Abraham, 2007, ATP Cofactors: The Key To Managing Fibromyalgia and Thyroid Health

[Guest guest]

A new article by Guy Abraham. Zoe

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"The turnover of ATP is extremely high. For example, a human at rest consumes one half of his/her weight of ATP daily. The synthesis of ATP from ADP plus a high-energy phosphate group is called oxidative phosphorilation and is dependent on the electron flow through the electron transport chain via electron carriers. Two of the B vitamins are directly involved in ATP synthesis: riboflavin and niacin. NADH and FADH2 are the major electron carriers in the synthesis of ATP. The B vitamins, niacin and riboflavin, are the precursors of the cofactors NADH and FADH2. These cofactors play an important role also in the oxidation and organification of iodide by generating hydrogen peroxide via the NADPH oxydase system.24

In some conditions, the body cannot efficiently synthesize NADH and FADH2 from niacin and riboflavin because of defect/damage to the enzymes involved in this conversion.25-28 More riboflavin and niacin are needed to override the inefficient enzymes in order to obtain adequate levels of Cofactors. Preliminary results suggest that high dosage of vitamins B2 and B3 (ATP Cofactors) combined with 100 mg of elemental iodine in the form of Lugol tablets resulted in a significant improvement of overall wellbeing in FM subjects above the response observed with iodine alone.24,29

We have tested increasing amount of riboflavin and niacin in FM patients. Niacinamide and inositol hexanicotinate were used as non-flushing derivatives of niacin. Beneficial effects were not observed until the daily intake reached 200 mg riboflavin and 1,000 mg niacin. Symptomatic improvement of patients with autoimmune thyroiditis was reported by Brownstein following orthoiodosupplementation with the ATP Cofactors.30 Decreased TPO antibody titers were observed in all the FM patients with elevated titers29 and also in patients with autoimmune thyroiditis30 following the combination of orthoiodosupplementation with ATP Cofactors."