Re: please help - i am in pain and am not quite sure what to do next

[Guest guest]

Thanks very much Sheila!

P

> You can read all about Armour in my response to the BTA Statement

http://www.tpa-uk.org.uk/resp_bta_armour.pdf , but the part you are

interested tells you that Armour does have a higher amount of T3

compared to T4 than the relative amounts of T3 to T4 secreted by the

human thyroid gland. However it is well documented that Armour is

often more effective and is better tolerated than synthetic

preparations of T4, T3 and T4/T3 combination. This is because the T3

in natural thyroid extract is absorbed more slowly than synthetic

(purified, unbound) T3.......The normal thyroid gland contains

approximately 200 mcg of T4 per gram of gland, and 15 mcgs of T3 per

gram. The ratio of these two hormones in the circulation does not

represent the ratio of the thyroid gland, since about 80% of

peripheral T3 comes from monodeiodination of T4. Peripheral

monodeiodination of T4 also results in the formation of reverse T3,

which is iatrogenically inactive.

[Guest guest]

I remember you mentioning that Sheila. If I get no joy from my

current situation, I will talk to the docs about the possibility of

using NTE.

P

>

> I had severe pain with L-thyroxine alone therapy. It was only when I

changed to Armour that the pain left me. I definitely would be

wheelchair bound had I not found Armour.

[Guest guest]

Hi P

No of course I don't mind.I am very happy to help if I can. Well here

goes. I have had foot pain for many years and the whole reason I was

diagnosed with Hypothyroidism was because of body pain. I have

complained to my GP for years about it and recently got a new doctor.

He sent me to see many specialists before deciding to send me to a

rhumatoligist. Each specialist was completely fogged by my symptoms

and passed me on to the next one. Then when I eventually got to see

the rhumatologist she seemed to think my symptoms were cut and dried.

I am in pain all the time. In the morning getting out of bed is

difficult as I am very stiff.After a while that wears off to some

extent and I am able to get on with the tasks of the day. The fact

that anti inflammatory medication worked for me showed I had some type

of Inflammatory condition. I was also aware that there was psoriasis

in the family and I suppose that simply was the last piece of the

puzzle for the doctor.I do hope that this has helped. Anything else

you wish to know please just ask.

regards Frances

> >

> >There are as far as I know no

> > difinative test for psoriatic arthritis but then I am no expert. As

> > this is all very new to me I am learning all the time about it.

> >

>

[Guest guest]

http://www.fasebj.org/cgi/content/abstract/04-2664fjev1

The antipsoriatic drug anthralin accumulates in keratinocyte

mitochondria, dissipates mitochondrial membrane potential, and

induces apoptosis through a pathway dependent on respiratory

competent mitochondria

> >

> >There are as far as I know no

> > difinative test for psoriatic arthritis but then I am no expert.

As

> > this is all very new to me I am learning all the time about it.

> >

>

[Guest guest]

Hello Pat,

I came across this in a newsletter that was sent to me. It seems to

confirm what you thought about boswellia.

http://www.vitapal.com/crm/browser/dhp081308.htmutm_source=email & utm_med

ium=email & utm_term=link_browser & utm_campaign=email_daily_health_tip

regards,

M.

>

> My doctor suggested a supplement that contains ginger, celery, and

> boswellia (frankincense). Apparently it is a really good

> anti-inflammatory and analgesic. I really hope it alleviates some of

> my symptoms and pain. Here is some general information about

> boswellia, for interest sake. It has apparently been used in

> Ayurvedic medicine for years.

> http://www.ayurvedic-medicines.com/herbs/shallaki.html

>

> I no longer know what will and won't help.

>

> P

[Guest guest]

Hi ,

I couldn't get the link to work (I copied the whole thing and pasted

it into my browser but it still didn't work). I'd love to read it.

P

>

> Hello Pat,

>

> I came across this in a newsletter that was sent to me. It seems to

> confirm what you thought about boswellia.

http://www.vitapal.com/crm/browser/dhp081308.htmutm_source=email & utm_med

> ium=email & utm_term=link_browser & utm_campaign=email_daily_health_tip

[Guest guest]

Hi ,

Thanks for copying the article and pasting it here.

Much appreciated!!!!!

P

[Guest guest]

Hi P,

http://www.jbc.org/cgi/content/abstract/C800156200v1?papetoc

[[...The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women....]]

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

I think this is progress ~

Bob

>> Hi Frances,> Hope that you don't mind me asking another question. How did they diagnose you? You mentioned there is no definitive test.

[Guest guest]

Hi Bob,

I didn't see this message until today.

Thanks for the info. I've copied the info elsewhere and will have a

good look at it. I'll raise it with the doc.

P

>

> Hi P,

> Your doc won't be familiar with this paper, published yesterday,

dealing

> with the intricacies of mitchondrial membrane potentials

>

> but the inference is that a wider understanding of this subject is

being

> confirmed by many researchers carrying out both theoretical and

> investigative studies.......

[Guest guest]

Hi Bob,

I don't get what it means in relation to my situation. From what I

can gather my urate levels were ok.

P

>

>

> Hi P,

>

> http://www.jbc.org/cgi/content/abstract/C800156200v1?papetoc

> <http://www.jbc.org/cgi/content/abstract/C800156200v1?papetoc>

>

> [[...The proportion of the variance of serum uric acid

concentrations

> explained by genotypes was about 1.2% in men and 6% in women, and

the

> percentage accounted for by expression levels was 3.5% in men and

15% in

> women....]]

>

> SLC2A9 influences uric acid concentrations with pronounced sex-

specific

> effects

>

> I think this is progress ~

>

> Bob

[Guest guest]

http://www.nature.com/cdd/journal/v14/n5/full/4402099a.html

Regulation of autophagy by the inositol trisphosphate receptor

Edited by M Piacentini

[[.....The first step of macroautophagy consists in the gradual envelopment of cytoplasmic material (cytosol and/or organelles) in the phagophore, a cistern that finally sequesters cytoplasmic material in autophagosomes (also called autophagic vacuoles (AVs)) lined by two membranes. Autophagosomes then undergo a progressive maturation by fusion with endosomes and/or lysosomes. This latter step creates autolysosomes in which the inner membrane as well as the luminal content of the AVs is degraded by lysosomal enzymes. The process of autophagy is controlled by a series of evolutionary conserved genes, the atg genes, whose products are essential for specific steps of the autophagic process.1, 2

One of the strongest triggers of autophagy is nutrient stress.3, 4 In response to starvation, cells degrade nonessential components thereby generating nutrients for meeting the cell's energetic demand as well as for vital biosynthetic reactions........

See what Lithium does in this process....

I wonder how this relates to my experience of fixing the hypnic headache using lithium?

......then again, it also works in 'fixing' Bipolar Disorder??

is something of this nature causing your RT3 to go high....did you make any progress with your doc? any ideas?....

were there any clues about it being Mitochondrial or Endoplasmic Reticulum based autophagy, possibly?

best wishes

Bob

> Hi Bob,> I don't get what it means in relation to my situation.