MARY/Hashimoto's & Lyme

[Guest guest]

- I came across this on another thyroid board & saw that you

had posted about difficulty with iodine & having both hashi's &

Lyme. I wondered if there could be any correlation?

This research isn't about iodine, per se, but I thought you might

find it of interest:

Homologies between proteins of Borrelia burgdorferi and thyroid

autoantigens.

http://tinyurl.com/y3nqtm

Subclinical exposure to microbic antigens that share amino acid

sequence homology with self antigens might trigger autoimmune

diseases in genetically predisposed individuals via molecular

mimicry. Genetic predisposition to Graves' disease (GD) or

Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or DR5,

respectively. Yersinia enterocolitica (YE) outer proteins (YOPs) are

candidate triggers based on the high prevalence of serum antibodies

(Ab) against YOPs in autoimmune thyroid diseases (AITD) and

reactivity of these Ab with hTSH-R, suggesting homology between YOPs

and hTSH-R. We have reported previously that the spirochete Borrelia

burgdorferi (Bb) could be another trigger. We have explored further

the homology of hTSH-R with YE and Bb. Using the Basic Local

Alignment Search Tool (BLAST), we found four matches with YE and

five matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749

of hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

(identity 23-31%, similarity 40-48%). Residues 112-205, 127-150, 141-

260, 299-383 and 620-697 of hTSH-R matched outer surface protein A,

flagellar motor rotation protein A, two hypothetical proteins (BBG02

and BBJ08) and DNA recombinase/ATP dependent helicase of Borrelia

(identity 27-50%, similarity 40-75%). Interestingly, the above hTSH-

R regions coincide with (or include) known human T-cell epitopes: aa

52-71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen

the hypothesis of Bb and YE as environmental triggers of AITD in

genetically predisposed persons through molecular mimicry mechanisms.

[Guest guest]

Thanks so much for posting this....and yes I found it quite interesing.

I have always thought there might be correlation between lyme and

hashi', especially since I know I have had lyme a lot longer than

hashi's. I have had lyme symptoms for at least 25-30 years, but was

never diagnosed until recently. Thanks again for this. I am printing it

out so I can digest it more. V

>

> - I came across this on another thyroid board & saw that you

> had posted about difficulty with iodine & having both hashi's &

> Lyme. I wondered if there could be any correlation?

>

> This research isn't about iodine, per se, but I thought you might

> find it of interest:

>

> Homologies between proteins of Borrelia burgdorferi and thyroid

> autoantigens.

> http://tinyurl.com/y3nqtm