Metabolism of mycotoxins, intracellular functions of vitamin B12, and neurologic

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1: ScientificWorldJournal. 2004 Aug 26;4:736-45.

Metabolism of mycotoxins, intracellular functions of vitamin B12,

and neurological manifestations in patients with chronic toxigenic

mold exposures. A review.

Anyanwu EC, Morad M, AW.

This paper evaluates the possible reasons for consistent vitamin B12

deficiency in chronic toxigenic mold exposures and the synergistic

relationships with the possible mycotoxic effects on one-carbon

metabolism that lead to the manifestations of clinical

neuropathological symptomology. Vitamins are first defined in

general and the nutritional sources of vitamin B12 are evaluated in

particular. Since patients with chronic exposures to toxigenic molds

manifest vitamin B12 deficiencies, the role of mycotoxins in vitamin

B12 metabolism is assessed, and since vitamin B12 plays important

biochemical roles in one-carbon metabolism, the synergistic effects

with mycotoxins on humans are reviewed. An outline of the proposed

mechanism by which mycotoxins disrupt or interfere with the normal

functions of vitamin B12 on one-carbon metabolism is proposed. The

overall functions of vitamin B12 as a source of coenzymes, in

intracellular recycling of methionine, in methionine synthase

reaction, in the prevention of chromosome breakage, in methylation,

and in maintaining a one-carbon metabolic balance are reviewed.

Signs, symptoms, and clinical neurological indications of vitamin

B12 deficiency are also cited. By implication and derivation, it is

likely that the interruption of the structure and function of

vitamin B12 would in turn interfere with the one-carbon metabolism

leading to the neurological manifestations. This review is an

attempt to formulate a basis for an ongoing research investigation

on the subject.

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