Re: Exposure to formaldehyde, abstracts - SBS - MCS,Japan 2004 + Effect of exposure to volatile organic compounds on plasma levels of....

[Guest guest]

\

Thanks for this article.

I think it should be swent to every person who graduated form SW College

of NAturopathic MEdicine in Tempe to show what they have to look forward

to.

Actually, I think I am going to print htis out ande send it to

Cronin, ND who is the president of Gaia Herbs who informed me that the

cadavers are SAFE and so was the air in the med school that injured me.

Angel

On Mon, 11 Oct 2004 520020231544-0001@... wrote:

> Date: 11 Oct 2004 08:09 GMT

> From: 520020231544-0001@...

> Reply-

>

> Subject: [] Exposure to formaldehyde, abstracts - SBS - MCS,

> Japan 2004 + Effect of exposure to volatile organic compounds on plasma

> levels of....

\

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15471282

>

> 1: J UOEH. 2004 Sep 1;26(3):337-48.

> Related Articles,Links

>

> [Exposure to formaldehyde during an anatomy dissecting course]

>

> [Article in Japanese]

>

> Kunugita N, Nakashima T, Kikuta A, Kawamoto T, Arashidani K.

>

> Department of Health Information Science, School of Health Sciences,

> University of Occupational and Environmental

> Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

>

> Formaldehyde is a flammable, colorless and readily polymerized gas at

> ambient temperature, and is one of the major

> pollutants in indoor air. Medical students during their dissection course

> are exposed to formaldehyde, whose exposure is

> recently considered to be one of the causes of multiple chemical

> sensitivity. To understand the system that produces

> exposures and to plan for implementing control options, this study

> examined formaldehyde exposures that occurred in the

> gross anatomy laboratory. Formaldehyde in air was sampled by an active

> 2,4-dinitrophenylhydrazine (DNPH)-silica gel

> cartridge, extracted with acetonitrile and analyzed with an high

> performance liquid chromatograph-ultraviolet(HPLC-

> UV)detector. The geometric mean formaldehyde concentration was 20-93 ppb

> in the anatomy laboratory before starting the

> anatomy dissecting. After beginning the dissecting, however, the highest

> geometric mean concentrations were 1012- 1380

> ppb. Significant differences were observed during the exposed period for

> symptoms of " unusual thirst " , " burning eyes " ,

> " itchy eyes " , " bad feeling " , " fatigue " , etc. in comparison with the

> non-exposed period. These results show that medical

> schools should take more concrete measures to reduce exposure to

> formaldehyde.

>

> PMID: 15471282 [PubMed - in process]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15196973

>

> 1: Brain Res. 2004 Jul 2;1013(1):107-16.

> Related Articles,Links

>

> Effect of prolonged exposure to low concentrations of formaldehyde on the

> corticotropin releasing hormone neurons in the

> hypothalamus and adrenocorticotropic hormone cells in the pituitary gland

> in female mice.

>

> Sari DK, Kuwahara S, Tsukamoto Y, Hori H, Kunugita N, Arashidani K,

> Fujimaki H, Sasaki F.

>

> Laboratory of Veterinary Anatomy, Graduate School of Agriculture and

> Biological Sciences, Osaka Prefecture University,

> Gakuen-cho 1-1, Sakai, Osaka, 599-8531 Japan.

>

> We examine the effect on the hypothalamus-pituitary-adrenal gland (HPA)

> axis of prolonged exposure to low levels of

> formaldehyde in female C3H/He mice, using immunocytochemical and RT-PCR

> methods. Two groups of female mice were exposed

> to differing concentrations (0, 80, 400, 2000 ppb) of formaldehyde

> inhalation for 16 h/day, 5 days/week, for 12 weeks.

> The corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons in

> the hypothalamus were then examined, together

> with the adrenocorticotropin hormone (ACTH)-ir cells and ACTH mRNA in the

> pituitary. One group comprised sham control

> mice. The other group was made allergic by injection of ovalbumin (OVA)

> and alum prior to exposure to formaldehyde,

> since most sick building syndrome (SBS) sufferers are women with allergic

> disease. These animals were further exposed to

> aerosolized OVA as a booster four times during the exposure period. Our

> results showed a dose- dependent increase in the

> number of CRH-ir neurons in the non-allergy (NAG) group. A similar

> pattern was found in ACTH-ir cells and ACTH mRNA. The

> allergy (AG) model group showed an increase in basal levels of all

> markers of HPA activity. Moreover, the AG mice

> appeared to respond to the lowest concentration of formaldehyde, and all

> indices of HPA activity were reduced at the

> highest concentrations of formaldehyde. These results relate to an

> important clinical issue and also have implications

> in the broader area of HPA regulation. We conclude that our experimental

> system may be a suitable animal model for SBS

> and/or multiple chemical sensitivity (MCS).

>

> PMID: 15196973 [PubMed - indexed for MEDLINE]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15064152

>

> 1: Brain Res. 2004 May 8;1007(1-2):192-7.

> Related Articles,Links

>

> Long-term exposure to low levels of formaldehyde increases the number of

> tyrosine hydroxylase-immunopositive

> periglomerular cells in mouse main olfactory bulb.

>

> Hayashi H, Kunugita N, Arashidani K, Fujimaki H, Ichikawa M.

>

> Laboratory of Cell Biology and Anatomy, Department of Basic Techniques

> and Facilities, Tokyo Metropolitan Institute for

> Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2-6,

> Musashidai, Fuchu City, Tokyo 183-8526, Japan.

>

> Multiple chemical sensitivity (MCS) in response to a long-term low-level

> chemical exposure is as yet an unclarified

> disorder. To determine the role of olfactory function in the induction of

> MCS, immunocytochemical analysis of the main

> olfactory bulb (MOB) was performed after exposure of mice to low levels

> of formaldehyde. A long-term exposure resulted

> in an increase in the number of tyrosine hydroxylase-immunopositive

> periglomerular cells and may affect the neuronal

> function of the MOB.

>

> PMID: 15064152 [PubMed - indexed for MEDLINE]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15031958

>

> 1: Int J Hyg Environ Health. 2004 Feb;207(2):159-63.

> Related Articles,Links

>

> Effect of exposure to volatile organic compounds on plasma levels of

> neuropeptides, nerve growth factor and histamine in

> patients with self-reported multiple chemical sensitivity.

>

> Kimata H.

>

> Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Uji-City,

> Kyoto Prefecture, 611-0021, Japan.

> unitikah@...

>

> Plasma levels of substance P, vasoactive intestinal peptide and nerve

> growth factor, but not histamine, were elevated in

> patients with self-reported multiple chemical sensitivity (sMCS).

> Exposure to volatile organic compounds (VOC) increased

> plasma levels of all parameters in these patients, while it had no effect

> in normal subjects or patients with atopic

> eczema/ dermatitis syndrome (AEDS). Exposure to VOC also enhanced skin

> wheal responses induced by histamine in patients

> with sMCS, while it failed to do so in normal or AEDS subjects. These

> results indicate that exposure to VOC may enhance

> neurogenic inflammation with concomitant enhancement of histamine-induced

> responses.

>

> PMID: 15031958 [PubMed - indexed for MEDLINE]

>

>

>

>

>

>

>

>

>

>

>

> FAIR USE NOTICE:

>

> This site contains copyrighted material the use of which has not always

> been specifically authorized by the copyright owner. We are making such

> material available in our efforts to advance understanding of

> environmental, political, human rights, economic, democracy, scientific,

> and social justice issues, etc. We believe this constitutes a 'fair use'

> of any such copyrighted material as provided for in section 107 of the US

> Copyright Law. In accordance with Title 17 U.S.C. Section 107, the

> material on this site is distributed without profit to those who have

> expressed a prior interest in receiving the included information for

> research and educational purposes. For more information go to:

> http://www.law.cornell.edu/uscode/17/107.shtml. If you wish to use

> copyrighted material from this site for purposes of your own that go

> beyond 'fair use', you must obtain permission from the copyright owner.

>

>

>

[Guest guest]

\

Thanks for this article.

I think it should be swent to every person who graduated form SW College

of NAturopathic MEdicine in Tempe to show what they have to look forward

to.

Actually, I think I am going to print htis out ande send it to

Cronin, ND who is the president of Gaia Herbs who informed me that the

cadavers are SAFE and so was the air in the med school that injured me.

Angel

On Mon, 11 Oct 2004 520020231544-0001@... wrote:

> Date: 11 Oct 2004 08:09 GMT

> From: 520020231544-0001@...

> Reply-

>

> Subject: [] Exposure to formaldehyde, abstracts - SBS - MCS,

> Japan 2004 + Effect of exposure to volatile organic compounds on plasma

> levels of....

\

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15471282

>

> 1: J UOEH. 2004 Sep 1;26(3):337-48.

> Related Articles,Links

>

> [Exposure to formaldehyde during an anatomy dissecting course]

>

> [Article in Japanese]

>

> Kunugita N, Nakashima T, Kikuta A, Kawamoto T, Arashidani K.

>

> Department of Health Information Science, School of Health Sciences,

> University of Occupational and Environmental

> Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

>

> Formaldehyde is a flammable, colorless and readily polymerized gas at

> ambient temperature, and is one of the major

> pollutants in indoor air. Medical students during their dissection course

> are exposed to formaldehyde, whose exposure is

> recently considered to be one of the causes of multiple chemical

> sensitivity. To understand the system that produces

> exposures and to plan for implementing control options, this study

> examined formaldehyde exposures that occurred in the

> gross anatomy laboratory. Formaldehyde in air was sampled by an active

> 2,4-dinitrophenylhydrazine (DNPH)-silica gel

> cartridge, extracted with acetonitrile and analyzed with an high

> performance liquid chromatograph-ultraviolet(HPLC-

> UV)detector. The geometric mean formaldehyde concentration was 20-93 ppb

> in the anatomy laboratory before starting the

> anatomy dissecting. After beginning the dissecting, however, the highest

> geometric mean concentrations were 1012- 1380

> ppb. Significant differences were observed during the exposed period for

> symptoms of " unusual thirst " , " burning eyes " ,

> " itchy eyes " , " bad feeling " , " fatigue " , etc. in comparison with the

> non-exposed period. These results show that medical

> schools should take more concrete measures to reduce exposure to

> formaldehyde.

>

> PMID: 15471282 [PubMed - in process]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15196973

>

> 1: Brain Res. 2004 Jul 2;1013(1):107-16.

> Related Articles,Links

>

> Effect of prolonged exposure to low concentrations of formaldehyde on the

> corticotropin releasing hormone neurons in the

> hypothalamus and adrenocorticotropic hormone cells in the pituitary gland

> in female mice.

>

> Sari DK, Kuwahara S, Tsukamoto Y, Hori H, Kunugita N, Arashidani K,

> Fujimaki H, Sasaki F.

>

> Laboratory of Veterinary Anatomy, Graduate School of Agriculture and

> Biological Sciences, Osaka Prefecture University,

> Gakuen-cho 1-1, Sakai, Osaka, 599-8531 Japan.

>

> We examine the effect on the hypothalamus-pituitary-adrenal gland (HPA)

> axis of prolonged exposure to low levels of

> formaldehyde in female C3H/He mice, using immunocytochemical and RT-PCR

> methods. Two groups of female mice were exposed

> to differing concentrations (0, 80, 400, 2000 ppb) of formaldehyde

> inhalation for 16 h/day, 5 days/week, for 12 weeks.

> The corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons in

> the hypothalamus were then examined, together

> with the adrenocorticotropin hormone (ACTH)-ir cells and ACTH mRNA in the

> pituitary. One group comprised sham control

> mice. The other group was made allergic by injection of ovalbumin (OVA)

> and alum prior to exposure to formaldehyde,

> since most sick building syndrome (SBS) sufferers are women with allergic

> disease. These animals were further exposed to

> aerosolized OVA as a booster four times during the exposure period. Our

> results showed a dose- dependent increase in the

> number of CRH-ir neurons in the non-allergy (NAG) group. A similar

> pattern was found in ACTH-ir cells and ACTH mRNA. The

> allergy (AG) model group showed an increase in basal levels of all

> markers of HPA activity. Moreover, the AG mice

> appeared to respond to the lowest concentration of formaldehyde, and all

> indices of HPA activity were reduced at the

> highest concentrations of formaldehyde. These results relate to an

> important clinical issue and also have implications

> in the broader area of HPA regulation. We conclude that our experimental

> system may be a suitable animal model for SBS

> and/or multiple chemical sensitivity (MCS).

>

> PMID: 15196973 [PubMed - indexed for MEDLINE]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15064152

>

> 1: Brain Res. 2004 May 8;1007(1-2):192-7.

> Related Articles,Links

>

> Long-term exposure to low levels of formaldehyde increases the number of

> tyrosine hydroxylase-immunopositive

> periglomerular cells in mouse main olfactory bulb.

>

> Hayashi H, Kunugita N, Arashidani K, Fujimaki H, Ichikawa M.

>

> Laboratory of Cell Biology and Anatomy, Department of Basic Techniques

> and Facilities, Tokyo Metropolitan Institute for

> Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2-6,

> Musashidai, Fuchu City, Tokyo 183-8526, Japan.

>

> Multiple chemical sensitivity (MCS) in response to a long-term low-level

> chemical exposure is as yet an unclarified

> disorder. To determine the role of olfactory function in the induction of

> MCS, immunocytochemical analysis of the main

> olfactory bulb (MOB) was performed after exposure of mice to low levels

> of formaldehyde. A long-term exposure resulted

> in an increase in the number of tyrosine hydroxylase-immunopositive

> periglomerular cells and may affect the neuronal

> function of the MOB.

>

> PMID: 15064152 [PubMed - indexed for MEDLINE]

>

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra

> ct & list_uids=15031958

>

> 1: Int J Hyg Environ Health. 2004 Feb;207(2):159-63.

> Related Articles,Links

>

> Effect of exposure to volatile organic compounds on plasma levels of

> neuropeptides, nerve growth factor and histamine in

> patients with self-reported multiple chemical sensitivity.

>

> Kimata H.

>

> Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Uji-City,

> Kyoto Prefecture, 611-0021, Japan.

> unitikah@...

>

> Plasma levels of substance P, vasoactive intestinal peptide and nerve

> growth factor, but not histamine, were elevated in

> patients with self-reported multiple chemical sensitivity (sMCS).

> Exposure to volatile organic compounds (VOC) increased

> plasma levels of all parameters in these patients, while it had no effect

> in normal subjects or patients with atopic

> eczema/ dermatitis syndrome (AEDS). Exposure to VOC also enhanced skin

> wheal responses induced by histamine in patients

> with sMCS, while it failed to do so in normal or AEDS subjects. These

> results indicate that exposure to VOC may enhance

> neurogenic inflammation with concomitant enhancement of histamine-induced

> responses.

>

> PMID: 15031958 [PubMed - indexed for MEDLINE]

>

>

>

>

>

>

>

>

>

>

>

> FAIR USE NOTICE:

>

> This site contains copyrighted material the use of which has not always

> been specifically authorized by the copyright owner. We are making such

> material available in our efforts to advance understanding of

> environmental, political, human rights, economic, democracy, scientific,

> and social justice issues, etc. We believe this constitutes a 'fair use'

> of any such copyrighted material as provided for in section 107 of the US

> Copyright Law. In accordance with Title 17 U.S.C. Section 107, the

> material on this site is distributed without profit to those who have

> expressed a prior interest in receiving the included information for

> research and educational purposes. For more information go to:

> http://www.law.cornell.edu/uscode/17/107.shtml. If you wish to use

> copyrighted material from this site for purposes of your own that go

> beyond 'fair use', you must obtain permission from the copyright owner.

>

>

>