CT and MR findings of brain aspergillosis

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Computerized Medical Imaging and Graphics

Volume 27, Issue 6 , November-December 2003, Pages 489-492

doi:10.1016/S0895-6111(03)00033-8

Copyright © 2003 Elsevier Ltd. All rights reserved.

Short communication

CT and MR findings of brain aspergillosis

Takashi Okafuji, , a, Hidetake Yabuuchia, Yoshihisa Nagatoshib,

Youichi Hattandac and Tatsuro Fukuyad

a Department of Radiology, National Kyushu Cancer Center, 3-1-1

Notame, Minami-ku, Fukuoka 811-1395, Japan

b Department of Pediatrics, National Kyushu Cancer Center, 3-1-1

Notame, Minami-ku, Fukuoka 811-1395, Japan

c Department of Pathology, National Kyushu Cancer Center, 3-1-1

Notame, Minami-ku, Fukuoka 811-1395, Japan

d Department of Radiology, National Oita Hospital, 2-11-45 Yokota,

Oita 870-0263, Japan

Received 20 August 2002; accepted 11 February 2003. ; Available

online 17 May 2003.

Abstract

CT and MR findings of a case of brain aspergillosis with

histopathologic correlation are reported. On both CT and MR images,

there were multiple lesions in the corticomedullary junction (CMJ)

that appeared to disrupt the cortical sulci and that were not

enhanced by intravenous contrast material. In most of these lesions,

there were centrally located structures that were enhanced by

intravenous contrast material and that appeared to be continuous

from markedly enhanced adjacent dilated cortical vessels.

Histopathologic examination of the autopsy specimen showed multiple

hemorrhagic infarcts in the CMJ with remaining dilated cortical

vessels that had been thrombosed by aspergillus hyphae.

Author Keywords: Aspergillosis; Immunocompromised; Brain, CT; Brain,

MR

Corresponding author. Address: Department of Clinical Radiology,

Graduate School of Medical Sciences, Kyushu University, 3-1-1

Maidashi, Higash-ku, Fukuoka 812-8582, Japan. Tel.: +81-92-642-5695;

fax: +81-92-642-5708