TSH test

[Guest guest]

You wrote:

>

> It may be worth emailing Abbott Diagnostics and just asking them if

> they invented the TSH test

>

> I believe it came in with the introduction of T4.

>

Sorry, this is not possible. Synthroid was developed in the late 1930s

and distributed commercially by Flint Laboratories in the late 1950s

(Later owned by Boots, then Knoll, BASF AG, and finally Abbott). It

escaped FDA scrutiny by being accepted prior to 1938, a case of

grandfathering. It was never patented.

Radioimmuno assays for TSH were not developed until the late 1970s, the

original patent for the 1st generation test being held by Bio-Rad

Laboratories of Richmond, CA:

http://www.google.com/patents?id=c3Y4AAAAEBAJ & dq=tsh+assay+invention .

A complicating factor in describing the history of the TSH test, is that

it isn't just one test, or even four tests. It is a whole family of

tests that are now in their fourth generation (or range of precision).

When your doctor orders a TSH today, it is most likely one of several

3rd generation (TSH-3) chimeric (double) antibody test. Multiple

suppliers have test kits that reach the level of precision known as 3rd

generation.

Chuck

[Guest guest]

Hi Chuck

I am collecting information regarding TSH testing to write a paper in the hope we can prove the British Thyroid Association are incorrect when they recommend that ONLY blood tests are required to reach a diagnosis of hypothyroidism. All medical practitioners in the UK look to the BTA as the god of everything thyroid - and they are therefore not giving their patients a clinical examination, asking about their family history, looking at their signs and symptoms and backing these up with a blood test. If a patients TFT's are inside the TSH reference range, then doctors will tell them "you do not have a thyroid problem" and send them away without examining their problem further. I want to be absolutely certain that I have all my ducks properly lined up in a row stop the inevitable critics rubbishing what is said. I was told by a doctor who has found himself in the middle of the controversy concerning TSH that the TSH test was arrived at through a consensus of endocrinologists and that no proper studies were ever done, so I am trying to look at the invention of the TSH from this angle.

I am not an academic, heaven help me, so I find researching very difficult - so I do need to pick the brains of those more capable than me wherever I can find them. The leaders of the BTA need to know that there are other angles to this story and they should take these into account, but it is like banging your head on the proverbial brick wall.

Thanks for this information, I looked at the website you posted, but unfortunately, it is beyond my udnerstanding right now, but I am trying tdesperately to understand what all this means.

Sheila

Sorry, this is not possible. Synthroid was developed in the late 1930s and distributed commercially by Flint Laboratories in the late 1950s (Later owned by Boots, then Knoll, BASF AG, and finally Abbott). It escaped FDA scrutiny by being accepted prior to 1938, a case of grandfathering. It was never patented.Radioimmuno assays for TSH were not developed until the late 1970s, the original patent for the 1st generation test being held by Bio-Rad Laboratories of Richmond, CA:http://www.google.com/patents?id=c3Y4AAAAEBAJ & dq=tsh+assay+invention .A complicating factor in describing the history of the TSH test, is that it isn't just one test, or even four tests. It is a whole family of tests that are now in their fourth generation (or range of precision). When your doctor orders a TSH today, it is most likely one of several 3rd generation (TSH-3) chimeric (double) antibody test. Multiple suppliers have test kits that reach the level of precision known as 3rd generation.ChuckNo virus found in this incoming message.

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[Guest guest]

Could you send me this article as well A.

Lilian