Long term effect of aflatoxin B1 on lipid peroxidation in rat liver and kidney:

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http://www3.interscience.wiley.com/cgi-bin/abstract/81002356/ABSTRACT

Phytotherapy Research

Volume 15, Issue 4 , Pages 307 - 310

Published Online: 15 May 2001

Copyright © 2001 Wiley & Sons, Ltd.

Research Article

Long term effect of aflatoxin B1 on lipid peroxidation in rat liver

and kidney: effect of picroliv and silymarin

Ravi Rastogi, Arvind Kumar Srivastava *, Anil Kumar Rastogi

Division of Biochemistry, Central Drug Research Institute, Lucknow-

226 001, India

*Correspondence to Arvind Kumar Srivastava, Biochemistry Division,

Central Drug Research Institute, Lucknow 226 001, India

CDRI Communication No. 5992

Keywords

aflatoxin-B1; picroliv; silymarin; Picrorhiza kurroa

Abstract

Aflatoxin B1 (AFB1) is a potent hepatotoxic and hepatocarcinogenic

mycotoxin. The mechanism of cellular damage caused by AFB1 has not

been fully elucidated. Lipid peroxidation is one of the main

manifestations of oxidative damage and has been found to play an

important role in the toxicity and carcinogenesis of many

carcinogens. The present investigation aims at assessing the

comparative antioxidant effet of picroliv, a standardized iridoid

glycoside fraction of Picrorhiza kurroa and silymarin, a well known

standard hepatoprotective, on aflatoxin B1 induced lipid-

peroxidation in rat liver and kidney. Marked increases in lipid

peroxide levels and a concomitant decrease in enzymic antioxidant

levels were observed in aflatoxin B1 (2 mg/kg, i.p) -toxicated rats,

while drug (picroliv and silymarin both) treatment reversed the

condition to near normal levels. The effects of picroliv and

silymarin were comparable. Copyright © 2001 Wiley & Sons, Ltd.

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