Glutathione Implants: was Re: Protandim

[Guest guest]

One less item to add to my wish list. Thanks Duncan.

Alobar

On Sat, Mar 12, 2011 at 12:14 PM, Duncan Crow <duncancrow@...> wrote:

> From what I understand of the research, though a glutathione enteric coated

oral or suppository product reaches the bowel lining, one of just 3-4 types of

cells that can suck up glutathione locally, glutathione is known to not pass

membranes to enter the bloodstream, or even most cell types. A

glutathione-sparing effect was proposed in the research with this type of local

treatment.

>

> There is some indication that liposomal glutathione may pass bowel membranes

and enter the blood serum, but again, not most cell types.  I'd check the scant

details and see if it's been proven adequately to date. If it has, I'd say it's

a better bet than non-liposomal enteric or suppositories.

>

> all good,

>

> Duncan

>

>

>>

>> Duncan,

>> Here is a glutathione question for you.

>>

>> About a month ago, I posted a link to   Therapies for Airborne Poisons

>> by Marc Sircus

>>  http://www.healthfreedomusa.org/?p=5783

>> along with a request for recommendations for those living near the

>> Gulf who are dealing with airborn toxicity.

>>

>> In the article, Marc Sircus states,

>> " Intravenous glutathione is best for emergency application but our

>> recommendation for treating Gulf Toxicity Syndrome is to use

>> suppositories, which are about 60 percent as effective as IVs. "

>>

>> What is your opinion of the usefulness of glutathione suppositories?

>> http://www.drvitaminsolutions.com/index.php?l=product_detail & p=590

>> Would they be good as an adjunct to whey+Selenium?  Can one have too

>> much Glutathione in one's body?

>>

>> Alobar

[Guest guest]

NeuroScience 2009

Title: Liposomal glutathione for replenishment and maintenance of

intracellular glutathione in mesencephalic cultures

Presentation: Oct 18, 2009 @ Society for Neuroscience Annual Meeting

Authors: *G. ZEEVALK1, F. T. GUILFORD2, L. P. BERNARD1;

1UMDNJ RW Med. School, Piscataway, NJ; 2Your Energy Systems,

LLC, Palo Alto, CA

" Lipoceutical glutathione ( from Autism Coach)

caused my son to regain his speech after 1 month of treatment!! " As

posted on Answers by momwhoknows.

Abstract: Glutathione (GSH) is the major small molecule thiol

antioxidant in all cells including the brain. Alterations in GSH are

implicated in a number of neuropathological and neurodegenerative

conditions including Parkinson¢s disease, autism, schizophrenia and

HIV. Maintenance and/or repletion of intracellular GSH in neuronal

cells may, therefore, be of neuroprotective benefit for a variety of

pathological conditions. Here we studied a liposomal formulation of

GSH consisting of reduced GSH encapsulated in lipid vesicles

consisting of hydroxylated lecithin, glycerin and potassium sorbate

for its ability to replenish intracellular levels of GSH in mixed

neuronal and glial mesencephalic cultures. Mesencephalic cultures

contain presumptive midbrain dopamine neurons which are the neurons

that degenerate in Parkinson¢s disease. Cultures were transiently

depleted of GSH by 60% with a 30min pretreatment with diethyl maleate.

Repletion of intracellular GSH was followed over 4 hr in a Krebs

Ringer containing either no additives, GSH amino acid substrates

glutamine, cysteine and glycine (for optimal repletion) or various

concentrations of non-liposomal GSH (non-L-GSH) or liposomal-GSH

(L-GSH). No repletion of GSH was observed in the absence of additives,

whereas precursor amino acids, L-GSH and non-L-GSH fully restored

intracellular GSH to control levels by 4 hr. L-GSH was 100-fold more

potent than non-L-GSH in replenishing intracellular GSH (4.75uM vs

533uM for L-GSH and non-L-GSH, respectively). Blockade of GSH

biosynthesis with buthionine sulfoximine (10uM) completely prevented

replenishment by L-GSH indicating that hydrolysis and resynthesis was

required for utilization. Preliminary studies with acivicin, an

inhibitor of the ecto-enzyme ã-glutamyl transpeptidase, which

metabolizes GSH in the extracellular milleiu, did not prevent

repletion, whereas, 3-methyladenine, an inhibitor of autophagy showed

partial inhibition of repletion by L-GSH. These findings suggest that

L-GSH is not metabolized extracellularly and may be taken up by the

endosomal system for hydrolysis and intracellular supply of precursor

amino acids. Additional studies are being conducted to determine if

L-GSH replenishes GSH specifically in neurons and if it can provide

protection from oxidative challenge. While it remains to be

investigated whether L-GSH can gain entry to the CNS, studies in

neuronal cultures in vitro demonstrate its utility for maintenance

and/or repletion of GSH in neuronal cells with high potency. L-GSH may

thus offer promise as a means for brain maintenance of GSH in

conditions where perturbation of GSH has been implicated in disease

etiology.

Glutadione - LiposomaL

http://www.autismcoach.com/Glutathione%20-%20Liposome%20Form.htm

With regards

Lew

On 3/13/11, Alobar <Alobar@...> wrote:

> One less item to add to my wish list. Thanks Duncan.

>

> Alobar

>

> On Sat, Mar 12, 2011 at 12:14 PM, Duncan Crow <duncancrow@...> wrote:

>> From what I understand of the research, though a glutathione enteric

>> coated oral or suppository product reaches the bowel lining, one of just

>> 3-4 types of cells that can suck up glutathione locally, glutathione is

>> known to not pass membranes to enter the bloodstream, or even most cell

>> types. A glutathione-sparing effect was proposed in the research with this

>> type of local treatment.

>>

>> There is some indication that liposomal glutathione may pass bowel

>> membranes and enter the blood serum, but again, not most cell types.  I'd

>> check the scant details and see if it's been proven adequately to date. If

>> it has, I'd say it's a better bet than non-liposomal enteric or

>> suppositories.

>>

>> all good,

>>

>> Duncan

>>

>>

>>>

>>> Duncan,

>>> Here is a glutathione question for you.

>>>

>>> About a month ago, I posted a link to   Therapies for Airborne Poisons

>>> by Marc Sircus

>>>  http://www.healthfreedomusa.org/?p=5783

>>> along with a request for recommendations for those living near the

>>> Gulf who are dealing with airborn toxicity.

>>>

>>> In the article, Marc Sircus states,

>>> " Intravenous glutathione is best for emergency application but our

>>> recommendation for treating Gulf Toxicity Syndrome is to use

>>> suppositories, which are about 60 percent as effective as IVs. "

>>>

>>> What is your opinion of the usefulness of glutathione suppositories?

>>> http://www.drvitaminsolutions.com/index.php?l=product_detail & p=590

>>> Would they be good as an adjunct to whey+Selenium?  Can one have too

>>> much Glutathione in one's body?

>>>

>>> Alobar

>

[Guest guest]

This study shows some specific brain cells can soak up liposomal glutathione. A

test tube study doen't indicate in-vivo results though, and no systemic effect

was measured.

" While it remains to be

> investigated whether L-GSH can gain entry to the CNS, studies in

> neuronal cultures in vitro demonstrate its utility for maintenance

> and/or repletion of GSH in neuronal cells with high potency. "

Systemic action is important; after it enters the body the liposomal glutathione

should remain liposomal long enough to be distributed, cross the blood-brain

barrier and elevate brain glutathione.

What motivates medical research is the use of glutathione as a drug as opposed

to a more natural method of using dietary precursors, which are systemic in

action.

You can make your own liposomal glutathione and hold it in a retentive enema.

I'd suggest also undenatured whey and selenium for the dietary precursors

regardless.

all good,

Duncan