednisolone and prednisone dosages are based on the child's weight (and

sometimes are adjusted depending on how the child responds to the medication),

so not all 5 year-olds would get the same dose.

Hope that helps-

Kathy (Pediatric RN)

mom of Josh (TRAPS / )

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