A role for antibodies in the generation of memory antifungal immunity

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http://www3.interscience.wiley.com/cgi-

bin/abstract/104519938/ABSTRACT

European Journal of Immunology

Volume 33, Issue 5 , Pages 1193 - 1204

Published Online: 7 Apr 2003

© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Article

A role for antibodies in the generation of memory antifungal

immunity

Montagnoli 1, Silvia Bozza 1, Bacci 1, a

Gaziano 1, Paolo Mosci 1, Joachim Morschhäuser 2, Lucia Pitzurra 1,

Manfred Kopf 3, Jim Cutler 4, Luigina Romani 1 *

1Microbiology Section, Department of Experimental Medicine and

Biochemical Sciences, University of Perugia, Perugia, Italy

2Zentrum für Infektionsforschung, Universität Würzburg, Würzburg,

Germany

3Swiss Federal Institute of Technology Zurich, Zürich-Schlieren,

Switzerland

4Research Institute for Children, Children's Hospital, New Orleans,

USA

email: Luigina Romani (lromani@...)

*Correspondence to Luigina Romani, Department of Experimental

Medicine and Biochemical Sciences, Microbiology Section, University

of Perugia, Via del Giochetto, I-06122 Perugia, Italy Fax: +39-075-

585-7411

Keywords

B cell • Antibody • Th subset • Regulatory T cell • Fungus

Abstract

Protective immunity to Candida albicans and Aspergillus fumigatus is

mediated by antigen-specific Th1 cells. To define the role of B

cells and antibodies in the generation ofantifungal immune

resistance, B cell-deficient (MT) mice were assessed for immune

resistance to primary and secondary infections with both fungi. The

results showed that, although passive administration of antibodies

increased the fungal clearance, the innate and Th1-mediated

resistance to the primary and secondary infections were both

heightened in MT mice with candidiasis and aspergillosis. However,

although capable of efficiently restricting the fungal growth, MT

mice did not survive the re-infection with C. albicans, and this was

concurrent with the failure to generate IL-10-producing dendritic

cells and regulatory CD4+CD25+ T cells. Antifungal opsonizing

antibodies restored IL-10 production by dendritic cells from MT

mice, a finding suggesting that the availability of opsonizing

antibodies may condition the nature of the dendritic cell

interaction with fungi, possibly impacting on the development of

long-lasting antifungal immunity.

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