Magnesium....a long read but worth it

[Guest guest]

Magnesium See also: Magnesium for Sports & Fitness, Drug interactions What it does Where found Helpful for Are you deficient? Amount to take Side Effects & Interactions References What does it do? Magnesium is an essential mineral to the human body. It is needed for bone, protein, and fatty acid formation, making new cells, activating B vitamins, relaxing muscles, clotting blood, and forming adenosine triphosphate (ATP; the energy the body runs on). The secretion and action of insulin also require magnesium. Magnesium also acts in a way related to calcium channel blocker drugs. This effect may be responsible for the fact that under certain circumstances magnesium has been found to potentially improve vision in people with glaucoma.1 Similarly, this action might account for

magnesium’s ability to lower blood pressure.2 Since magnesium has so many different actions in the body, the exact reasons for some of its clinical effects are difficult to determine. For example, magnesium has reduced hyperactivity in children in preliminary research.3 Other research suggests that some children with attention deficit-hyperactivity disorder (ADHD) have lowered levels of magnesium. In a preliminary but controlled trial, 50 ADHD children with low magnesium (as determined by red blood cell, hair, and serum levels of magnesium) were given 200 mg of magnesium per day for six months.4 Compared with 25 other magnesium-deficient ADHD children, those given magnesium supplementation had a significant decrease in hyperactive behavior. Magnesium levels have been reported to be low in those with chronic fatigue syndrome (CFS),5 and magnesium injections have been reported to improve symptoms.6 Oral magnesium supplementation has also improved symptoms in those people with CFS who had low magnesium levels in another report, although magnesium injections were sometimes necessary.7 However, other research reports no evidence of magnesium deficiency in people with CFS.8 9 The reason for this discrepancy remains unclear. People with CFS considering magnesium supplementation should have their magnesium status checked beforehand by a doctor. Only people with magnesium deficiency appear to benefit from this therapy. People with diabetes tend to have lower magnesium levels compared with those who have normal glucose

tolerance.10 Supplementation with magnesium overcomes this problem11 and may help some diabetics improve glucose tolerance. Magnesium may be beneficial for bladder problems in women, especially common disturbances in bladder control and the sense of "urgency." A double-blind trial found that women who took 350 mg of magnesium hydroxide (providing 147 mg elemental magnesium) twice daily for four weeks had better bladder control and fewer symptoms than women who took a placebo.12 Magnesium supplementation may reduce dehydration of red blood cells in sickle cell anemia patients. Administration of 540 mg per day of magnesium pidolate to sickle cell anemia patients was seen after six months, to reverse some of the characteristic red blood cell abnormalities and to dramatically reduce the number of painful days for these

patients.13 This preliminary trial was not blinded, so placebo effect could not be ruled out. Magnesium pidolate is also an unusual form of magnesium. It is unknown whether other forms of magnesium would produce similar results. Where is it found? Nuts and grains are good sources of magnesium. Beans, dark green vegetables, fish, and meat also contain significant amounts. Magnesium has been used in connection with the following conditions (refer to the individual health concern for complete information): Rating Health Concerns Cardiac arrhythmia Congestive heart failure Diabetes Gestational hypertension Kidney stones (citrate in combination with potassium citrate) Migraine headaches Mitral valve prolapse ADHD Anemia (for thalassemia) Angina Asthma Celiac disease (for

deficiency only) Heart attack (IV magnesium immediately following a myocardial infarction) High blood pressure (for people taking potassium-depleting diuretics) Osteoporosis Premenstrual syndrome Urinary urgency (women) Alcohol withdrawal support Anxiety Athletic performance Autism Chronic fatigue syndrome Chronic obstructive pulmonary disease (COPD) Cluster headache (intravenous) Dysmenorrhea Fibromyalgia Glaucoma Heart attack (oral magnesium) High cholesterol Hypoglycemia Insomnia Insulin resistance syndrome (Syndrome X) Intermittent claudication Multiple sclerosis Preeclampsia Raynaud’s disease Retinopathy Sickle cell anemia Stroke Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no

scientific evidence. For a supplement, little scientific support and/or minimal health benefit. Who is likely to be deficient? Magnesium deficiency is common in people taking “potassium-depleting” prescription diuretics. Taking too many laxatives can also lead to deficiency. Alcoholism, severe burns, diabetes, and heart failure are other potential causes of deficiency. In a study of urban African-American people (predominantly female), the overall prevalence of magnesium deficiency was 20%. People with a history of alcoholism were six times more likely to have magnesium deficiency than were people without such a history.14 The low magnesium status seen in alcoholics with liver cirrhosis contributes to the development of hypertension in these people.15 Almost two-thirds of people in intensive care hospital units have been found to be magnesium deficient.16 Deficiency may also occur in people with chronic diarrhea, pancreatitis, and other conditions associated with malabsorption. Fatigue, abnormal heart rhythms, muscle weakness and spasm, depression, loss of appetite, listlessness, and potassium depletion can all result from a magnesium deficiency. People with these symptoms should be evaluated by a doctor before taking magnesium supplements. As previously mentioned, magnesium levels have been found to be low in people with chronic fatigue syndrome. Deficiencies of magnesium that are serious enough to cause symptoms should be treated by medical doctors, as they might require intravenous administration of magnesium.17 How much is usually taken? Most people don’t consume enough magnesium in their diets. Many nutritionally oriented doctors recommend 250–350 mg per day of supplemental magnesium for adults. Are there any side effects or interactions? Comments in this section are limited to effects from taking oral magnesium. Side effects from intravenous use of magnesium are not discussed. Taking too much magnesium often leads to diarrhea. For some people this can happen with amounts as low as 350–500 mg per day. More serious problems can develop with excessive magnesium intake from magnesium-containing laxatives. However, the amounts of magnesium found in nutritional supplements are unlikely to cause such problems. People with kidney disease should not take magnesium supplements without consulting a doctor. Vitamin B6 increases the amount of magnesium that can enter cells. As a result, these two nutrients are often taken together. Magnesium may compete for absorption with other minerals, particularly calcium. Taking a multimineral supplement avoids this

potential problem. Are there any drug interactions?Certain medicines may interact with magnesium. Refer to drug interactions for a list of those medicines. References 1. Gaspar AZ, Gasser P, Flammer J. The influence of magnesium on visual field and peripheral vasospasm in glaucoma. Ophthalmologica 1995;209:11–3. 2. Kawano Y, Matsuoka H, Takishita S, Omae T. Effects of magnesium supplementation in hypertensive patients. Hypertension 1998;32:260–5. 3. Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit

hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997;10:149–56. 4. Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997;10:149–56. 5. Moorkens G, y Keenoy B, Vertommen J, et al. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res 1997;10:329–37. 6. IM, MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991;337:757–60. 7. JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome. Lancet 1992;340:426. 8. Gantz NM. Magnesium and chronic fatigue. Lancet

1991;338:66 [letter]. 9. Hinds G, Bell NP, McMaster D, McCluskey DR. Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome. Ann Clin Biochem 1994;31(Pt 5):459–61. 10. Paolisso G, Scheen A, D’Onofrio FD, Lefebvre P. Magnesium and glucose homeostasis. Diabetologia 1990;33:511–4 [review]. 11. Eibl NL, Schnack CJ, Kopp H-P, et al. Hypomagnesemia in type II diabetes: effect of a 3-month replacement therapy. Diabetes Care 1995;18:188. 12. Gordon D, Groutz A, Ascher-Landsberg J, et al. Double-blind, placebo-controlled study of magnesium hydroxide for treatment of sensory urgency and detrusor instability: preliminary results. Br J Obstet Gynaecol 1998;105:667–9. 13. De Franceschi L, Bachir D, Galacteros F, et al. Oral magnesium pidolate: effects of

long-term administration in patients with sickle cell disease. Br J Haematol 2000 Feb;108:284–9. 14. Fox CH, Ramsoomair D, Mahoney MC, et al. An investigation of hypomagnesemia among ambulatory urban African Americans. J Fam Pract 1999;48:636–9. 15. Kisters K, Schodjaian K, Tokmak F, et al. Effect of ethanol on blood pressure—role of magnesium. Am J Hypertens 2000;13:455–6 [letter]. 16. Weisinger JR, Bellorin-font E. Magnesium and phosphorus.Lancet 1998;352:391–6 [review]. 17. Weisinger JR, Bellorin-font E. Magnesium and phosphorus.Lancet 1998;352:391–6 [review]. God is so big He can cover the whole world with

his Love and so small He can curl up inside your heart. June Masters Bacher