Aspergillosis presenting as an optic neuritis.

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1: Korean J Ophthalmol. 2002 Dec;16(2):119-23. Related Articles,

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Aspergillosis presenting as an optic neuritis.

Choi MY, Bae IH, Lee JH, Lee SJ.

Department of Ophthalmology, College of Medicine, Chungbuk National

University & Chungbuk National University Medical Research

Institute, Cheongju, Korea.

A 59-year-old woman was referred to our clinic with sudden visual

loss in her right eye after she was treated with 40 mg/day of oral

prednisolone for 2 weeks under the diagnosis of idiopathic optic

neuritis. At that time, computerized tomography (CT) of the brain

showed no evidence of optic nerve or brain pathology. However, there

was progressive diminution of right visual acuity associated with a

limitation of adduction and abduction in the right eye. On magnetic

resonance imaging and repeated CT, a malignant lesion was suggested,

and was confirmed as an Aspergillus fungus colony by histopathologic

examination. Postoperatively, she was treated with intravenous

administration of amphotericin B for 13 weeks. However, her

condition continued to deteriorate. She developed ptosis and total

ophthalmoplegia in the right eye and blindness in both eyes. After

discharge, she was given itraconazole for 20 weeks. She has shown no

recovery of visual acuity or extraocular motion during a two-year

follow-up period. The clinical features of our case suggest that

early diagnosis in a case of aspergilloma presenting with visual

loss is difficult and that a high index of suspicion, repeated

radiological examination and adequate biopsy may be required for

diagnosis.

Publication Types:

Case Reports

PMID: 12546451 [PubMed - indexed for MEDLINE]