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Hi Simon, I think from your results Dr P will probablyrecommend HC. However, I do not see that you have a normal-shaped cortisol profile this time.Your cortisol should be at the highest first thing when you wake up to help you get through the usual chores of the day and generally give you the energy you need. In fact the first three samples are below the range, and the one before you go to sleep, when your corotisol should be right at the bottom of the range has suddenly decided to go into the middle of the range. This most definitely shows your body is not making enough cortisol and your NAE will not be potent enough to actually help your situation. It looks like it might help your DHEA levels also if you started adding say, 25mgs DHEA and building this up with your cortisol levels.

Dr P has a clionic in Leeds on 22nd, 23rd and 24th October - and at my cottage on Saturday 25th and 26th October if you need a follow up appointment Simon.

Luv - Sheila

I'm currently taking 4 NAE a day (obviously I stopped a week beforethese tests) supplemented by vitamin C, co-enzyme Q10 and siberianginseng, without any signs of improvement, so I suspect that next timeI see Dr Peatfield he'll probably recommend HC. Before going down thatroad, I was just wondering whether anyone could think of something Imight have overlooked?Best wishes,SimonInside OutsideCortisol Levels Range RangeSample 1 Post Awakening 11.8 L (ref. 12-22)Sample 2 (+ 4 - 5 Hours) 3.5 L (ref. 5-9)Sample 3 (+ 4 - 5 Hours) 2.7 L (ref. 3-7)Sample 4 (Prior to Sleep) 2.3 (ref. 1-3)DHEA Levels Sample 2 (am) 0.43 (ref. 0.4-1.7)Sample 3 (pm) 0.34 L (ref. 0.4-1.7)>>

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These results are very similar to mine in a way, the first 3 of my samples were below the range and the only one to go over range was the midnight one, I think when results are like this NAE and the like just wont be enough to get you to make more cortisol, which is what you and I need. I tried NAE for 6 weeks and have now gone on the HC, I think when a hormone is lacking the only way is to replace it is with hormone replacement, in this case HC. Still early days for me and I have not restarted my Thyroxine yet and I think when I do at the end of this week things might 'get moving' Thats my plan anyway, but I dont want to rush things, although I would love to, I know I cant, but I will be pleased when I can restart the T4, my body must be needing it again by now

From: sheilaturner <sheilaturner@...>Subject: Re: My adrenal stress profile reportthyroid treatment Date: Monday, 25 August, 2008, 10:10 AM

Hi Simon,

Dr P has a clionic in Leeds on 22nd, 23rd and 24th October - and at my cottage on Saturday 25th and 26th October if you need a follow up appointment Simon.

Luv - Sheila

I'm currently taking 4 NAE a day (obviously I stopped a week beforethese tests) supplemented by vitamin C, co-enzyme Q10 and siberianginseng, without any signs of improvement, so I suspect that next timeI see Dr Peatfield he'll probably recommend HC. Before going down thatroad, I was just wondering whether anyone could think of something Imight have overlooked?Best wishes,SimonInside OutsideCortisol Levels Range RangeSample 1 Post Awakening 11.8 L (ref. 12-22)Sample 2 (+ 4 - 5 Hours) 3.5 L (ref. 5-9)Sample 3 (+ 4 - 5 Hours) 2.7 L (ref. 3-7)Sample 4 (Prior to Sleep) 2.3 (ref. 1-3)DHEA Levels Sample 2 (am) 0.43 (ref. 0.4-1.7)Sample 3 (pm) 0.34 L (ref. 0.4-1.7)>>

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Hi ,

The very low daytime cortisol condemns you to the anabolic phase all

day long, ie no catabolic (knocking down) phase in the mornings.

If no catabolic phase, there is no 'kit' lying around with which to

get on with the anabolic (building up) phase in the afternoons.

The need for lots of supplements during this low cortisol period is

paramount, unless you can muster up some cortisol or similar.

A secondary reason that using a long-acting steroid will mess up the

works.....you don't go through a satisfactory anabolic phase during

the 'normal' day........

no cortisol in the daytime (AM) needs supplementing and doing too

much with too little.

too much cortisol in the daytime (Cushing's) = perpetual catabolic

phase ~ ie, no let up....working your socks off to de-construct the

working parts, but with too much 'kit' you go under......by peeing it

all out.

is this obvious why you need the cortisol and not the long-acting

steroids?

brain, temporarily? in gear, at the second attempt

best wishes

Bob

>

> These results are very similar to mine in a way, the first 3 of my

samples were below the range and the only one to go over range was

the midnight one,

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Hi Bob

So cortisol is what I need and am taking to raise these levels? The highest amount of cortisol to be taken in the morning, followed by smaller amounts maybe throughout the day? I dont intend taking any at bed time as I dont think its needed. It is obvious I need the cortisol and not the long acting steriod

From: bob.m9uk <Bob.m9uk@...>Subject: Re: My adrenal stress profile reportthyroid treatment Date: Monday, 25 August, 2008, 1:19 PM

Hi ,The very low daytime cortisol condemns you to the anabolic phase all day long, ie no catabolic (knocking down) phase in the mornings.If no catabolic phase, there is no 'kit' lying around with which to get on with the anabolic (building up) phase in the afternoon.The need for lots of supplements during this low cortisol period is paramount, unless you can muster up some cortisol or similar.brain, temporarily in gearbest wishesBob>> These results are very similar to mine in a way, the first 3 of my samples were below the range and the only one to go over range was the midnight one, Send instant messages to your online friends http://uk.messenger.

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Depends what adrenal support you are taking I think, if its NAE then only myabe a couple of days but if its something like HC then yes probably a week is right

From: jane winwood <janewinwood@...>Subject: Re: My adrenal stress profile reportthyroid treatment Date: Monday, 25 August, 2008, 3:37 PM

afternoon everyone; do you really need to stop adrenal support for a whole week prior to doing the saliva profile ? regards janeSend instant messages to your online friends http://uk.messenger . Send instant messages to your online friends http://uk.messenger.

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Hi Jane,

I emailed the lab & they said - well it would be more sensible to just copy their replies:

Long term steriod use can influence the above test, so would therefore need to be stopped to gauge your bodies natural response to stress. However, steriod medication may take up to 2 months to be completely out of your system & we would not advice stopping medication without speaking to your GP or nutritional practitioner first.Any adrenal glandular supplementation should be stopped for atleast 1 week before doing the test to gauge the bodies natural response to stress. However the stopping of any supplements should be discussed with your practitioner if you are working with one.

Val

afternoon everyone; do you really need to stop adrenal support for a whole week prior to doing the saliva profile ? regards jane

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If taking NAE - stop for a week - if taking HC you must stop for 6 weeks.

Luv - Sheila

afternoon everyone; do you really need to stop adrenal support for a whole week prior to doing the saliva profile ? regards janeSend instant messages to your online friends http://uk.messenger. No virus found in this incoming message.

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hi val, thanks for that ! silly me ~ i got it confused with

staying off thyroid meds prior to blood tests, and i have been

carefully filling my vials today. unfortunately i only stopped the

nae yesterday. i'll have to ask them for another kit :( jane

>

> Hi Jane,

>

> I emailed the lab & they said - well it would be more sensible to

just copy their replies:

>

>

> Long term steriod use can influence the above test, so would

therefore need to be stopped to gauge your bodies natural response to

stress. However, steriod medication may take up to 2 months to be

completely out of your system & we would not advice stopping

medication without speaking to your GP or nutritional practitioner

first.

>

>

> Any adrenal glandular supplementation should be stopped for atleast

1 week before doing the test to gauge the bodies natural response to

stress. However the stopping of any supplements should be discussed

with your practitioner if you are working with one.

>

> Val

>

>

> afternoon everyone; do you really need to stop adrenal support

for a whole week prior to doing the saliva profile ? regards jane

>

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Hi ,

If you stick to this script for a few weeks until you get the hang of

it, you'll do OK; your skill will then increase to the point where you

can speak from your own experience ~ free flying.....scary to start

with.

best wishes

Bob

> Hi Bob

> So cortisol is what I need and am taking to raise these levels? The

highest amount of cortisol to be taken in the morning, followed by

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Sheila wrote:

>However, I do not see that you have a normal-shaped cortisol profile

this time.

You must have forgotten what my last test looked like! Much lower than

this during the day, then actually rising to 34.6 nmol/l at midnight!

This time at least the curve is downward the whole time, it's just

shallower than it should be. I do wonder whether the first test had

much credibility, however, since as I said, it wasn't a normal day.

Thanks Sheila, and Bob for your advice. I'll be very interested

to hear how you're getting on, , as it looks like I might need

similar treatment.

Take care,

Simon

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Hi Simon

I will post my experiences as and when they happen, I do feel more positive and will probably be able to tell more when I re start my thyroxine, I hope!!>However, I do not see that you have a normal-shaped cortisol profileTake care,SimonSend instant messages to your online friends http://uk.messenger.

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Hi Bob What supplements are you referring to?

The need for lots of supplements during this low cortisol period is paramount, unless you can muster up some cortisol or similar,

Hi ,The very low daytime cortisol condemns you to the anabolic phase allThe need for lots of supplements during this low cortisol period is paramount, unless you can muster up some cortisol or similar.brain, temporarily in gear

These results are very similar to mine in a way, the first 3 of my samples were below the range and the only one to go over range was the midnight one, MODERATED TO REMOVE SUPERFLUOUS HEADERS ETC

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Hi ,

Those in the NAE but without the glandulars match what is needed. If

taking NAE, you are probably getting what you need, but may need to

stay on that vitamin content (without the glandulars), for a while at

least, if you convert over to hydrocortisone (as you have done)......

once the catabolic /anabolic cycle has been re-established, the demand

for those supplements may reduce, but not altogether disappear.

horses for courses etc

best wishes

Bob

>

> Hi Bob What supplements are you referring to?

> The need for lots of supplements during this low cortisol period is

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Had a cortisol test:- here's what the report said.

a) Random serum cortisols are rarely diagnostically useful.B) An overnight dexamethasone suppression test is recommended to assess the possibility of Cushings. The short Synacthen test is advised to investigate possible hypoadrenalism.

Prednisolone causes significant positive interference with cortisol analysis by this method(serum cortisol).

Anon

>> If taking NAE - stop for a week - if taking HC you must stop for 6 weeks.> > Luv - Sheila> > > > afternoon everyone; do you really need to stop adrenal support for a whole week prior to doing the saliva profile ? regards jane > > Send instant messages to your online friends http://uk.messenger. > > > No virus found in this incoming message.> Checked by AVG - http://www.avg.com > Version: 8.0.138 / Virus Database: 270.6.7/1632 - Release Date: 25/08/2008 07:05>

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Hi Bob

I did the iodine test last night, drew a graph on my inner arm below the elbow with iodine tincture and by the 3am it had completley dissappered, I painted it on at around 10.15pm.

Dr P told me to do it a few weeks ago and I did but I thought it had to completley dissappear within a few mins which of course it didnt, I have been taking 300mg of kelp for a few weeks now as the first time I did the test I wasnt sure if I needed it or not, so maybe after last nights test I should carry on with the kelp?

Are you going to do the 24hr salivary test for cortisol?

From: bob.m9uk <Bob.m9uk@...>Subject: Re: My adrenal stress profile reportthyroid treatment Date: Thursday, 28 August, 2008, 8:51 AM

Had a cortisol test:- here's what the report said.Anon

>> If taking NAE - stop for a week - if taking HC you must stop for 6 weeks.> > Luv - Sheila> > > > afternoon everyone; do you really need to stop adrenal support for a whole week prior to doing the saliva profile ? regards jane > > Send instant messages to your online friends http://uk.messenger . > > > No virus found in this incoming message.> Checked by AVG - http://www.avg. com > Version: 8.0.138 / Virus Database: 270.6.7/1632 - Release Date: 25/08/2008 07:05>Send instant messages to your online friends http://uk.messenger.

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I luv how little Anon keeps popping out *grin*. Actually, I am guessing you had this test done at the hospital under the good old NHS. This is a pretty useless test unless you do have Cushing's or 's disease.To find out whether you do have low adrenal reserve you really need the 24 hour salivary adrenal profile done at four specific times during the day - or at least one when you wake and every four hours for the next two and another one when you go to bed. Sadly, it costs around £70 but you can get this done through NPTechServices or Genova diagnostics.

Luv - Sheila

Had a cortisol test:- here's what the report said.

a) Random serum cortisols are rarely diagnostically useful.B) An overnight dexamethasone suppression test is recommended to assess the possibility of Cushings. The short Synacthen test is advised to investigate possible hypoadrenalism.

Prednisolone causes significant positive interference with cortisol analysis by this method(serum cortisol).

Anon

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Thanks Sheila. I had read that anyway, I know I am 'going on a bit and moaning'

From: sheilaturner <sheilaturner@...>Subject: Re: Re: My adrenal stress profile reportthyroid treatment Date: Thursday, 28 August, 2008, 3:31 PM

 - the following may help you:

CORTISOL DEFICIENCY

From the pages of “The Hormone Handbook†by Dr. Thierry Hertoghe.

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Hi, . Here's a message I sent to another group about iodine skin

loading tests:

The skin absorption test depends upon two assumptions: One is that

iodine in excess of what the body needs will not be absorbed through the

skin. To my knowledge there is no evidence whatsoever to support that

assumption. The second assumption is that if the iodine placed on your

skin over night gets lighter in color it has been absorbed. This is not

only NOT established; it is very unlikely that it can. For one thing

iodine evaporates into the air; and I believe that the humidity of that

air is a big factor.

I personally did an experiment with the latter: I repeatedly dipped a

white cotton Q-tip into an iodine solution so that it was totally

saturated several times over. I then placed the very dark brown Q-tip

in a spot that I could observe daily. I did not keep track of the time

at all [it may have been months] but eventually the Q-tip turned back

into a spotless snow white color. You literally could not tell it had

ever been dipped into iodine at all. Maybe this " proves " that the Q-tip

needs more iodine? [ggg] Not really; but then the [in]famous iodine

skin absorption test for humans does not have sufficient accuracy to

demonstrate a need for iodine either.

The excerpt that I sent to you earlier on this subject in which iodine

loading tests were found to be not beneficial was by the same author who

publicized that procedure in the first place. These tests have been

very widely condemned by those claiming they are bogus, and now the

earliest proponent apparently agrees; although avoiding that language.

End of quote. I can probably find the material from which I got the

admission from an " iodine doc " that the iodine skin loading is [in his

words] " Not sufficiently accurate to be useful " or some such. IOW, it's

bogus; but you can't expect someone who has promoted it for a decade or

three to come right out and admit it's totally ineffective.

Regards,

>

> Posted by: " sarah s " xxsarahxx_40@...

>

<mailto:xxsarahxx_40@...?Subject=%20Re%3A%20My%20adrenal%20stress%20prof\

ile%20report>

> xxsarahxx_40 <xxsarahxx_40>

>

>

> Thu Aug 28, 2008 1:52 am (PDT)

>

> Hi Bob

> I did the iodine test last night, drew a graph on my inner arm below

> the elbow with iodine tincture and by the 3am it had completley

> dissappered, I painted it on at around 10.15pm.

> Dr P told me to do it a few weeks ago and I did but I thought it had

> to completley dissappear within a few mins which of course it didnt, I

> have been taking 300mg of kelp for a few weeks now as the first time I

> did the test I wasnt sure if I needed it or not, so maybe after last

> nights test I should carry on with the kelp?

>

> Are you going to do the 24hr salivary test for cortisol?

>

>

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Hi

Please can you remember to delete messages already read and just leave a small portion of what you are responding to. It can be so frustrating for those reading from the website or who have opted to receive a Daily Digest and it also makes more work for the moderators because we have to remove those messages before they go through to the group, but for some reason, yours have to be done almost line by line. I am not sure how you have got your account set up, but your messages come through different to other members and I cannot just highlight the bits to be removed and delete.

Can you check out your account please because something isn't quite right. You know me and computers, pretty useless, but if you are having problems, just shout and somebody with the necessary expertise will come and help you.

Luv - Sheila

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Do we know of any iodine test that IS accurate?

Luv - Sheila

End of quote. I can probably find the material from which I got the admission from an "iodine doc" that the iodine skin loading is [in his words] "Not sufficiently accurate to be useful" or some such. IOW, it's bogus; but you can't expect someone who has promoted it for a decade or three to come right out and admit it's totally ineffective.Regards,>> Posted by: "sarah s" xxsarahxx_40 (DOT) co.uk> <mailto:xxsarahxx_40 (DOT) co.uk?Subject=%20Re%3A%20My%20adrenal%20stress%20profile%20report>> xxsarahxx_40 <xxsarahxx_40>>>> Thu Aug 28, 2008 1:52 am (PDT)>> Hi Bob> I did the iodine test last night, drew a graph on my inner arm below > the elbow with iodine tincture and by the 3am it had completley > dissappered, I painted it on at around 10.15pm.> Dr P told me to do it a few weeks ago and I did but I thought it had > to completley dissappear within a few mins which of course it didnt, I > have been taking 300mg of kelp for a few weeks now as the first time I > did the test I wasnt sure if I needed it or not, so maybe after last > nights test I should carry on with the kelp?> > Are you going to do the 24hr salivary test for cortisol?>> No virus found in this incoming message.

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Sheila I have been deleting every mesaage when I have replied, I had this problem last week when Gill asked me to do the same thing but I had been doing it!

I cant understand what is going wrong then because I am def deleting messages!

From: sheilaturner <sheilaturner@...>Subject: Re: Re: My adrenal stress profile reportthyroid treatment Date: Friday, 29 August, 2008, 7:29 AM

SARAH - ITS THE BIT ABOVE THAT NEEDS DELETING - THE HEADER FROM SHEILA'S EMAIL THAT IS JUST TAKING UP SPACE. OTHERWISE THIS WOULD BE FINE AND WE DO KNOW YOU'RE TRYING - MAYBE YOU NEED TO CHECK WITH YOUR PROVIDER AS YOUR MESSAGES ARE COMING IN A STRANGE FORMAT THAT MAKES IT HARD TO DELETE. Gill X

 Hi

Please can you remember to delete messages

Luv - Sheila

No virus found in this incoming message.

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Just checked my sent messages and they show I have been deleting previous messages, not sure what else I can do Sheila?

From: sheilaturner <sheilaturner@...>Subject: Re: Re: My adrenal stress profile reportthyroid treatment Date: Friday, 29 August, 2008, 7:29 AM

 Hi

Luv - Sheila

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HI

I think there is a problem with your settings. I will try to fathom out what is wrong when I have had a good nights sleep. I am very tired today as I am the only Moderator that is around right now. When your messages come through to the forum to be approved, they are very different to the messages other people send, so we probably need to check out why this is.

We all forget to delete the previous messages at times, drat - I know I do, and my other moderators keep telling me off for this, but I tell myself I have an excuse, 'cos I'm busy trying to answer every message - *grin*, but there is definitely a problem with your posts. Off to bed right now, so will try to solve this annoying problem tomorrow - if I wake up.

Luv - Sheila

Sheila I have been deleting every mesaage when I have replied, I had this problem last week when Gill asked me to do the same thing but I had been doing it!

I cant understand what is going wrong then because I am def deleting messages!

From: sheilaturner <sheilaturnertpa-uk (DOT) org.uk>Subject: Re: Re: My adrenal stress profile reportthyroid treatment Date: Friday, 29 August, 2008, 7:29 AM

SARAH - ITS THE BIT ABOVE THAT NEEDS DELETING - THE HEADER FROM SHEILA'S EMAIL THAT IS JUST TAKING UP SPACE. OTHERWISE THIS WOULD BE FINE AND WE DO KNOW YOU'RE TRYING - MAYBE YOU NEED TO CHECK WITH YOUR PROVIDER AS YOUR MESSAGES ARE COMING IN A STRANGE FORMAT THAT MAKES IT HARD TO DELETE. Gill X  Hi

Please can you remember to delete messages

Luv - Sheila

No virus found in this incoming message.

Checked by AVG - http://www.avg. com Version: 8.0.138 / Virus Database: 270.6.10/1638 - Release Date: 27/08/2008 19:06

Send instant messages to your online friends http://uk.messenger.

No virus found in this incoming message.Checked by AVG - http://www.avg.com Version: 8.0.169 / Virus Database: 270.6.13/1641 - Release Date: 29/08/2008 07:07

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