Comparison of the Prevention of Aflatoxin B1-Induced Genotoxicity by Quercetin

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Bioorganic & Medicinal Chemistry Letters

Volume 12, Issue 18 , 16 September 2002, Pages 2579-2582

doi:10.1016/S0960-894X(02)00478-X

Copyright © 2002 Elsevier Science Ltd. All rights reserved.

Comparison of the Prevention of Aflatoxin B1-Induced Genotoxicity by

Quercetin and Quercetin Pentaacetate

Ekta Kohlia, Hanumantharao G. Raja, Ranju Kumaria, Vishwajit Rohila,

Narendra K. Kaushikb, Ashok K. Prasadb and Virinder S. Parmar, , b

a Department of Biochemistry, V. P. Chest Institute, University of

Delhi, Delhi-110 007, India

b Bioorganic Laboratory, Department of Chemistry, University of

Delhi, Delhi-110 007, India

Received 22 October 2001; accepted 20 June 2002. Available online

15 August 2002.

Abstract

Earlier work carried out in our laboratory highlighted the mode of

action of acetoxy 4-methylcoumarins in preventing the genotoxicity

of aflatoxin B1 (AFB1). We have in this report extended the

observations to quercetin pentaacetate (QPA), which unlike quercetin

(Q) has demonstrated time-dependent inhibition of liver microsome

catalysed AFB1 epoxidation as measured by AFB1 binding to DNA. The

action of QPA is similar to that of the acetoxy 4-methylcoumarins in

that they are acted upon by microsomal transacetylase leading to

modulation of catalytic activities of certain enzymes (such as P-450

enzymes, NADPH cytochrome C reductase and glutathione S-transferase)

possibly by way of protein acetylation. In the present work, we have

documented the transacetylase-mediated action of QPA in preventing

genotoxicity due to AFB1.

Graphical Abstract

Quercetin penta acetate (QPA) unlike quercetin demonstrated time-

dependent inhibition of liver microsome-catalyzed AFB1 epoxidation

as measured by AFB1 binding to DNA. In the present work, we have

demonstrated the transacetylase-mediated action of QPA in the

prevention of genotoxicity due to AFB1.

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