Re: Secretin

[Guest guest]

<< I would however remind you guys that there are extremely

> > serious risks

> > involved

> > with the secretin injections. We are not talking side effects

> > that can go away here. We are talking risks of permanent, long

> > term, and potentially lethal dangers. Some of these dangers can

> > take months to manifest themselves and

> > there

> > is no cure for them (mad cow disease like...). >>

What serious risks? What permanent, long term, and potentially lethal

dangers?

It's one thing to offer a word of caution... in this case you it seems you

are crossing the line and posting extreme points about a medicine with which

you have little or no actual knowledge.

Ferring's porcine secretin has been used since the early 80's for pancreatic

function testing. There have been no known permanent or long-term

consequences from having had a secretin infusion since that time. In Japan,

their Porcine derived secretins (Gaspretin and Secrepan) have been in use

for about as long. There they have used I.V. secretin for more than

pancreatic function testing with patients receiving multiple infusions.

Again, there are no known cases of any permanent or long-term damage because

of these infusions. The risk of doing a single infusion would probably rate

as close to 0 as taking Motrin.

Secretin was the first hormone ever discovered in large part because it is a

relatively simple hormone -- I believe only 27 amino acids in length.

Porcine secretin differs from human secretin by 3 amino acids, all of which

are the more neutral amino acids. This means that the porcine secretin is

very unlikely to kick-off an auto-immune response to our own secretin. In

addition, synthetic human secretin is now in trials including Children's

Hospital in Philadelphia. If they thought there were any long-term risks,

you had better believe they wouldn't be doing the study. (I am worried

about a synthetic human secretin that some parents may be using because,

currently, there is no synthetic form that is FDA approved. This means

parents are using a commercial product not intended for human

administration, and impurities could exist which could be dangerous.)

It might be probably be better to administer secretin in a repeated low dose

format than the high dose I.V. push so as not to stress the pancreas but

again we don't know. Do you? It's up to parents and doctors to do there

research and make appropriate decisions for their children. Dr. Goldberg

has made his arguments against secretin based on his medical knowledge.

While I may not agree with his points, I respect them.

[Guest guest]

FINE !

Jeff Stone wrote:

> From: " Jeff Stone " <ETIGUY@...>

>

> << I would however remind you guys that there are extremely

> > > serious risks

> > > involved

> > > with the secretin injections. We are not talking side effects

> > > that can go away here. We are talking risks of permanent, long

> > > term, and potentially lethal dangers. Some of these dangers can

> > > take months to manifest themselves and

> > > there

> > > is no cure for them (mad cow disease like...). >>

>

> What serious risks? What permanent, long term, and potentially lethal

> dangers?

>

> It's one thing to offer a word of caution... in this case you it seems you

> are crossing the line and posting extreme points about a medicine with which

> you have little or no actual knowledge.

>

> Ferring's porcine secretin has been used since the early 80's for pancreatic

> function testing. There have been no known permanent or long-term

> consequences from having had a secretin infusion since that time. In Japan,

> their Porcine derived secretins (Gaspretin and Secrepan) have been in use

> for about as long. There they have used I.V. secretin for more than

> pancreatic function testing with patients receiving multiple infusions.

> Again, there are no known cases of any permanent or long-term damage because

> of these infusions. The risk of doing a single infusion would probably rate

> as close to 0 as taking Motrin.

>

> Secretin was the first hormone ever discovered in large part because it is a

> relatively simple hormone -- I believe only 27 amino acids in length.

> Porcine secretin differs from human secretin by 3 amino acids, all of which

> are the more neutral amino acids. This means that the porcine secretin is

> very unlikely to kick-off an auto-immune response to our own secretin. In

> addition, synthetic human secretin is now in trials including Children's

> Hospital in Philadelphia. If they thought there were any long-term risks,

> you had better believe they wouldn't be doing the study. (I am worried

> about a synthetic human secretin that some parents may be using because,

> currently, there is no synthetic form that is FDA approved. This means

> parents are using a commercial product not intended for human

> administration, and impurities could exist which could be dangerous.)

>

> It might be probably be better to administer secretin in a repeated low dose

> format than the high dose I.V. push so as not to stress the pancreas but

> again we don't know. Do you? It's up to parents and doctors to do there

> research and make appropriate decisions for their children. Dr. Goldberg

> has made his arguments against secretin based on his medical knowledge.

> While I may not agree with his points, I respect them.

>

> ---------------------------

[Guest guest]

Hi. My name is Margie and I have been following your discussion about

secretin. I have a 6 year old son named who falls somewhere along the

autistic spectrum and fits the profile. He had his first secretin

infusion in February of this year. I have seen so many positive improvements

in his behavior, his communication skills, and his overall emotional

availability since we began using secretin that it is difficult for me to

read posts that speak negatively about secretin. I am certainly aware that

the use of secretin is experimental and that we have no idea what the long

term effects of using it will be. After attending several of the initial

secretin conferences, however, I knew that I could not NOT try it. I found a

doctor who I trust, and infused my son, who, at the time, was not talking

enough or emotionally available enough to be consulted. I attended the

conference in May and learned quite a bit. I believe wholeheartedly in what

the group is proposing and plan to add antifungal/antiviral medications

to the regimen of things my son currently ingests. I am also continuing to

use other therapies to assist my son in his progress. I just wanted to let

everyone know that we are having an extremely positive experience with

secretin. And my son, who takes secretin drops each morning, is able to tell

me that it is okay to take the drops because they are helping him learn to

talk. Margie

[Guest guest]

We are all very happy for you Margie ! Sounds like you made the right decision.

Knightmls@... wrote:

> From: Knightmls@...

>

> Hi. My name is Margie and I have been following your discussion about

> secretin. I have a 6 year old son named who falls somewhere along the

> autistic spectrum and fits the profile. He had his first secretin

> infusion in February of this year. I have seen so many positive improvements

> in his behavior, his communication skills, and his overall emotional

> availability since we began using secretin that it is difficult for me to

> read posts that speak negatively about secretin. I am certainly aware that

> the use of secretin is experimental and that we have no idea what the long

> term effects of using it will be. After attending several of the initial

> secretin conferences, however, I knew that I could not NOT try it. I found a

> doctor who I trust, and infused my son, who, at the time, was not talking

> enough or emotionally available enough to be consulted. I attended the

> conference in May and learned quite a bit. I believe wholeheartedly in what

> the group is proposing and plan to add antifungal/antiviral medications

> to the regimen of things my son currently ingests. I am also continuing to

> use other therapies to assist my son in his progress. I just wanted to let

> everyone know that we are having an extremely positive experience with

> secretin. And my son, who takes secretin drops each morning, is able to tell

> me that it is okay to take the drops because they are helping him learn to

> talk. Margie

>

> ---------------------------

[Guest guest]

, I have no experience with oral secretin, only use it as a cream, but

for it to work well you should have him on a milk free antiyeast diet as well

as treating any yeast overgrowth in the gut with perscription antifungals.

Beverly

[Guest guest]

Hi ,

CFS researcher, Dr. Goldberg has replied to questions on

Secretin on his conference section where he answers questions, you have to

sign up to ask questions for the conference link(Q & A) section, it's free.

Site is at:

www.neuroimmunedr.com

Al

Secretin

> Recently someone posted about Autism site and it had many things on it

that

> described our situation. One of the things it talks about is secretin. I

> have been thinking about secretin lately and trying to learn a little bit

> more about it. I hear it helps in malabsorption problems which I have

really

> bad. I am taking a hundred different things and on most days I feel I am

> wasting my time because I am not absorbing everything correctly. My

stomach

> always hurts and I am constantly constipated. This could be from yeast,

> bacteria, a whole bunch of reasons but has anyone given secretin any

thought

> or do you know more about it?

>

>

[Guest guest]

> Recently someone posted about Autism site and it had many things on it that

> described our situation. One of the things it talks about is secretin. I

> have been thinking about secretin lately and trying to learn a little bit

> more about it. I hear it helps in malabsorption problems which I have really

> bad. I am taking a hundred different things and on most days I feel I am

> wasting my time because I am not absorbing everything correctly. My stomach

> always hurts and I am constantly constipated. This could be from yeast,

> bacteria, a whole bunch of reasons but has anyone given secretin any thought

> or do you know more about it?

,

I recommend that you check the site www.krysalis.net/autism.htm

Dr. Gregg has been making some real progress on the secretin front. He is

now supplying freeze dried pig duodenum powder to people with autism and also

with Crohn's disease. It seems to help for a subset of each, and he believes it

is because the powder contains prosecretin, which is the precursor of the

hormone secretin. Injections of the actual secretin have been shown not to

work. Dr. Gregg believes this is because the secretin must enter the

bloodstream when it is actually needed to trigger pancreatic juice secretion in

response to acidic chyme entering from the stomach. For this to occur, the

person must have prosecretin rather than secretin.

I think the pig duodenum powder may hold promise for a subset of PWCs who have a

malabsorption problem. Generally, these are " skinny " PWCs.

Rich

[Guest guest]

Hi,

We just started using the transdermal secretin on our three year old son aboout 4 days ago. Has anyone else had trouble with stinging when applying ? I assume it's the Dmso that would be the problem? It was suggested that we try applying 1 teasp. of salt (not iodiozed) to 8 ozs. of water. Before the secretin we were told to rub the salt solution briskly on his back. This did help some. It still bothers him enough that I feel as though I'm torturing him everytime I do this! I contacted the pharmacy about maybe a different base other then dmso, is there such a thing? Someone suggested Lanolin, but would this transport the secretin ?? If ANYONE has any suggestions, Boy would I apprecitate It!!

Patti

[Guest guest]

Patti

We have no problems with transdermal secretin.

Question: Does it leave a rash when applied?

Jeff was a little afraid of it when we first started applying it.

Must be because of the texture and coldness of the product.

What does your doctor think?

a Jeffs mom

[ ] Re: Secretin

Hi,

We just started using the transdermal secretin on our three year old son

aboout 4 days ago. Has anyone else had trouble with stinging when applying ?

I assume it's the Dmso that would be the problem? It was suggested that we

try applying 1 teasp. of salt (not iodiozed) to 8 ozs. of water.

[Guest guest]

Patti,

My son developed quite a reaction to the dmso and our pharmacist

developed another base. I can't remember what it is exactly. I don't

think we got very good penetration of the secretin though becaus the

improvements we had been seeing in his stool disappeared even when on

this new transdermal secretin. If you want to check into it you could

call my pharmacist, Lionel at Santa Clara Drug (408) 296-5015.

Good luck,

Chris

On Tue, 27 Feb 2001 11:23:26 -0500 " G Gamble " <seeker@...> writes:

> Hi,

>

> We just started using the transdermal secretin on our three year old

> son aboout 4 days ago. Has anyone else had trouble with stinging

> when applying ? I assume it's the Dmso that would be the problem? It

> was suggested that we try applying 1 teasp. of salt (not iodiozed)

> to 8 ozs. of water. Before the secretin we were told to rub the salt

> solution briskly on his back. This did help some. It still bothers

> him enough that I feel as though I'm torturing him everytime I do

> this! I contacted the pharmacy about maybe a different base other

> then dmso, is there such a thing? Someone suggested Lanolin, but

> would this transport the secretin ?? If ANYONE has any suggestions,

> Boy would I apprecitate It!!

> Patti

>

>

>

[Guest guest]

Maybe the adhesive?

S

--------------------------------------------------------------

Patti

Secretin does not leave a mark on my son or friends (about 5 other families)

using transdermal secretin.

Can it be your child is allergic to an ingredient??

Thoughts?

a jeffs mom

[Guest guest]

Thanks for all responses. , it does leave his back red wherever its applied. I think I may just kept doing it for awhile and see if he can get use to it. I would hate to change the base, and not know if it's actually working or not!

Patti

[Guest guest]

Patti

Secretin does not leave a mark on my son or friends (about 5 other families)

using transdermal secretin.

Can it be your child is allergic to an ingredient??

Thoughts?

a jeffs mom

[Guest guest]

,

That was my first thought, that my son might be allergic to it. I decided to try it again tonight. Thanks to Mr. Laidler's suggestion, I tryed it on his leg instead of his lower back, and he hardly fussed at all. I guess it's possible that he may just be more sensitive in that area!Thanks to all!!

Patti

[Guest guest]

Both my child and a friend's boy complained initially about secretin -

not that it hurt, but that it was weird and uncomfortable. We both

started applying some of the doses when the kids were asleep to give

them a break. But after a little while (maybe a week or two?), the

complaints stopped.

> Hi,

>

> We just started using the transdermal secretin on our three year

old son aboout 4 days ago. Has anyone else had trouble with stinging

when applying ? I assume it's the Dmso that would be the problem?....

If ANYONE has any suggestions, Boy would I apprecitate It!!

> Patti

[Guest guest]

Who is Lawrence Leichman?

Message: 3

Date: Sun, 3 Jun 2001 02:07:54 EDT

From: drew9589@...

Subject: Secretin

What is it?

Secretin is a hormone that is used to cause a release of another hormone

(cholecystokinin, CCK) in the body and increase the carbon dioxide status

of

the intestine to assist absorption of fats using other pancreatic

enzymes. In

addition, it is known that Secretin receptors exist in the brain and on

the

white blood cells. It is not known if changes in the intestine affect

central

nervous system reactions.

Why does it work in autism?

In patients who respond it causes changes in serotonin levels in the

brain

and also influences tyrosine hydroxylase which causes an increase in

another

neurotransmitter dopamine. What actions these may have directly is

unknown.

Is it risky?

Getting an Intravenous Drug is risky because of the act of placing an IV,

but

serious allergic reactions with Secretin have not occurred so far. If

they

do, they can be handled with epinephrine or Benadryl and not ever getting

pork products IV again. This is an IV push and not a drip so the time

needed

to infuse is short. We do expect that prolonged periods of IV infusion

will

cause the production of antibodies to pork but, as with insulin, this

will

probably result in the product not working rather than severe allergic

reactions.

Are there side effects?

Generally no. Hyperactivity has been reported in 30% of children 1-7 days

after receiving Secretin. This may coincide with behavioral and cognitive

improvements. Otherwise, only a mild non-itchy rash has been seen.

What can you expect?

We're not quite sure. Patients have reported to us improvements in speech

(to

the extent of having speech when none was present before). Potty training

has

occurred in children who have not been potty trained previously and there

has

been cessation of diarrheal stools with normally formed ones. There have

been

behavioral improvements with improved eye contact and lessening of

aggressive

behavior. What is the percentage? We have seen a 70% positive response

and

40% of those have been dramatic responses.

We have seen results in 1-14 days that last for about 6 weeks. No primary

regressions have been reported. For now, we are recommending a follow-up

infusion at 6 weeks if there is a positive result. After 3 to 4 IV

infusions,

we are hoping to go to a transdermal approach using a fast absorbing gel.

Secretin can not be given by patch or by mouth due to breakdown of the

Secretin. I will not use DMSO in children.

Is Secretin in short supply?

Yes, it is currently. The manufacturer, Ferring Pharmaceuticals, did not

really believe the demand they were told to expect and their production

has

not kept up with demand and is controlling allocation. We have had no

trouble

so far getting Secretin.

Why is it so expensive?

Again, due to the large demand, the Secretin itself is very expensive. We

are

seeking alternative resources for Secretin. To date we have had few, if

any,

insurance companies reimburse families but we are willing to help you

file a

third-party claim.

What should my child avoid before or after infusion?

Any behavior medications such as Ritalin, Prozac, Luvox etc. should be

stopped the day before infusion. They can be restarted after infusion.

Antibiotics should also be stopped the day before the infusion and

shouldn't

be restarted for a week after the infusion. If this is not possible then

the

infusion should be rescheduled. No digestive enzymes should be taken the

day

of or within 1 week of infusion. That includes pineapple and papaya that

are

also high in enzymes.

Taken from Dr. Lawrence Leichmans Web site

________________________________________________________________

GET INTERNET ACCESS FROM JUNO!

Juno offers FREE or PREMIUM Internet access for less!

Join Juno today! For your FREE software, visit:

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[Guest guest]

In a message dated 6/3/01 10:16:59 AM Eastern Daylight Time,

dwyer.whynot@... writes:

<<

Who is Lawrence Leichman?

>>

Lawrence G. Leichtman, M.D., FAAP, FACMG

Genetics and Disabilities Diagnostic Care Center

933 First Colonial Road Suite 109

Virginia Beach, VA 23454

757-425-1969

lleichtman@...

lleichtman@...

http://www.macs.net/users/lleichtman

http://www.tri21.org

[Guest guest]

At 09:06 PM 6/14/01 EDT, you wrote:

>Hi all; Zach here.

>

>Anybody out there using a hormone (for their child!) called secretin? Ever

>heard of it for autism treatment? Anybody? My wife saw it on TV.

Yes.

The studies (there are now quite a few) for the effects have not been at

all favorable. I can get some references for you if you want in a few days

(I'll be gone this weekend).

j

[Guest guest]

Hi Zach ,

Here are some websites to checkout on Secretin .

www.DefeatAutismNow.com or www.AutismResearchInstitute.com or

http://www.bhare.org/index.html . Hope this helps .

Irma , 12, DS/ASD .

> Hi all; Zach here.

>

> Anybody out there using a hormone (for their child!) called

secretin? Ever

> heard of it for autism treatment? Anybody? My wife saw it on TV.

>

> Zach w/Dallas, age 7, ds-asd

>

>

>

[Guest guest]

Hi Zach,

Re: Secretin. What I have read about this during the past year, is that

there have been reported cases which were pretty amazing...where children

with autism started immediately speaking after secretin infusion. However,

it seems this is not the overall result...rather actual studies have shown

that in the majority of cases it has made no difference. I don't know if

there are any reported negative side effects.

Lauri

[Guest guest]

This is my understanding of why Dr. G is not an advocate of secretin or

IVIG.

First and foremost is the fact that he believes 99.99% of these kids are not

suffering from a permanent disorder. They have a treatable medical

condition. If you look at these kids in this way then you need to be

concerned of potential long term risks of anything you do.

IVIG and secretin are both products that are introduced into the blood

stream and are from a living source. Anytime you take a substance like this

and introduce it into the bloodstream there is always the potential to pass

on some type of pathogen. This could be some known or unknown virus,

retrovirus, etc. They try to screen things based on what they know now, but

there is still alot to be learned. It was the late 80's when they

discovered HHV6. I keep finding things on what they are calling TTV. It

stands for transfusion transmitted virus. There has also been recent

concerns about foamy viruses in human blood products. Our government has

decided not to test for it at this time. I think everyone has read about

prions and mad cow disease. My understanding is that due to the type of

product secretin is, the way its made and used, in theory the potential is

there for transmittal of viruses, prions, etc. If you transmit something

like a prion, there is no treatment and no cure. Before I knew about Dr. G.

I heard the secretin story. The reason I decided against it at that time

was the concerns being expressed by some doctors of the potential to develop

an autoimmune reaction towards their own secretin. Evidently there was

something similar that happened a long time ago that related to insulin for

diabetics.

We just don't know what the long term risks are, nobody does. It's one

thing when you use something that is related to life or death. The benefits

(life) obviously outweigh the risks. (death)

Cheryl

Government Advisors Split on Need for Further Study of Simian

Foamy Virus

************************************

WASHINGTON (Reuters Health) Dec 13 - Expert advisors to the

US Food and Drug Administration (FDA) were divided on

Thursday on whether to recommend that the agency proceed

with a study to determine whether the simian foamy virus (SFV)

can be spread through the transfusion of blood and blood

products. The FDA asked for the committee's recommendation

because SFV is a retrovirus. At present, there is no evidence

that SFV can cause disease or be transmitted through the

infusion of blood or blood products. However, other crossover

retroviruses have been linked to life threatening diseases and

conditions. FDA officials estimated that the study would cost

around $60,000. But about half the FDA's Blood Products

Advisory Committee expressed concern that this study could

also lead to deferral of potential blood donors based upon a

theoretical risk. Instead, the FDA committee unanimously threw

its weight behind a proposed Centers for Disease Control and

Prevention (CDC) study to determine how prevalent the virus is

among humans and whether the virus can cause disease.

The committee's recommendation was driven in large part by a

CDC occupational analysis, showing a SFV prevalence rate

ranging from 3.7% to 1.05% in people such as zoo keepers and

researchers who work with primates.

The dilemma facing committee members was whether the CDC

survey also suggested the need to study whether SFV can be

transmitted through blood transfusions. On this question, the

committee could not reach a consensus. At dispute was whether

such a study would serve any public health purpose or act as a

simple waste of resources that could, in effect, lead to the

unnecessary screening and deferral of potential blood donors.

The American Association of Blood Banks (AABB) thought that

would be unwarranted. " We applaud the monitoring activities

that are taking place, " said AABB Director of Regulatory Affairs

Kay R. . " At the same time, we would like to emphasize

that available data on SFV suggest action regarding blood

donors is not currently appropriate. "

_________________________________________________________________

Chat with friends online, try MSN Messenger: http://messenger.msn.com

[Guest guest]

Hi,

Thanks for reply. It is seems that Simon has gastrointestinal problems. He

has " leaky gut " and he had (or still has, we are waiting for test results)

high yeast and high " bad " bacteria titer. After 4 weeks of Sporonox his BM

looks much better and he let's say less autistic then he was before. We are

doing vitamins, cod liver oil and proboscis as well. Secretin was

recommended to us by very " traditional " immunologist. He told that Simon

might benefit from injection, because his main problems are speech and

social interaction. Both of them are getting better now. Our doctor uses

pig's secretin from Japan. I know that Dr.Goldberg does not like secretin

much , mainly because its animal source, but I think that people use it for

long period and there are now negative reports related to " pigs itself "

Regina

Dr G's opinion on secretin

>

> >

>

> I've found an allergist here in Md. who a) attended the conference

> believes that the protocol works on some autistic children -

> Dr Layton.

> He's been a doctor for over 25 yrs, starting out first as a pediatrician.

> My 6 yr old son had an appt with him on Wed to discuss local allergies

> (mold/pollen) and some of his quirky food allergies. We're trying to

> determine

> what foods he's really intolerant of. We were pretty impressed with Dr

> Layton.

>

> We had a very thorough 2 hr meeting with him. He agreed with the approach

> Dr G is doing on (based on bloodtests and our feedback)

> And offered a few suggestions to counter the environmental allergies

> and food intolerances.

> My question is: I have Dr G's write-up on why he disagrees on chelation.

> I know he doesn't like secretin, which Dr Layton does use.

> Dr G has explained to us during appts why he doesn't like secretin,

> but I don't think he's ever wrtten anything down like he has with

chelation.

> Any chance of this happening? Dr Layton said a few things about secretin

> and Dr G that we had to correct him on. I'm not sure where he got his

> information - but it wasn't what Dr G told us.

>

> Thanks!

> doris

> -land

>

>

[Guest guest]

Our doctor uses

> pig's secretin from Japan. I know that Dr.Goldberg does not like

secretin

> much , mainly because its animal source, but I think that people

use it for

> long period and there are now negative reports related to " pigs

itself "

I saw Dr.Goldman speak at UCSF yesterday, and what I heard him say

was that the problem with pig derived secretin is that by using it,

you run a hugh risk of becoming unfected with more viral/bacterial

matter. Because the underlying problem of these childre is their

neuro-immune dysfunction, adding more antigens to their system can be

very dangerous. Anyway, that was my take on what he said.

Khris

[Guest guest]

Yes, that was my take on what dr. Goldberg said. I heard him speak in

Sacramento. He said he will not treat those who have been on secretin. I

am new. What is secretin and what does it do?

Gail

khrisday wrote:

>  Our doctor uses

> > pig's secretin from Japan. I know that Dr.Goldberg does not like

> secretin

> > much , mainly because its animal source, but I think that people

> use it for

> > long period and there are now negative reports related to " pigs

> itself "

>  

>

> I saw Dr.Goldman speak at UCSF yesterday, and what I heard him say

> was that the problem with pig derived secretin is that by using it,

> you run a hugh risk of becoming unfected with more viral/bacterial

> matter. Because the underlying problem of these childre is their

> neuro-immune dysfunction, adding more antigens to their system can be

> very dangerous. Anyway, that was my take on what he said.

> Khris

>  

>  

>  

>  

>

>

[Guest guest]

I'll give you the description from the most recent study listed at the

NIH/NICHD. There are " gut-brain " theories of autism that propose a link

between the gastrointestinal disorders observed in many children with autism

and their brain dysfunctions. The theory is different than what you'll find

with most CFS/CFIDS research or . Where the gastro issues are one

effect of the immune dysregulation.

What is interesting is that the research abstract below is related to how

cytokines (inflammation) can reduce secretin. If inflammation is the

problem then it would seem better to address the problems that increase the

inflammatory cytokines throughout the body.

Cheryl

from NICHD publication

Interest in secretin as a possible treatment for autism, a

neurodevelopmental disorder characterized by social and communication

problems and repetitive behaviors and interests, arose from reports of

children with autism whose symptoms improved after receiving a single dose

of the hormone. Secretin is routinely given during tests to diagnose

intestinal ailments, but its safety and effectiveness in treating autism

were not known. Since 1999, more than a half dozen studies examined whether

or not secretin could reduce symptoms in children with autism, with little

evidence of benefit. Varying the doses of the hormone and giving it on more

than one occasion have not proved useful in treating the disorder.

http://www.nichd.nih.gov/new/releases/aut_sec.cfm

Gastroenterology 2001 Jul;121(1):156-69 Related Articles, Books, LinkOut

Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.

Spirli C, son MH, Fiorotto R, Duner E, Denson LA, Sanz JM, Di Virgilio

F, Okolicsanyi L, Casagrande F, Strazzabosco M.

Department of Medical and Surgical Sciences, Clinica Medica I, University of

Padova, Padua, Italy.

BACKGROUND AND AIMS: Cholestatic disorders often are associated with portal

inflammation, but whether or how inflammation contributes to cholestasis is

unknown. Thus we studied the effects of proinflammatory cytokines on bile

duct epithelia secretory mechanisms. METHODS: Isolated bile duct units

(IBDUs) were cultured with interleukin (IL)-6, interferon gamma, tumor

necrosis factor (TNF)-alpha, and IL-1 alone or in combination. Ductular

secretion was measured using video-optical planimetry. Bicarbonate and Cl(-)

transport were assessed microfluorimetric measuring pH(i) (BCECF) and

[Cl(-)](i) transients (MEQ). Expression of Cl(-)/HCO(3)(-) exchanger (AE-2),

cystic fibrosis transmembrane conductance regulator (CFTR), and the secretin

receptor (SR) were assessed by ribonuclease protection assay. Cellular

cyclic adenosine monophosphate (cAMP) levels were studied by enzymatic

immunoassay. Paracellular permeability was assessed using

fluorescein-labeled dextrans (FD) in cholangiocyte monolayers (NRC-1).

RESULTS: Although not effective when given alone, each combination of IL-6,

interferon gamma, IL-1, and TNF-alpha inhibited secretion in IBDU. Cytokines

inhibited cAMP formation, AE-2 activity, and cyclic AMP-dependent Cl(-)

efflux, but not that induced by purinergic agonists. AE-2 gene expression

was unaffected by proinflammatory cytokines, whereas CFTR and SR expression

was increased. In addition, paracellular transit of FD across NRC-1

monolayers was increased. CONCLUSIONS: Inflammatory cytokines inhibit

cAMP-dependent fluid secretion in cholangiocytes and impair the barrier

functions of biliary epithelia. These changes may represent the molecular

mechanisms by which inflammation leads to ductular cholestasis in vivo.

PMID: 11438505 [PubMed - indexed for MEDLINE]

Secretin is a 27-amino acid hormone produced by specific endocrine cells, S

cells, located in the mucosa of the proximal small intestine.

Secretin stimulates ductal bile secretion by directly interacting with

cholangiocytes. It stimulates exocytosis in cholangiocytes, which transport

water mainly via the water channel aquaporin-1 (AQP1; 107776). Marinelli et

al. (1997) tested the hypothesis that secretin promotes osmotic water

movement in cholangiocytes by inducing the exocytic insertion of AQP1 into

plasma membranes. They demonstrated that secretin increases AQP1-mediated

membrane water permeability (Pf) in cholangiocytes. Moreover, they stated

that their studies implicate the microtubule-dependent vesicular

translocation of AQP1 water channels to the plasma membrane, a mechanism

that appears to be essential for secretin-induced ductal bile secretion and

suggests that AQP1 can be regulated by membrane trafficking.

>From: Curtis Mayberry <lmayberr@...>

>Reply-

>

>Subject: Re: Re: secretin

>Date: Mon, 21 Jan 2002 18:47:49 -0800

>

>Yes, that was my take on what dr. Goldberg said. I heard him speak in

>Sacramento. He said he will not treat those who have been on secretin. I

>am new. What is secretin and what does it do?

>Gail

>

>khrisday wrote:

>

> >  Our doctor uses

> > > pig's secretin from Japan. I know that Dr.Goldberg does not like

> > secretin

> > > much , mainly because its animal source, but I think that people

> > use it for

> > > long period and there are now negative reports related to " pigs

> > itself "

> >  

> >

> > I saw Dr.Goldman speak at UCSF yesterday, and what I heard him say

> > was that the problem with pig derived secretin is that by using it,

> > you run a hugh risk of becoming unfected with more viral/bacterial

> > matter. Because the underlying problem of these childre is their

> > neuro-immune dysfunction, adding more antigens to their system can be

> > very dangerous. Anyway, that was my take on what he said.

> > Khris

> >  

> >  

> >  

> >  

> >

> >