Dr. Bruce Kelman, Principle in GlobalTox, Inc.

[Guest guest]

FYI, GlobaxTox makes much of it's income from doing defense litigation

support work in toxic tort cases. Is it right that Dr. Kelman and Dr. Harden

of

GlobalTox should be writing papers for the International Journal of Toxicology

then profiting form this position becoming the accepted position?

Particularly if there is evidence that the original data they use to support

relevant

dose response is FLAWED!!!!!!!!!!!!!. Someone needs to look into this group.

They write papers like the ACOEM Report. They sit on several ethics in

medicine committees, determining what is and is not morally ethical guidelines.

They receive much money for expert tesitimony supporting and supported by

their OWN writings. In the mean time, many people are gravely ill and losing

their homes, health and families while these " defense experts " are profiting

tremendously from their opinions and involvement in writing the government

decision making processes.

Sharon

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____________________________________

International Journal of Toxicology Publisher: &

Francis Health Sciences, part of the & Francis Group Issue: Volume

23,

Number 1 / January-February 2004 Pages: 3 - 10 URL: _Linking

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tribution,1,1;issue,2,12;journal,5,67;linkingpublicationresults,1:100670,1)

DOI: 10.1080/10915810490265423

Risk from Inhaled Mycotoxins in Indoor Office and Residential Environments

Bruce Kelman A1, Coreen Robbins A1, Lonie Swenson A1, Hardin A1

A1 GlobalTox, Inc., Redmond, Washington, USA

Abstract:

Mycotoxins are known to produce veterinary and human diseases when consumed

with contaminated foods. Mycotoxins have also been proposed to cause adverse

human health effects after inhalation exposure to mold in indoor residential,

school, and office environments. Epidemiologic evidence has been inadequate

to establish a causal relationship between indoor mold and nonallergic,

toxigenic health effects. In this article, the authors model a maximum possible

dose of mycotoxins that could be inhaled in 24 h of continuous exposure to a

high concentration of mold spores containing the maximum reported

concentration of aflatoxins Bm1and Bm2, satratoxins G and H, fumitremorgens B

and C,

verruculogen, and trichoverrols A and B. These calculated doses are compared to

effects data for the same mycotoxins. None of the maximum doses modeled were

sufficiently high to cause any adverse effect. The model illustrates the

inefficiency of delivery of mycotoxins via inhalation of mold spores, and

suggests that the lack of association between mold exposure and mycotoxicoses

in

indoor environments is due to a requirement for extremely high airborne spore

levels and extended periods of exposure to elicit a response. This model is

further evidence that human mycotoxicoses are implausible following

inhalation exposure to mycotoxins in mold-contaminated home, school, or office

environments.

Keywords:

Aflatoxin, Fumitremorgen, Satratoxin, Tremorgen, Tricho-verrol, Verruculogen

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