Influence of ochratoxin A and an extract of artichoke on the vaccinal immunity

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1: Exp Toxicol Pathol. 2000 Mar;52(1):43-55.

Influence of ochratoxin A and an extract of artichoke on the

vaccinal immunity and health in broiler chicks.

Stoev SD, Anguelov G, Ivanov I, Pavlov D.

Department of Pathomorphology, Faculty of Veterinary Medicine,

Thracian University Stara Zagora, Bulgaria.

s_stoev@...

The combined effect of ochratoxin A (at diet levels of 130, 305 and

790 ppb) and penicillic acid was studied in 100 broiler chicks.

Serological investigations revealed significantly lower

haemagglutination inhibiting antibody titers in the experimental

chicks immunized with vaccine against Newcastle disease. A

statistically significant decrease of the body weight and the

relative weight of lymphoid organs as well as a significant increase

of the relative weight of kidneys and liver were seen. The main

degenerative changes were observed in the proximal convoluted

tubules in kidneys and slight degenerative changes were found in the

hepatocytes. Degenerative changes and depletion of lymphoid cells

were observed in the bursa Fabricii, thymus, spleen and Peyer's

patches of intestinal mucosa. Serum analyses revealed significant

decreases of the total protein and cholesterol, and significant

increases of the uric acid and glucose. Haematological analyses

showed a slight anaemia, leucocytosis and slightly decompensated

metabolic acidosis. A statistically significant protective effect of

5% total water extract of artichoke on humoral immune response

(increase of haemaglutination inhibiting antibody titer), relative

organ weight as well as on pathomorphological, haematological and

biochemical changes induced by ochratoxin A, was established.

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