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Cognitive impairment associated with toxigenic fungal exposure: a replication

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15477176

1: Appl Neuropsychol. 2004;11(2):65-74.

Cognitive impairment associated with toxigenic fungal exposure: a

replication and extension of previous findings.

Gordon WA, Cantor JB, Johanning E, Charatz HJ, Ashman TA, Breeze JL,

Haddad L, Abramowitz S.

In this study, neuropsychological data and symptom reports from 31

individuals exposed to toxic mold were examined. Most participants

were found to have reduced cognitive functioning in multiple

domains, with memory and executive functions the most commonly

affected areas. Rates of dysfunction were significantly greater than

chance on more than half of the tests. Number of cognitive

impairments was found to be related to depression, although few

neuropsychological test scores were correlated with depression.

Results also indicated that symptom report of the mold-exposed

participants was not significantly different from that of matched

groups of 65 persons with mild traumatic brain injury (TBI) and 26

individuals with moderate TBI. The mold-exposed participants

reported significantly more symptoms than 47 people with no

disability. This study adds to a growing body of literature (e.g.,

Baldo, Ahmad, & Ruff, 2002; Gordon, Johanning, & Haddad, 1999)

relating exposure to mycotoxins to cognitive dysfunction.

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