Decreased pancreatic digestive enzymes during aflatoxicosis

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1: Poult Sci. 1981 Aug;60:1818-21.

Decreased pancreatic digestive enzymes during aflatoxicosis

Osborne DJ, Hamilton PB.

Dietary aflatoxin at concentrations of 1.25 microgram/g or above

caused in broiler chickens a significant (P less than .05) decrease

in the specific activities of pancreatic amylase, trypsin, lipase,

RNase, and DNase. These enzymes are the primary enzymes of digestion

for starches, protein, lipid, and nucleic acids. At concentrations

of 2.5 microgram/g or above there was a compensatory pancreatomegaly

that resulted in essentially normal total activity for trypsin,

RNase, and DNase. Thus, aflatoxicosis was associated with reduced

activity levels of enzymes that digest starch and lipid. This

digestive deficiency could account for a malabsorption syndrome

observed in field outbreaks of aflatoxicosis.

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