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Auditory Neuropathy

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I picked up some information on the ongoing research at University Of

Michigan, Ann Arbor. Will share with you a bit at a time. LOTS going on

there.

A NEW GENE FOR AUDITORY NEUROPATHY IDENTIFIED

The research team of Division Chief Marci Lesperance and Professor Margit

Burmeister has identified a gene mutation that causes auditory neuropathy

- a rare form of hearing loss. A mutation in the gene DIAPH3 was found

to cause an overproduction of diaphanous protein, which leads to

significant reduction in the hearing of fruit flies.

The team collected DNA from a family in which several memebers developed

hearing loss during their teenage years. The hearing loss progressed to

profound bilateral deafness, for which several family members were

successfully treated with cochlear implants. Combining genetic

inheritance information with biological function studies enabled the team

to make this significant identification. " Since we knew of only two

genes associated with auditory neuropathy, finding this gene mutation is

significant " says Dr. Lesperance. Dr. Lesperance and her colleagues

are currently recruiting research subjects for their studies aimed at

identifying other genes involved in genetic hearing loss. For more

information, see www.umclinicalstudies.org

Don't ask ME any more about it. I'm just reporting what I've read, for

anone who is interested.

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