Re: Statins ~ selenoproteins deficit /disruption

[Guest guest]

Didn't I just say that 2008 will be the Year of the Patient. I can't believe this has been found out - has there been a cover up job??? Can the sufferers claim compensation? Will there be law suits up and down the country? What are they going to do with all the statins now they have found this out? What will they next recommend patients to take to bring down their bad cholesterol. Do you think they might one day go back to diagnosing hypothyroidism because of high cholesterol like the good old days and realise that by treating hypothyroidism, cholesterol naturally goes down anyway.

Amazing news Bob. I would like to be a fly on the wall on certain people's offices. What will Colin Dayan say now?

Do you have a full copy of the paper because I'm not a member and can't afford it. If not, has anybody else got access?

Thanks for this...now - watch this space. BUM BUM

Luv - Sheila

Statins ~ selenoproteins deficit /disruption

J. Biol. Chem., Vol. 283, Issue 4, 99902, January 25, 2008 Selenoprotein Depletion in Mice

Selenoproteins play essential roles in both development and adulthood, mainly through their functions in balancing cellular redox levels. Because selenoproteins require a trace micronutrient and specialized translational machinery, however, they seem ill-suited to handle rapid or drastic changes in redox state.

In this Paper of the Week, Takafumi Suzuki and colleagues examine how cells cope with selenoprotein depletion that may be brought on by dietary deficiencies in selenium or translational inhibition by statin drugs. They developed a conditional knock-out mouse for the selenocysteine tRNA gene (Trsp) and observed that Trsp deletion in macrophages or liver resulted in the induction of several cytoprotective agents to counter the elevated oxidative stress. The up-regulated antioxidants, which include glutathione S-transferase P1 and NAD(P)H quinone oxidoreductase 1, are known targets of the transcription factor Nrf2, and mice with a double knock-out of Trsp and Nrf2 displayed a severely compromised cytoprotective response, increased cellular apopt osis, and a reduced survival rate. These results reveal that the Nrf2 gene battery acts as a rapid response agent to assist or replace selenoprotein activity when necessary

http://www.jbc.org/cgi/content/full/283/4/e99902

legs feeling weak, barely able to walk, unbalanced, fallen over?

ask your doctor why you are using statins, especially if you have high cholesterol due to hypothyroidism...?

this editorial refers to a 'Paper of the Week' in the Journal of Biological Chemistry ~ published online this week...

http://www.jbc.org/cgi/content/full/jbc;283/4/2021

some big questions need answers....

Bob (guest)

No virus found in this incoming message.Checked by AVG Free Edition. Version: 7.5.516 / Virus Database: 269.19.7/1232 - Release Date: 18/01/2008 19:32

[Guest guest]

and it's (JBC) an open access site, essentially ~ don't have to join

it, the author's manuscripts go up the day they are approved...look

for the version v1 ~ click that, it shows the author's manuscript

that was approved .....download the pdf at the bottom of the list

(RHS) via 'save as' (from this page)

http://www.jbc.org/cgi/reprint/M708352200v1

figure 8

shows what goes on for the initiated ~ very roughly, 'translated'

into English.....the selenium can't be loaded because the transfer

RNA can't latch onto the 'stop codon' (UGA) that indicates

(unusually) that a selenoamino acid is to be inserted at that point,

instead of an 'ordinary' amino acid.....ie not 'translated' in the

biochemical sense....

Bob

>

> Didn't I just say that 2008 will be the Year of the Patient. I

can't believe this has been found out - has there been a cover up

job??? Can the sufferers claim compensation? Will there be law suits

up and down the country? What are they going to do with all the

statins now they have found this out? What will they next recommend

patients to take to bring down their bad cholesterol. Do you think

they might one day go back to diagnosing hypothyroidism because of

high cholesterol like the good old days and realise that by treating

hypothyroidism, cholesterol naturally goes down anyway.

>

> Amazing news Bob. I would like to be a fly on the wall on certain

people's offices. What will Colin Dayan say now?

>

> Do you have a full copy of the paper because I'm not a member and

can't afford it. If not, has anybody else got access?

>

> Thanks for this...now - watch this space. BUM BUM

>

> Luv - Sheila

>

> Statins ~ selenoproteins

deficit /disruption

>

>

> J. Biol. Chem., Vol. 283, Issue 4, 99902, January 25, 2008

>

> Selenoprotein Depletion in Mice

>

> Selenoproteins play essential roles in both development and

adulthood, mainly through their functions in balancing cellular redox

levels. Because selenoproteins require a trace micronutrient and

specialized translational machinery, however, they seem ill-suited to

handle rapid or drastic changes in redox state.

>

> In this Paper of the Week, Takafumi Suzuki and colleagues examine

how cells cope with selenoprotein depletion that may be brought on by

dietary deficiencies in selenium or translational inhibition by

statin drugs. They developed a conditional knock-out mouse for the

selenocysteine tRNA gene (Trsp) and observed that Trsp deletion in

macrophages or liver resulted in the induction of several

cytoprotective agents to counter the elevated oxidative stress. The

up-regulated antioxidants, which include glutathione S-transferase P1

and NAD(P)H quinone oxidoreductase 1, are known targets of the

transcription factor Nrf2, and mice with a double knock-out of Trsp

and Nrf2 displayed a severely compromised cytoprotective response,

increased cellular apopt osis, and a reduced survival rate. These

results reveal that the Nrf2 gene battery acts as a rapid response

agent to assist or replace selenoprotein activity when necessary

>

> http://www.jbc.org/cgi/content/full/283/4/e99902

>

> legs feeling weak, barely able to walk, unbalanced, fallen over?

>

> ask your doctor why you are using statins, especially if you have

high cholesterol due to hypothyroidism...?

>

> this editorial refers to a 'Paper of the Week' in the Journal of

Biological Chemistry ~ published online this week...

>

> http://www.jbc.org/cgi/content/full/jbc;283/4/2021

>

> some big questions need answers....

>

>

>

> Bob (guest)

>

>

>

>

>

> --------------------------------------------------------------------

----------

>

>

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.5.516 / Virus Database: 269.19.7/1232 - Release Date:

18/01/2008 19:32

>

[Guest guest]

Hi,

And here in the UK soils are low in

Selenium due to glaciation. We used to get Canadian bread Wheat where the levels

are higher- some imports are good!

Selenoprotein Depletion in Mice

dietary deficiencies in selenium

Bob (guest)