Prevalence of aspergillosis in bronchogenic carcinoma

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1: Indian J Pathol Microbiol. 2003 Jul;46(3):507-10. Related

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Prevalence of aspergillosis in bronchogenic carcinoma.

Malik A, Shahid M, Bhargava R.

Department of Microbiology, J.N. Medical College, Aligarh Muslim

University, Aligarh. abidamalik2k@...

Bronchoalveolar lavage of 42 patients of bronchogenic carcinoma was

studied to find out the prevalence of aspergillosis. Sera of the

patients were also analysed for presence of anti-Aspergillus

antibodies by Immunodiffusion (ID), Enzyme linked immunosorbent

assay (ELISA) and dot blot assay (DBA). Aspergillus was isolated in

culture from 6 (14.2%) patients of bronchogenic carcinoma.

Aspergillus fumigatus was the predominant species isolated. All the

strains of Aspergillus were sensitive to itraconazole, ketoconazole

and amphotericin B while resistance (33.3%) was found with

fluconazole. Anti-aspergillus antibodies were detected equally by

ID, ELISA and DBA in 9 (21.4%) cases. The present study revealed

prevalence and seroprevalance of Aspergillus in bronchogenic

carcinoma to be 14.2% and 21.4% respectively. Consistent reactivity

against 18 kDa Aspergillus fumigatus antigen was noted in

serologically positive cases. Antibodies against 18 kDa protein

antigen in western blotting may be used as a reference marker for

diagnosis of aspergillosis in bronchogenic carcinoma. It is also

suggested that the simplest serological technique like ID may be

performed along with culture for diagnosing Aspergillosis in

patients of bronchogenic carcinoma since ID, ELISA and DBA showed

similar sensitivity.

PMID: 15025326 [PubMed - indexed for MEDLINE]