Who invented the TSH - what name/what company/what date

[Guest guest]

Sorry Shiela, I trawled though all sorts of sites and journals looking

under various search engines and keywords but I could not find out.

I did find some natural thyroid extracts though that I had never heard

of, just posting the links in case you are interested. However I am

sure you have seen them before.

http://www.westernresearchlaboratories.com/nw_throid.asp

Good luck, I will have another search tomorrow.

God bless

Dawnx

[Guest guest]

This might put you on the right track to find the actual inventor of

the TSH test. It mentions a previous patent US Patent no. U.S. Pat.

No. 3,555,143 in 1971 but I cannot get to that. Maybe you could track

it back if you know anyone who is a member.

http://www.freepatentsonline.com/4088746.html[\url]

good luck

Dawnx

[Guest guest]

HI Dawn

The thyroid extract products such as Armour® Thyroid; Westhroid® and Nature-Throid® meet the stringent guidelines laid down by the United States Pharmacopoeia (USP), and the Food and Drug Administration (FDA). Hoewever, like Armour, they are not licensed and the MHRA did not mention them in their letter to me saying that doctors CAN prescribe Westhroid or Nature-Throid. Many people use these other products but not so many in the UK.

Many thanks for looking for the Inventor(s) of the TSH. Somebody had to invent it????

luv - Sheila

Re: Who invented the TSH - what name/what company/what date

Sorry Shiela, I trawled though all sorts of sites and journals lookingunder various search engines and keywords but I could not find out.I did find some natural thyroid extracts though that I had never heardof, just posting the links in case you are interested. However I amsure you have seen them before.http://www.westernresearchlaboratories.com/nw_throid.aspGood luck, I will have another search tomorrow.God blessDawnx

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[Guest guest]

>

> There is a discussion going on on the NTH forum about who invented

the Thyroid Stimulating Hormone test. I have never been able to find

this out and have done a bit of searching as I need this information

to

start writing the next paper on the TSH testing. Somebody mentioned

some time ago on this Forum that they thought Dr Toft had

been

involved, but I have never heard about this. Does ANYBODY know and

can

you point me in the direction where I can find evidence for this?

There

are several companies making TSH kits, but I don't want to know about

them, just the Inventor(s).

>

> I would be really grateful for any help anybody can give me on this

particularly elusive information - or is it just me?

>

> Luv - Sheila

Hello Sheila, do you mean who invented the actual test kits or the

reference value concept?

If you mean the reference value concept a Prof. Grasbeck and Prof.

Saris are mentioned on the Thyroid Tears site (on the We Can Make A

Difference page). I noticed it quotes Prof. Grasbeck as saying

that " To

make a diagnosis on the basis of only one test such as the TSH is

decision making based on thin evidence. " It also says that he's not

happy with Dr's using incorrect terminology like " normal range "

instead

of reference range.

Hope this helps:0)

Louise.

[Guest guest]

Hi Louise

http://www.westgard.com/guest27.htm#alternative. I had a look at this website but can't see that Grasbeck/Saris invented the reference value for TSH. They are discussing the concept of reference ranges (which had already been invented) but are not the inventors. The TSH test has been used for about 4 generations I believe and they had this discussion in 2004. We need to go right back and find out where it came from and what trials were conducted - how many people did they use in their trials.

Luv - Sheila

Hello Sheila, do you mean who invented the actual test kits or the reference value concept?If you mean the reference value concept a Prof. Grasbeck and Prof. Saris are mentioned on the Thyroid Tears site (on the We Can Make A Difference page). I noticed it quotes Prof. Grasbeck as saying that "To make a diagnosis on the basis of only one test such as the TSH is decision making based on thin evidence." It also says that he's not happy with Dr's using incorrect terminology like "normal range" instead of reference range. Hope this helps:0)Louise.

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[Guest guest]

Hi Sheila,

I'm sure I read this somewhere ,but have no clear remembrance, but

for some reason I think that Toft was part of the team.

Subject: Re: Who invented the TSH - what name/what

company/what date

>

> I would be really grateful for any help anybody can give me on this

particularly elusive information - or is it just me?

>

> Luv - Sheila

[Guest guest]

Hi SheilaFound this:"The consensus of thyroidologists decided in 1973 that the TSH was the

blood test they had been looking for all through the years.""the TSH arrived in the

late 60s and was boasted about as the final answer."on the following site:http://www.thyroid-info.com/articles/david-derry.htm Not very specific I'm afraid but Derry's email is listed in the article and he says that he has a massive library of thyroid info. Maybe you could ask him?Luv

[Guest guest]

Sounds like you heard the same story , but I too cannot remember where this came from.

Luv - Sheila

Hi Sheila,I'm sure I read this somewhere ,but have no clear remembrance, butfor some reason I think that Toft was part of the team.Subject: Re: Who invented the TSH - what name/whatcompany/what date> > I would be really grateful for any help anybody can give me on this particularly elusive information - or is it just me?> > Luv - Sheila

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[Guest guest]

HI sarah

Thanks for this - at last, I now have the year more or less when the TSH was invented. I have written to Dr Derry and told him what I am doing and asked, in his vast amount of literature, whether he can point me in the right direction of finding the Inventors, the exact year, the country, the number of 'patients' involved etc. I do hope he responds and will let you know if he does. Again, many thanks for this.

luv - Sheila

Hi SheilaFound this:"The consensus of thyroidologists decided in 1973 that the TSH was the blood test they had been looking for all through the years.""the TSH arrived in the late 60s and was boasted about as the final answer."on the following site:http://www.thyroid-info.com/articles/david-derry.htm Not very specific I'm afraid but Derry's email is listed in the article and he says that he has a massive library of thyroid info. Maybe you could ask him?Luv

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[Guest guest]

Not sure if the following helps at all, but in case there is some mileage in it..... I am wondering if the marked in red publication below might provide the wanted info....

love,

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1127319

Extract:

The treatments currently used for hyperthyroidism and hypothyroidism were established by the beginning of the 1970s. Though the symptoms and signs of these disorders had been analysed and clinical scoring indices had been developed and validated in the 1960s, clinical diagnosis remained problematic.4–8 The clinical diagnostic schemes for hypothyroidism were similar,4–6 but there were considerable differences between diagnostic schemes for hyperthyroidism. For example, atrial fibrillation was considered by Wayne and Crooks to be one of the most powerful discriminating signs,6,7 but it was not included by Gurney et al.8 Age, on the other hand, was a major diagnostic factor according to Gurney et al,8 but was not mentioned by Wayne or Crooks.6,7 From knowledge of the pathophysiology of the hypothalamic-pituitary-thyroid axis available at that time, it was believed that measuring the concentration of serum thyroid stimulating hormone would simplify the diagnosis.

Hypothyroidism

The publication of a reliable and practical assay for thyroid stimulating hormone was a landmark.9 A normal range of <0.5-4.2 mU/l was established, based on measurements from 29 control subjects. One of the first applications of the assay was in patients who had undergone subtotal thyroidectomy for Graves' disease.10 In 28 "unequivocally euthyroid" patients followed for three to 21 years, the mean concentration was 8.2 mU/l (range 1.3-34.0 mU/l). In four patients followed up for four to 12 years and in whom a therapeutic trial of thyroxine had shown no benefit, the thyroid stimulating hormone concentration range was 10.5-21.5 mU/l. These patients were considered to be unequivocally euthyroid by a group who had validated clinical indices for the diagnosis of hypoparathyroidism and hyperthyroidism.5,7 They were used to show the superiority of thyroid stimulating hormone measurements in detecting hypothyroidism, and no suggestion was made that the normal range could be widened.

In 1973, the data on which the concept of subclinical hypothyrodism was based were published.11 The reference range for thyroid stimulating hormone, established from measurement in 29 subjects,10 was used to classify 22 euthyroid subjects as having subclinical hypothyroidism. In six of the 22 subjects given a therapeutic trial of thyroxine, treatment showed no benefit, and 10 had originally been recruited as normal controls.

Whickham surveyThe Whickham survey was a further landmark.12 All Whickham residents with a serum thyroid hormone concentration >6 mU/l were diagnosed as being hypothyroid, irrespective of their clinical status. This reinforced the view that the serum thyroid stimulating hormone concentration defined hypothyroidism. The 20 year follow up study of the Whickham survey has yielded invaluable data on the natural history of thyroid disorders.13 A main conclusion of the study, disseminated to most non-specialists in a review published in the BMJ, was that "thyroid stimulating hormone concentrations above 2 mU/l are associated with an increased risk of hypothyroidism."2 Half of the population (male and female) fall into this category.12 This conclusion was based on the change in the slope of the line obtained when the log of the serum thyroid stimulating hormone concentration was related to the logit probability of developing hypothyroidism over a 20 year period in women (see box).13 The probability of a 40 year old woman with a thyroid stimulating hormone of 2.1 mU/l developing hypothyroidism is low—at 1 in 50 over 20 years. In men, the probability is so low that an equivalent equation could not be derived.13

[Guest guest]

Hi and Dawn

This is - as they say, doing my poor little head in....Dawn sent me info that pointed me in the direction of the patent - which points to it being an American patent. I need the full story from somewhere. I am a bit tired right now, but hope to try again later. http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6631417

Seems the 'Inventors' could have been Hall R, Amos J, Ormston BJ. Radioimmunoassay of human serum thyro­ trophin. BMJ 1971;i:582­5.10. However, I would have thought there would have been something earlier, in the 1960's. Need a rest.

Luv - Sheila

Re: Who invented the TSH - what name/what company/what date

Not sure if the following helps at all, but in case there is some mileage in it..... I am wondering if the marked in red publication below might provide the wanted info....

love,

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1127319

Extract:

The treatments currently used for hyperthyroidism and hypothyroidism were established by the beginning of the 1970s. Though the symptoms and signs of these disorders had been analysed and clinical scoring indices had been developed and validated in the 1960s, clinical diagnosis remained problematic.4–8 The clinical diagnostic schemes for hypothyroidism were similar,4–6 but there were considerable differences between diagnostic schemes for hyperthyroidism. For example, atrial fibrillation was considered by Wayne and Crooks to be one of the most powerful discriminating signs,6,7 but it was not included by Gurney et al.8 Age, on the other hand, was a major diagnostic factor according to Gurney et al,8 but was not mentioned by Wayne or Crooks.6,7 From knowledge of the pathophysiology of the hypothalamic-pituitary-thyroid axis available at that time, it was believed that measuring the concentration of serum thyroid stimulating hormone would simplify the diagnosis.

Hypothyroidism

The publication of a reliable and practical assay for thyroid stimulating hormone was a landmark.9 A normal range of <0.5-4.2 mU/l was established, based on measurements from 29 control subjects. One of the first applications of the assay was in patients who had undergone subtotal thyroidectomy for Graves' disease.10 In 28 "unequivocally euthyroid" patients followed for three to 21 years, the mean concentration was 8.2 mU/l (range 1.3-34.0 mU/l). In four patients followed up for four to 12 years and in whom a therapeutic trial of thyroxine had shown no benefit, the thyroid stimulating hormone concentration range was 10.5-21.5 mU/l. These patients were considered to be unequivocally euthyroid by a group who had validated clinical indices for the diagnosis of hypoparathyroidism and hyperthyroidism.5,7 They were used to show the superiority of thyroid stimulating hormone measurements in detecting hypothyroidism, and no suggestion was made that the normal range could be widened.

In 1973, the data on which the concept of subclinical hypothyrodism was based were published.11 The reference range for thyroid stimulating hormone, established from measurement in 29 subjects,10 was used to classify 22 euthyroid subjects as having subclinical hypothyroidism. In six of the 22 subjects given a therapeutic trial of thyroxine, treatment showed no benefit, and 10 had originally been recruited as normal controls.

Whickham surveyThe Whickham survey was a further landmark.12 All Whickham residents with a serum thyroid hormone concentration >6 mU/l were diagnosed as being hypothyroid, irrespective of their clinical status. This reinforced the view that the serum thyroid stimulating hormone concentration defined hypothyroidism. The 20 year follow up study of the Whickham survey has yielded invaluable data on the natural history of thyroid disorders.13 A main conclusion of the study, disseminated to most non-specialists in a review published in the BMJ, was that "thyroid stimulating hormone concentrations above 2 mU/l are associated with an increased risk of hypothyroidism."2 Half of the population (male and female) fall into this category.12 This conclusion was based on the change in the slope of the line obtained when the log of the serum thyroid stimulating hormone concentration was related to the logit probability of developing hypothyroidism over a 20 year period in women (see box).13 The probability of a 40 year old woman with a thyroid stimulating hormone of 2.1 mU/l developing hypothyroidism is low—at 1 in 50 over 20 years. In men, the probability is so low that an equivalent equation could not be derived.13

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[Guest guest]

Dear Sheila

an part-corrected translation of a statement from the German PhD

thesis:

http://www.scirus.com/srsapp/sciruslink?src=ndl & url=http%3A%2F%

2Fedoc.ub.uni-muenchen.de%2Farchive%2F00005122%2F

http://edoc.ub.uni-muenchen.de/5122/

http://edoc.ub.uni-muenchen.de/5122/1/Alajbegovic_Lejla.pdf

[[...Since the study of Prange (1972) and in more than 50

investigations, in which over 1000 patients were tested it was shown

that the TSH value from TRH is decreased with approximately 25% of

the patients with acute depressive illness, whereas in the

remitting? phase there were still ca,14% of the patients show a

decreased TSH value, i.e. with less than half of the patients with

depressive illness the TRH induced TSH TSH-Stimulation normalizes

itself in the remission phase (Loosen, 1985). In later studies

however no significant difference between the test results of

depressive patients and healthy probands? was determined (Ruby et al,

1987; Baumgartner et al, 1988b; Bartalen et al, 1990).

The causes for these contradictory findings are various: Application

different TRH dosage, different estimates of the maximum TSH level,

different definitions for a pathologically failing TRH test. Also the

laboratory methods for the measurement of Thyreotropin developed

themselves further in last years: RIA methodology used in former

times was replaced by the employment by substantially improved IRMA

and/or MAIA kit. This method shows a very high Sensitivity, in

particular, in the lower ranges relevant for the measurement of basal

TSH 'ranges?'....]]

I'll see what the other references say:-

best wishes

Bob

>

> There is a discussion going on on the NTH forum about who invented

the Thyroid Stimulating Hormone test. I have never been able to find

this out and have done a bit of searching as I need this information

to start writing the next paper on the TSH testing. Somebody

mentioned some time ago on this Forum that they thought Dr

Toft had been involved, but I have never heard about this. Does

ANYBODY know and can you point me in the direction where I can find

evidence for this? There are several companies making TSH kits, but I

don't want to know about them, just the Inventor(s).

>

> I would be really grateful for any help anybody can give me on this

particularly elusive information - or is it just me?

>

> Luv - Sheila

>

[Guest guest]

Thank you Bob. Does this mean that different 'kits' give different results?

Luv - Sheila

Re: Who invented the TSH - what name/what company/what date

Dear Sheilaan part-corrected translation of a statement from the German PhD thesis:http://www.scirus.com/srsapp/sciruslink?src=ndl & url=http%3A%2F%2Fedoc.ub.uni-muenchen.de%2Farchive%2F00005122%2Fhttp://edoc.ub.uni-muenchen.de/5122/http://edoc.ub.uni-muenchen.de/5122/1/Alajbegovic_Lejla.pdf[[...Since the study of Prange (1972) and in more than 50 investigations, in which over 1000 patients were tested it was shown that the TSH value from TRH is decreased with approximately 25% of the patients with acute depressive illness, whereas in the remitting? phase there were still ca,14% of the patients show a decreased TSH value, i.e. with less than half of the patients with depressive illness the TRH induced TSH TSH-Stimulation normalizes itself in the remission phase (Loosen, 1985). In later studies however no significant difference between the test results of depressive patients and healthy probands? was determined (Ruby et al, 1987; Baumgartner et al, 1988b; Bartalen et al, 1990).The causes for these contradictory findings are various: Application different TRH dosage, different estimates of the maximum TSH level, different definitions for a pathologically failing TRH test. Also the laboratory methods for the measurement of Thyreotropin developed themselves further in last years: RIA methodology used in former times was replaced by the employment by substantially improved IRMA and/or MAIA kit. This method shows a very high Sensitivity, in particular, in the lower ranges relevant for the measurement of basal TSH 'ranges?'....]]I'll see what the other references say:-best wishesBob>> There is a discussion going on on the NTH forum about who invented the Thyroid Stimulating Hormone test. I have never been able to find this out and have done a bit of searching as I need this information to start writing the next paper on the TSH testing. Somebody mentioned some time ago on this Forum that they thought Dr Toft had been involved, but I have never heard about this. Does ANYBODY know and can you point me in the direction where I can find evidence for this? There are several companies making TSH kits, but I don't want to know about them, just the Inventor(s).> > I would be really grateful for any help anybody can give me on this particularly elusive information - or is it just me?> > Luv - Sheila>

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[Guest guest]

Dear Sheila,

It looks like that was the move towards greater sensitivity using

updated technology (and away from RIA radio-immuno assay).

best wishes

Bob

> >

> > There is a discussion going on on the NTH forum about who

invented

> the Thyroid Stimulating Hormone test. I have never been able to

find

> this out and have done a bit of searching as I need this

information

> to start writing the next paper on the TSH testing. Somebody

> mentioned some time ago on this Forum that they thought Dr

> Toft had been involved, but I have never heard about this. Does

> ANYBODY know and can you point me in the direction where I can

find

> evidence for this? There are several companies making TSH kits,

but I

> don't want to know about them, just the Inventor(s).

> >

> > I would be really grateful for any help anybody can give me on

this

> particularly elusive information - or is it just me?

> >

> > Luv - Sheila

> >

>

>

>

>

>

>

> --------------------------------------------------------------------

----------

>

>

> No virus found in this incoming message.

> Checked by AVG.

> Version: 7.5.519 / Virus Database: 269.22.11/1371 - Release Date:

10/04/2008 12:23

>

[Guest guest]

>>Many thanks for looking for the Inventor(s) of the TSH. Somebody had to invent it????<<<

Perhaps after seeing how it has been used they are so ashamed of themselves they want to remain anonymous

Lilian

[Guest guest]

Hi Lilian,

I rather think it was the value in allowing doctors to distinguish the

alcoholics (cirrhotic livers) from the rest that led to the adoption of

the 'TSH is God' stance.....and the main reason that they didn't really

want to have to validate this 'other reason' ie a 'done deal' behind

closed doors.

best wishes

Bob

>

> >>Many thanks for looking for the Inventor(s) of the TSH. Somebody

had to invent it????<<<

>

> Perhaps after seeing how it has been used they are so ashamed of

themselves they want to remain anonymous

>

> Lilian

>

[Guest guest]

Hi Sheila,

Here is the link to Ednas history site which may hold the key to the

original TSH research for this dreadful range:

//www.thyroidhistory.net/

I asked over at the about.com forum and reminded me of Ednas work.

Sorry I havent found the research, bit under the weather today but

didnt want the link to go unposted. I was also under the impression

it was on the thyroidaustralia site, but couldnt find it

jennyfreeman

>

> Thank you Bob. Does this mean that different 'kits' give different

results?

>

>

[Guest guest]

Hi Shiela,

Yes have a rest, it does do your head in.

I have written to a lady PhD in America, a Dr Rebacker, who lectures

on endocrinology, she was doing one talk on the TSH testing. She is

from Washington Medical School I think. Anyway it is worth a shot, she

may know.

I am waiting for a reply.

God bless

Dawn

[Guest guest]

Sorry its Ann Granowski I have written to, that other name is not

right lol. Still dippy Dawn x

[Guest guest]

Hi Bob

I believe the TSH test came in with T4 thyroxine (laterlly called

Levothyroxine) treatment.

L-thyroxine was in fact originally natural animal thyroxine and

blood tests were based on T3 uptake, T4 and FT index or T7.

Those receiving T4 treatment had TSH and FT4 tests.

Luv

Chris

> >

> > >>Many thanks for looking for the Inventor(s) of the TSH.

Somebody

> had to invent it????<<<

> >

> > Perhaps after seeing how it has been used they are so ashamed of

> themselves they want to remain anonymous

> >

> > Lilian

> >

>

[Guest guest]

.....Oh - and how to write this in a report that we need to be taken seriously - where's the concrete evidence? *Sigh!*

Luv - Sheila

Hi Lilian,I rather think it was the value in allowing doctors to distinguish the alcoholics (cirrhotic livers) from the rest that led to the adoption of the 'TSH is God' stance.....and the main reason that they didn't really want to have to validate this 'other reason' ie a 'done deal' behind closed doors.best wishesBob>> >>Many thanks for looking for the Inventor(s) of the TSH. Somebody had to invent it????<<<> > Perhaps after seeing how it has been used they are so ashamed of themselves they want to remain anonymous > > Lilian>

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[Guest guest]

Thanks , I will have a look at that. It's beginning to feel like trying to find the proverbial needle in the haystack.

luv - Sheila

Hi Sheila,Here is the link to Ednas history site which may hold the key to theoriginal TSH research for this dreadful range://www.thyroidhistory.net/I asked over at the about.com forum and reminded me of Ednas work.Sorry I havent found the research, bit under the weather today butdidnt want the link to go unposted. I was also under the impressionit was on the thyroidaustralia site, but couldnt find itjennyfreeman>> Thank you Bob. Does this mean that different 'kits' give differentresults?> >

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[Guest guest]

Surely there is some message here in the fact that it is so difficult to find, yet the majority of doctors rely on it. They need references, research results, for everything - so where are all the studies regarding TSH?

Perhaps we should be asking the doctor for their proof and the research they rely on that TSH is the be all and end all of thyroid testing.

Lilian

Thanks , I will have a look at that. It's beginning to feel like trying to find the proverbial needle in the haystack.

[Guest guest]

Bless you Dawn for doing this. I hope she can help give me the answers I need. I am getting all sorts of information, but nothing that I can actrually use yet. I believe that is asking on Shomons American forum too, and they have some good guys and gals, so we will see if they too can come up with something. When I first asked this question, I had no idea it would cause such a stir. I am collecting so much other 'good' information for my TSH paper, but I can't even get it off the ground until I have got the basic info - and more importantly, the evidence.

luv - Sheila

Re: Who invented the TSH - what name/what company/what date

Hi Shiela,Yes have a rest, it does do your head in.I have written to a lady PhD in America, a Dr Rebacker, who lectureson endocrinology, she was doing one talk on the TSH testing. She isfrom Washington Medical School I think. Anyway it is worth a shot, shemay know.I am waiting for a reply.God blessDawn

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