Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's

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The Journal of Nutritional Biochemistry

Volume 15, Issue 9 , September 2004, Pages 506-516

doi:10.1016/j.jnutbio.2004.05.002

Copyright © 2004 Elsevier Inc. All rights reserved.

Review: Current topic

Neurological mechanisms of green tea polyphenols in Alzheimer's and

Parkinson's diseases

Orly Weinreba, Silvia Mandela, Tamar Amita and Moussa B. H.

Youdim, , a

a Eve Topf and USA National Parkinson Foundation Centers of

Excellence for Neurodegenerative Diseases Research and Department of

Pharmacology, Rappaport Family Research Institute, Technion-Faculty

of Medicine, 31096, Haifa, Israel

Received 8 March 2004; Revised 10 May 2004; accepted 26 May 2004.

Available online 9 September 2004.

Abstract

Tea consumption is varying its status from a mere ancient beverage

and a lifestyle habit, to a nutrient endowed with possible

prospective neurobiological–pharmacological actions beneficial to

human health. Accumulating evidence suggest that oxidative stress

resulting in reactive oxygen species generation and inflammation

play a pivotal role in neurodegenerative diseases, supporting the

implementation of radical scavengers, transition metal (e.g., iron

and copper) chelators, and nonvitamin natural antioxidant

polyphenols in the clinic. These observations are in line with the

current view that polyphenolic dietary supplementation may have an

impact on cognitive deficits in individuals of advanced age. As a

consequence, green tea polyphenols are now being considered as

therapeutic agents in well controlled epidemiological studies, aimed

to alter brain aging processes and to serve as possible

neuroprotective agents in progressive neurodegenerative disorders

such as Parkinson's and Alzheimer's diseases. In particular,

literature on the putative novel neuroprotective mechanism of the

major green tea polyphenol, ( & #8722;)-epigallocatechin-3-gallate, are

examined and discussed in this review.

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