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Rhinocerebral mucormycosis with cerebral extension successfully treated with

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=3382536

1: Arch Otolaryngol Head Neck Surg. 1988 Jul;114(7):791-4.

Rhinocerebral mucormycosis with cerebral extension successfully

treated with adjunctive hyperbaric oxygen therapy.

Couch L, Theilen F, Mader JT.

Department of Internal Medicine, University of Texas Medical Branch,

Galveston 77550-2772.

Rhinocerebral mucormycosis is a devastating fungal disease with a

high mortality rate. Extensive surgical debridement and amphotericin

B are currently the mainstays of therapy. When cerebral extension of

the fungus occurs, the disease is almost invariably fatal. Two

patients with rhinocerebral mucormycosis had progression of their

infection to brain abscesses despite aggressive debridement surgery

and amphotericin B therapy. Both patients showed marked clinical

improvement with the addition of adjunctive hyperbaric oxygen

therapy. Both patients remained free of their disease 21 months

after hospital discharge.

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