TSH and Kidney function ~ related

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Relationship between thyroid status and renal function in a general

population of unselected outpatients

Giuseppe Lippi(a), a Montagnana(a), Giovanni Targher(, Gian

Luca Salvagno(a) and Gian Cesare Guidi(a)

(a)Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-

Biomediche, Università di Verona, Italy, (b)Sezione di Endocrinologia

e Malattie del Metabolismo, Dipartimento di Scienze Biomediche e

Chirurgiche, Università di Verona, Italy

Received 18 September 2007;

revised 20 November 2007;

accepted 17 January 2008.

Available online 5 February 2008.

Abstract

Objective

To investigate the relationship between thyroid and kidney function.

Design and methods

13,383 results of serum creatinine and thyroid stimulating hormone

(TSH) were retrieved from the database of our Laboratory.

Results

When compared with euthyroid subjects, those with TSH < 0.2 mIU/L and

> 2.5 mIU/L had increased and decreased estimated glomerular

filtration rate (e-GFR), respectively. TSH levels were an independent

predictor of e-GFR.

Conclusions

A mutual relationship was observed between kidney and thyroid status.

Keywords: Creatinine; Estimated glomerular filtration rate; Kidney;

Thyroid; Thyroid stimulating hormone

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Plasma urate level is directly regulated by a voltage-driven urate efflux transporter uratv1 (slc2a9) in humans Naohiko Anzai, Kimiyoshi Ichida, Promsuk Jutabha, Toru Kimura, Ellappan Babu, Chun Ji Jin, Sunena Srivastava, Kenichiro Kitamura, Ichiro Hisatome, Hitoshi Endou, and Hiroyuki Sakurai

Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181-8611

J. Biol. Chem, 10.1074/jbc.C800156200

[[...The in vivo role of GLUT9 is supported by the fact that a renal hypouricemia patient without any mutations in SLC22A12 was found to have a missense mutation in SLC2A9, which reduced urate transport activity in vitro. Based on these data, we propose a novel model of transcellular urate transport in the kidneys: urate is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter). ...]]

http://www.jbc.org/cgi/content/abstract/C800156200v1?papetoc

>> Relationship between thyroid status and renal function in a general population of unselected outpatients >

[Guest guest]

Hi P,

Nature Genetics 40, 430 - 436 (2008) Published online: 9 March 2008 | doi:10.1038/ng.107

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

I think we got an answer but needs more work!

Bob

>> Relationship between thyroid status and renal function in a general > population of unselected outpatients > > Giuseppe Lippi(a), a Montagnana(a), Giovanni Targher(, Gian > Luca Salvagno(a) and Gian Cesare Guidi(a)> > (a)Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-> Biomediche, Università di Verona, Italy, (b)Sezione di Endocrinologia > e Malattie del Metabolismo, Dipartimento di Scienze Biomediche e > Chirurgiche, Università di Verona, Italy > > Received 18 September 2007; > revised 20 November 2007; > accepted 17 January 2008. > Available online 5 February 2008.> > Abstract> > Objective> To investigate the relationship between thyroid and kidney function.> > Design and methods> 13,383 results of serum creatinine and thyroid stimulating hormone > (TSH) were retrieved from the database of our Laboratory.> > Results> When compared with euthyroid subjects, those with TSH < 0.2 mIU/L and > > 2.5 mIU/L had increased and decreased estimated glomerular > filtration rate (e-GFR), respectively. TSH levels were an independent > predictor of e-GFR.> > Conclusions> A mutual relationship was observed between kidney and thyroid status.> > Keywords: Creatinine; Estimated glomerular filtration rate; Kidney; > Thyroid; Thyroid stimulating hormone>