Treatment of late onset autism as a consequence of probable autommune processes

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1: World J Biol Psychiatry. 2002 Jul;3(3):162-6.

Treatment of late onset autism as a consequence of probable

autommune processes related to chronic bacterial infection.

Matarazzo EB.

Department of Psychiatry, School of Medicine, University of Sao

o, Brazil. eneidam_br@...

Two cases are described of children who at first developed normally,

but before the age of three developed autistic symptoms following

the reactivation of a chronic oto-rhinolaryngologic infection. The

clinical and laboratory data of the cases support the aetiological

hypothesis of an autoimmune process. Adrenocorticotrophic hormone

(ACTH), prescribed in the first months of the disease, cured one

case. The other patient, who was two years old when autistic

symptoms appeared and was treated only six years later, showed a

partial but definitive improvement with the immunosuppressive

treatment. This report proposes that reactivation of a chronic

bacterial infection be included among the aetiologies of Late Onset

Autism, and demonstrates that, when the aetiological hypothesis of

an autoimmune process based on clinical and laboratory data is

considered, an immunosuppressive treatment, particularly with ACTH,

can be very effective and also safe.

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