Tremorgenic mycotoxicosis in four dogs from a single household

[Guest guest]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=12458614

1: J Am Vet Med Assoc. 2002 Nov 15;221(10):1441-4, 1420.

Tremorgenic mycotoxicosis in four dogs from a single household

Boysen SR, Rozanski EA, Chan DL, Grobe TL, Fallon MJ, Rush JE.

Department of Clinical Sciences, School of Veterinary Medicine,

Tufts University, North Grafton, MA 01536, USA.

Mycotoxins are fungal metabolites that induce undesirable effects.

The effects of these mycotoxins vary depending on the chemical

structure of the toxin and degree of toxicity. Mycotoxins that

induce muscle tremors, ataxia, and convulsions are termed

tremorgenic mycotoxins. Our report documents the clinical course of

4 dogs from a single household that were simultaneously affected by

tremorgenic mycotoxins. Diagnosis of tremorgenic mycotoxicosis was

confirmed by stomach content analysis from 1 of the dogs. The

mycotoxins identified were penitrem A and roquefortine, which are

both produced by Penicillium spp. Treatment goals following

tremorgenic mycotoxin ingestion include minimizing absorption,

controlling tremors and seizures with methocarbamol and

pentobarbital sodium administration, and providing supportive care.

Two of the affected dogs required ventilatory support. With early

aggressive treatment, prognosis is good and recovery is complete

without sequelae. It is helpful for the clinician to be familiar

with the typical clinical signs at the time of admission, treatment,

and clinical course of dogs with tremorgenic mycotoxicosis.

FAIR USE NOTICE:

This site contains copyrighted material the use of which has not

always been

specifically authorized by the copyright owner. We are making such

material

available in our efforts to advance understanding of environmental,

political, human rights, economic, democracy, scientific, and social

justice

issues, etc. We believe this constitutes a 'fair use' of any such

copyrighted material as provided for in section 107 of the US

Copyright Law.

In accordance with Title 17 U.S.C. Section 107, the material on this

site is

distributed without profit to those who have expressed a prior

interest in

receiving the included information for research and educational

purposes.

For more information go to:

http://www4.law.cornell.edu/uscode/17/107.html

If you wish to use copyrighted material from this

site for purposes of your

own that go beyond 'fair use', you must obtain permission from the

copyright

owner.