ADH...

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Lorie even abstinent we all are producing alcohol I think lots more than is thought do to an auto-brewery with the square footage of a house(mainly intestines) within each of us. Why would all these enzymes exist way before distilled spirits beer wine if alcohol toxicity was not a problem in abstinent humans? The UAE study table one shows blood alcohol at times up to 3.52mg/dl without drinking. In humans, it exists in multiple forms as a dimer and is encoded by at least seven different genes. There are five classes (I-V) of alcohol dehydrogenase, but the hepatic form that is primarily used in humans is class 1. Class 1 consists of A,B, and C subunits that are encoded by the

genes ADH1A, ADH1B, and ADH1C[7] The enzyme is contained in the lining of the stomach and in the liver. It catalyzes the oxidation of ethanol to acetaldehyde: CH3CH2OH + NAD+ ¨ CH3CHO + NADH + H+ This allows the consumption of alcoholic

beverages, but its evolutionary purpose is probably the breakdown of alcohols naturally contained in foods or produced by bacteria in the digestive tract. Others believe that its evolutionary purpose is involved in vitamin A metabolism, as alcohols are relatively 'empty' calories, providing no nutritional benefit. Alcohol dehydrogenase is also involved in the toxicity of other types of alcohol: for instance, it oxidizes methanol to produce formaldehyde and ethylene glycol to ultimately yield glycolic and oxalic acids. Humans have at least six slightly different alcohol dehydrogenases. All of them are dimers (consist of two polypeptides), with each dimer containing two zinc ions Zn2+. One of those ions is crucial for the operation of the enzyme: it is located at the catalytic site and holds the hydroxyl group of the alcohol in place. Alcohol Dehydrogenase activity

varies between men and women, and between different races. For example, women are unable to process alcohol at the same rate as men because they do not express the Alcohol Dehydrogenase as highly. The level of activity may not only be dependent on level of expression but due to allelic diversity among the population. These allelic differences have been linked to region of origin.. So I think we all auto-brew some women like you a ton and due to allelic differences cannot break down due to less active ADH therefore more upregulation to variable EtG production sometimes to extreme numbers. . That would also explain why almost everone pulling positives is female. Something that would be extremely difficult to explain in any other way I can think of.. Just random thoughts in an effort to help...hang in there... All the best,r saclorie@... wrote: Help me out here, Robin. How would a lack of alcohol dehydrogenase affect EtG? I'm guessing that a person lacking this enzyme would metabolize a much higher portion of alcohol to EtG. But it still fails to explain where the alcohol is coming from in a completely abstinent person. --------- Re: Re: false positive > > > > As I read these messages regarding trying to figure > out what causes positive etg I still believe I it was > nothing I ate or drank, or inhaled. I lost 30 lbs > trying to figure out what the cause was, I still > tested positive. I had to drop out of diversion in ca. > I am wondering if the diflucan would work. What is > funny is I used to pay for a etg test on the days i > tested with compass and the test I did would be neg > and compass would be

positive. > What also amazes me is how each dec or probation > officer handles the positives, some are dismissed some > have to go to rehab. ------------